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• W1838152396 startingPage "1789" @default.
• W1838152396 abstract "The neuron-specific phosphoprotein B-50 (Mr 48 kDa, isoelectric point, IEP, 4.5), which is identical to GAP43, is a member of a family of growth-associated proteins. Protein B-50 is a major phosphoprotein in nerve growth cones isolated from fetal rat brain. In a growth cone particulate fraction (GCp), endogenous B-50 phosphorylation is Ca2+- dependent and is unaffected by cAMP. Addition of purified protein kinase C (PKC) to GCP enhances B-50 phosphorylation. In heat- inactivated GCp, B-50 is one of the major substrates of purified PKC. Endogenous B-50 phosphorylation in GCP is stimulated in a dose- dependent manner by 4 beta-phorbol diesters, known to activate PKC, but not by the inactive 4 alpha-phorbol derivatives. In synaptic plasma membranes (SPM) isolated from adult rat brain, the degree of B-50 phosphorylation has been implicated in the modulation of receptor- mediated polyphosphoinositide (PPI) hydrolysis. In addition to B-50 and its kinase, PKC, the GCp fraction was also shown to contain all other components of such a modulatory system: the phosphatidylinositol 4- phosphate (PIP)-kinase, as shown on Western blots with affinity- purified IgGs against PIP-kinase, and the polyphosphoinosides, PIP and phosphatidylinositol 4,5-bisphosphate (PIP2), since the addition of gamma-32P-ATP to the GCp fraction not only results in B-50 phosphorylation but also in the labeling of phosphatidic acid (PA), PIP, and PIP2. ACTH1–24, which inhibits B-50 phosphorylation in the GCp fraction in a dose-dependent manner (IC50 = 5 x 10(-6) M), stimulates PIP2 labeling dose-dependently in the same preparation.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W1838152396 created "2016-06-24" @default.
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• W1838152396 date "1988-05-01" @default.
• W1838152396 modified "2023-10-16" @default.
• W1838152396 title "B-50 phosphorylation and polyphosphoinositide metabolism in nerve growth cone membranes" @default.
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• W1838152396 doi "https://doi.org/10.1523/jneurosci.08-05-01789.1988" @default.
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