FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1838116882> ?p ?o ?g. }

• W1838116882 endingPage "157" @default.
• W1838116882 startingPage "145" @default.
• W1838116882 abstract "Recent studies have demonstrated that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, mediates mitochondria-dependent apoptosis through mitochondrial division. However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity. In this study, we determined that CPF-induced mitochondrial apoptosis is mediated by Drp1 translocation in SH-SY5Y human neuroblastoma cells. Our results showed that CPF treatment induced intrinsic apoptosis by activating caspase-9, caspase-3, and cytochrome c release in SH-SY5Y cells. Cytosolic Drp1 translocated to the mitochondria in CPF-treated cells and was phosphorylated at Ser616. Treating cells with CPF induced the generation of reactive oxygen species (ROS) and activation of mitogen-activated protein kinases (MAPKs). Inhibiting this ROS generation and MAPK activation abolished CPF-induced expression of phospho-Drp1. Furthermore, Drp1 was required for p53 to translocate to the mitochondria under CPF-induced oxidative stress. Treating cells with mitochondrial-division inhibitor-1 (mdivi-1), which blocks Drp1 translocation, increased the viability of CPF-treated cells by abrogating Drp1 translocation and caspase-3 activation. Specifically, pretreating cells with mdivi-1 inhibited Bax translocation to the mitochondria by blocking p53 signaling. Taken together, these data reveal a novel mechanism by which Drp1 activates mitochondrial-dependent apoptosis and indicate that inhibiting Dpr1 function can protect against CPF-induced cytotoxicity. We propose that inhibiting Drp1 is a possible therapeutic approach for pesticide-induced toxicity when hyperactivated Drp1 contributes to pathology." @default.
• W1838116882 created "2016-06-24" @default.
• W1838116882 creator A5027724820 @default.
• W1838116882 creator A5046059487 @default.
• W1838116882 creator A5049675779 @default.
• W1838116882 creator A5088645808 @default.
• W1838116882 date "2015-12-01" @default.
• W1838116882 modified "2023-10-01" @default.
• W1838116882 title "Dynamin-related protein 1 mediates mitochondria-dependent apoptosis in chlorpyrifos-treated SH-SY5Y cells" @default.
• W1838116882 cites W1884222370 @default.
• W1838116882 cites W1948394557 @default.
• W1838116882 cites W1963810388 @default.
• W1838116882 cites W1967996072 @default.
• W1838116882 cites W1969548568 @default.
• W1838116882 cites W1970313490 @default.
• W1838116882 cites W1970560403 @default.
• W1838116882 cites W1972332133 @default.
• W1838116882 cites W1973966118 @default.
• W1838116882 cites W1987258027 @default.
• W1838116882 cites W1997057746 @default.
• W1838116882 cites W2002753297 @default.
• W1838116882 cites W2004391012 @default.
• W1838116882 cites W2009395778 @default.
• W1838116882 cites W2010369463 @default.
• W1838116882 cites W2014873374 @default.
• W1838116882 cites W2017009693 @default.
• W1838116882 cites W2033893811 @default.
• W1838116882 cites W2035672592 @default.
• W1838116882 cites W2038552318 @default.
• W1838116882 cites W2039426833 @default.
• W1838116882 cites W2041967565 @default.
• W1838116882 cites W2044079387 @default.
• W1838116882 cites W2056098585 @default.
• W1838116882 cites W2059009119 @default.
• W1838116882 cites W2060810889 @default.
• W1838116882 cites W2065008438 @default.
• W1838116882 cites W2073889665 @default.
• W1838116882 cites W2074905627 @default.
• W1838116882 cites W2075996457 @default.
• W1838116882 cites W2079079491 @default.
• W1838116882 cites W2085335902 @default.
• W1838116882 cites W2085367705 @default.
• W1838116882 cites W2087128708 @default.
• W1838116882 cites W2087976242 @default.
• W1838116882 cites W2089855915 @default.
• W1838116882 cites W2092514612 @default.
• W1838116882 cites W2098548022 @default.
• W1838116882 cites W2111370276 @default.
• W1838116882 cites W2112872187 @default.
• W1838116882 cites W2113664096 @default.
• W1838116882 cites W2117313899 @default.
• W1838116882 cites W2118016441 @default.
• W1838116882 cites W2128347259 @default.
• W1838116882 cites W2134864772 @default.
• W1838116882 cites W2140872647 @default.
• W1838116882 cites W2143410022 @default.
• W1838116882 cites W2144463858 @default.
• W1838116882 cites W2147550463 @default.
• W1838116882 cites W2147551208 @default.
• W1838116882 cites W2150677449 @default.
• W1838116882 cites W2157334943 @default.
• W1838116882 cites W2157510237 @default.
• W1838116882 cites W2162789670 @default.
• W1838116882 cites W2167553705 @default.
• W1838116882 cites W2168208715 @default.
• W1838116882 cites W2320101893 @default.
• W1838116882 cites W2331055068 @default.
• W1838116882 cites W2418781034 @default.
• W1838116882 doi "https://doi.org/10.1016/j.neuro.2015.10.008" @default.
• W1838116882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26598294" @default.
• W1838116882 hasPublicationYear "2015" @default.
• W1838116882 type Work @default.
• W1838116882 sameAs 1838116882 @default.
• W1838116882 citedByCount "27" @default.
• W1838116882 countsByYear W18381168822016 @default.
• W1838116882 countsByYear W18381168822017 @default.
• W1838116882 countsByYear W18381168822018 @default.
• W1838116882 countsByYear W18381168822019 @default.
• W1838116882 countsByYear W18381168822020 @default.
• W1838116882 countsByYear W18381168822021 @default.
• W1838116882 countsByYear W18381168822022 @default.
• W1838116882 countsByYear W18381168822023 @default.
• W1838116882 crossrefType "journal-article" @default.
• W1838116882 hasAuthorship W1838116882A5027724820 @default.
• W1838116882 hasAuthorship W1838116882A5046059487 @default.
• W1838116882 hasAuthorship W1838116882A5049675779 @default.
• W1838116882 hasAuthorship W1838116882A5088645808 @default.
• W1838116882 hasConcept C173358068 @default.
• W1838116882 hasConcept C17619807 @default.
• W1838116882 hasConcept C185592680 @default.
• W1838116882 hasConcept C190283241 @default.
• W1838116882 hasConcept C2775998712 @default.
• W1838116882 hasConcept C2776715637 @default.
• W1838116882 hasConcept C2777324860 @default.
• W1838116882 hasConcept C2779083432 @default.
• W1838116882 hasConcept C28859421 @default.
• W1838116882 hasConcept C29311851 @default.
• W1838116882 hasConcept C31573885 @default.

• next