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- W1838332596 abstract "Down syndrome (DS) is caused by trisomy of chromosome 21, and affects 1/700 live births. DS results in about 80 clinical phenotypes, including cognitive impairment. DYRK1A , a chromosome 21 gene, has been linked to alterations in morphology and function of the brain resulting in cognitive impairment. Epigallocatechin-3-gallate (EGCG), an inhibitor of DYRK1A protein activity, has been proposed as a possible treatment for the increased activity of this gene in trisomic individuals. Using the Ts65Dn DS mouse model, we examined the effects of EGCG treatment on hippocampal dependent learning and memory using a novel object recognition task (NOR). The mice were given ~10-30 mg/kg/day EGCG or water (control) starting at 3 weeks of age. A subset of the mice were treated for 3 weeks with EGCG and tested while the other group was given ECGC for 7 weeks of age all the way through testing. The mice were handled two days before testing and then underwent a series of behavioral tasks. The NOR consisted of a box with the objects placed diagonally from each other. The mice underwent 3 days of testing with 15 minute sessions per day consisting of habituation, exposure, and test day, all of which were recorded and analyzed to determine time spent exploring novel object in relation to familiar. The exposure and test day videos were hand timed by 3 scorers that were unaware of each mouse’s genotype at the time of scoring to eliminate bias. Our current results suggest that there is a gentotype effect but no treatment effect, most likely due to the variability between each individual scorer. We hypothesize that a high continuous dose EGCG may be needed in order to see cognitive deficit reduction. Mentor: Randall J. Roper, Department of Biology, Purdue University School of Science, Indiana University-Purdue University Indianapolis; Indianapolis, IN" @default.
- W1838332596 created "2016-06-24" @default.
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- W1838332596 date "2014-11-10" @default.
- W1838332596 modified "2023-09-27" @default.
- W1838332596 title "Effects of EGCG Treatment on Cognitive Impairment in Ts65Dn Down Syndrome Mice" @default.
- W1838332596 hasPublicationYear "2014" @default.
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