Matches in SemOpenAlex for { <https://semopenalex.org/work/W1838703570> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1838703570 endingPage "8" @default.
- W1838703570 startingPage "5624" @default.
- W1838703570 abstract "This study shows for the first time that 1,25-dihydroxyvitamin D3[1,25-(OH)2D3] and two fluorinated analogues of 1,25-(OH)2D3 [24,24-F2-1,25-(OH)2D3 and 26, 26, 26, 27, 27, 27-F6-1,25-(OH)2D3] induce macrophage differentiation of human normal and leukemic myeloid stem cells. The addition of either 1,25-(OH)2D3 or one of the two fluorinated analogues of 1,25-(OH)2D3 at concentrations as low as 10(-9) M to culture plates containing normal human marrow cells stimulated myeloid stem cells to preferentially differentiate to colonies of monocytes and macrophages. Over 80% of the normal human myeloid colonies were composed of only monocytes and macrophages in culture plates containing 10(-7) M 1,25-(OH)2D3 or one of the fluorinated analogues. In contrast, control plates not containing 1,25-(OH)2D3 had less than 35% macrophage colonies. Likewise, 1,25-(OH)2D3 and the two vitamin D analogues induced macrophage differentiation of leukemic colony-forming cells taken from patients. In plates containing 10(-7) M 1,25-(OH)2D3 or one of the analogues at 10(-8) M, 80% of chronic myelogenous leukemia and approximately 50% of acute nonlymphocytic leukemia colony-forming cells differentiated to macrophage-like cells. In contrast, control plates had about 30 and 20% macrophage colonies in cultures from chronic myelogenous leukemia and acute nonlymphocytic leukemia patients, respectively. Our findings suggest that 1,25-(OH)2D3 may play a role in hematopoiesis and that the compound or a related analogue may possibly have a therapeutic role in some leukemias." @default.
- W1838703570 created "2016-06-24" @default.
- W1838703570 creator A5000867478 @default.
- W1838703570 creator A5030128972 @default.
- W1838703570 creator A5030466764 @default.
- W1838703570 creator A5055804570 @default.
- W1838703570 creator A5082903377 @default.
- W1838703570 date "1984-12-01" @default.
- W1838703570 modified "2023-09-23" @default.
- W1838703570 title "Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues." @default.
- W1838703570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6594194" @default.
- W1838703570 hasPublicationYear "1984" @default.
- W1838703570 type Work @default.
- W1838703570 sameAs 1838703570 @default.
- W1838703570 citedByCount "84" @default.
- W1838703570 countsByYear W18387035702013 @default.
- W1838703570 countsByYear W18387035702014 @default.
- W1838703570 countsByYear W18387035702016 @default.
- W1838703570 countsByYear W18387035702018 @default.
- W1838703570 countsByYear W18387035702020 @default.
- W1838703570 countsByYear W18387035702022 @default.
- W1838703570 crossrefType "journal-article" @default.
- W1838703570 hasAuthorship W1838703570A5000867478 @default.
- W1838703570 hasAuthorship W1838703570A5030128972 @default.
- W1838703570 hasAuthorship W1838703570A5030466764 @default.
- W1838703570 hasAuthorship W1838703570A5055804570 @default.
- W1838703570 hasAuthorship W1838703570A5082903377 @default.
- W1838703570 hasConcept C104317684 @default.
- W1838703570 hasConcept C109159458 @default.
- W1838703570 hasConcept C126322002 @default.
- W1838703570 hasConcept C134018914 @default.
- W1838703570 hasConcept C148738053 @default.
- W1838703570 hasConcept C153911025 @default.
- W1838703570 hasConcept C185592680 @default.
- W1838703570 hasConcept C202751555 @default.
- W1838703570 hasConcept C203014093 @default.
- W1838703570 hasConcept C2776960273 @default.
- W1838703570 hasConcept C2778461978 @default.
- W1838703570 hasConcept C2778729363 @default.
- W1838703570 hasConcept C2779244956 @default.
- W1838703570 hasConcept C2779282312 @default.
- W1838703570 hasConcept C28328180 @default.
- W1838703570 hasConcept C502942594 @default.
- W1838703570 hasConcept C55493867 @default.
- W1838703570 hasConcept C71924100 @default.
- W1838703570 hasConcept C86803240 @default.
- W1838703570 hasConcept C95444343 @default.
- W1838703570 hasConceptScore W1838703570C104317684 @default.
- W1838703570 hasConceptScore W1838703570C109159458 @default.
- W1838703570 hasConceptScore W1838703570C126322002 @default.
- W1838703570 hasConceptScore W1838703570C134018914 @default.
- W1838703570 hasConceptScore W1838703570C148738053 @default.
- W1838703570 hasConceptScore W1838703570C153911025 @default.
- W1838703570 hasConceptScore W1838703570C185592680 @default.
- W1838703570 hasConceptScore W1838703570C202751555 @default.
- W1838703570 hasConceptScore W1838703570C203014093 @default.
- W1838703570 hasConceptScore W1838703570C2776960273 @default.
- W1838703570 hasConceptScore W1838703570C2778461978 @default.
- W1838703570 hasConceptScore W1838703570C2778729363 @default.
- W1838703570 hasConceptScore W1838703570C2779244956 @default.
- W1838703570 hasConceptScore W1838703570C2779282312 @default.
- W1838703570 hasConceptScore W1838703570C28328180 @default.
- W1838703570 hasConceptScore W1838703570C502942594 @default.
- W1838703570 hasConceptScore W1838703570C55493867 @default.
- W1838703570 hasConceptScore W1838703570C71924100 @default.
- W1838703570 hasConceptScore W1838703570C86803240 @default.
- W1838703570 hasConceptScore W1838703570C95444343 @default.
- W1838703570 hasIssue "12 Pt 1" @default.
- W1838703570 hasLocation W18387035701 @default.
- W1838703570 hasOpenAccess W1838703570 @default.
- W1838703570 hasPrimaryLocation W18387035701 @default.
- W1838703570 hasRelatedWork W2037983654 @default.
- W1838703570 hasRelatedWork W2063982457 @default.
- W1838703570 hasRelatedWork W2075542228 @default.
- W1838703570 hasRelatedWork W2081055363 @default.
- W1838703570 hasRelatedWork W2144481778 @default.
- W1838703570 hasRelatedWork W2623762817 @default.
- W1838703570 hasRelatedWork W2899610424 @default.
- W1838703570 hasRelatedWork W4207022676 @default.
- W1838703570 hasRelatedWork W4210379329 @default.
- W1838703570 hasRelatedWork W4224040773 @default.
- W1838703570 hasVolume "44" @default.
- W1838703570 isParatext "false" @default.
- W1838703570 isRetracted "false" @default.
- W1838703570 magId "1838703570" @default.
- W1838703570 workType "article" @default.