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• W1838643145 abstract "Background— Intravenous thrombolysis (IVT) for acute ischemic stroke is subject to label and guideline contraindications. Updated European guidelines in 2008/2009 recommended IVT in selected patients aged >80 years and stroke onset-to-treatment time 3 to 4.5 hours, which the label still prohibited. Our aim was to compare contraindication nonadherence before and after the guideline update. Methods and Results— Data on IVT-treated patients with stroke at 232 European hospitals participating in the Safe Implementation of Treatments in Stroke registry during both periods 2006 to 2007 (n=6354) and 2010 to 2011 (n=12 046). After the 2008/2009 guideline update, the proportion of patients nonadherent to label increased from 23.6% to 51.1% ( P <0.001). Specifically, nonadherence to onset-to-treatment time >3 hours increased from 8.2% to 27.9% and IVT in patients aged >80 years from 8.9% to 17.2% (both P <0.001). Nonadherence also increased to the contraindications severe stroke (National Institutes of Health Stroke Scale score >25), onset-to-treatment time >4.5 hours, blood pressure >185/110 mm Hg, and ongoing oral anticoagulation (all P ≤0.001). Higher hospital IVT patient volumes were associated with higher nonadherence rates. Conclusions— After the European guideline update, new recommendations were promptly adopted and nonadherence to the unchanged label increased. Label contraindications should be updated." @default.
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• W1838643145 date "2015-10-01" @default.
• W1838643145 modified "2023-10-06" @default.
• W1838643145 title "Changes in European Label and Guideline Adherence After Updated Recommendations for Stroke Thrombolysis" @default.
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• W1838643145 doi "https://doi.org/10.1161/circoutcomes.115.002097" @default.
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