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• W1838759849 abstract "Abstract Cell‐surface receptors constitute the major route by which signals are conveyed from the extracellular to the intracellular environment of cells. This article focuses on the three major types of cell‐surface receptors: catalytic tyrosine kinase receptors, cytokine receptors, and seven‐transmembrane receptors. The structure of the extracellular portions of these receptors enables them to recognize specific signals, such as growth factors, cytokines, peptides, and hormones. Binding of these signals changes the conformation of the receptors themselves, which translates to modulation of intracellular pathways. These pathways regulate diverse cellular functions such as proliferation, survival, and apoptosis. In the case of genetic diseases, mutations have been identified in many receptors, and these mutations result in aberrant signaling. By understanding the structural and molecular reasons for the pathological phenotypes, better pharmacological agents can be generated to treat these receptor‐driven diseases." @default.
• W1838759849 created "2016-06-24" @default.
• W1838759849 creator A5008190196 @default.
• W1838759849 creator A5043390661 @default.
• W1838759849 date "2010-03-15" @default.
• W1838759849 modified "2023-10-10" @default.
• W1838759849 title "Cell‐Surface Receptors: Structure, Activation, and Signaling" @default.
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• W1838759849 doi "https://doi.org/10.1002/9780470054581.eib207" @default.
• W1838759849 hasPublicationYear "2010" @default.
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