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• W1838714565 abstract "The biologically active form of vitamin D3, calcitriol (1,25-(OH)2 D3), plays a key role in mineral homeostasis and bone formation and dietary vitamin D3 deficiency is a major cause of bone disorders in poultry. Supplementary dietary cholecalciferol (25-hydroxyvitamin D, 25-OH), the precursor of calcitriol, is commonly employed to combat this problem; however, dosage must be carefully determined as excess dietary vitamin D can cause toxicity resulting in a decrease in bone calcification, hypercalcinemia and renal failure. Despite much research on the therapeutic administration of dietary vitamin D in humans, the relative sensitivity of avian species to exogenous vitamin D has not been well defined. In order to determine the effects of exogenous 1,25-(OH)2 D3 during avian osteogenesis, chicken bone marrow-derived mesenchymal stem cells (BM-MSCs) were exposed to varying doses of 1,25-(OH)2 D3 during in vitro osteogenic differentiation and examined for markers of early proliferation and osteogenic induction. Similar to humans and other mammals, poultry BM-MSCs were found to be highly sensitive to exogenous 1,25-(OH)2 D3 with super pharmacological levels exerting significant inhibition of mineralization and loss of cell proliferation in vitro. Strain related differences were apparent, with BM-MCSs derived from layers strains showing a higher level of sensitivity to 1,25-(OH)2 D3 than those from broilers. These data suggest that understanding species and strain specific sensitivities to 1,25-(OH)2 D3 is important for optimizing bone health in the poultry industry and that use of avian BM-MSCs are a useful tool for examining underlying effects of genetic variation in poultry." @default.
• W1838714565 created "2016-06-24" @default.
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• W1838714565 date "2015-11-01" @default.
• W1838714565 modified "2023-10-01" @default.
• W1838714565 title "Super pharmacological levels of calcitriol (1,25-(OH)2 D3) inhibits mineral deposition and decreases cell proliferation in a strain dependent manner in chicken mesenchymal stem cells undergoing osteogenic differentiation in vitro" @default.
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• W1838714565 doi "https://doi.org/10.3382/ps/pev284" @default.
• W1838714565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4988625" @default.
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