FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1838973073> ?p ?o ?g. }

• W1838973073 endingPage "1327" @default.
• W1838973073 startingPage "1321" @default.
• W1838973073 abstract "Abstract A common assumption in comparative sequence analysis is that the sequences have evolved with the same pattern of nucleotide substitution (homogeneity of the evolutionary process). Violation of this assumption is known to adversely impact the accuracy of phylogenetic inference and tests of evolutionary hypotheses. Here we propose a disparity index, ID, which measures the observed difference in evolutionary patterns for a pair of sequences. On the basis of this index, we have developed a Monte Carlo procedure to test the homogeneity of the observed patterns. This test does not require a priori knowledge of the pattern of substitutions, extent of rate heterogeneity among sites, or the evolutionary relationship among sequences. Computer simulations show that the ID-test is more powerful than the commonly used χ2-test under a variety of biologically realistic models of sequence evolution. An application of this test in an analysis of 3789 pairs of orthologous human and mouse protein-coding genes reveals that the observed evolutionary patterns in neutral sites are not homogeneous in 41% of the genes, apparently due to shifts in G + C content. Thus, the proposed test can be used as a diagnostic tool to identify genes and lineages that have evolved with substantially different evolutionary processes as reflected in the observed patterns of change. Identification of such genes and lineages is an important early step in comparative genomics and molecular phylogenetic studies to discover evolutionary processes that have shaped organismal genomes." @default.
• W1838973073 created "2016-06-24" @default.
• W1838973073 creator A5011224797 @default.
• W1838973073 creator A5043473700 @default.
• W1838973073 date "2001-07-01" @default.
• W1838973073 modified "2023-10-16" @default.
• W1838973073 title "Disparity Index: A Simple Statistic to Measure and Test the Homogeneity of Substitution Patterns Between Molecular Sequences" @default.
• W1838973073 cites W1525734744 @default.
• W1838973073 cites W1966786019 @default.
• W1838973073 cites W1996019265 @default.
• W1838973073 cites W2006376319 @default.
• W1838973073 cites W2009596137 @default.
• W1838973073 cites W2029511764 @default.
• W1838973073 cites W2038359695 @default.
• W1838973073 cites W2043947510 @default.
• W1838973073 cites W2056005674 @default.
• W1838973073 cites W2060229130 @default.
• W1838973073 cites W2069498712 @default.
• W1838973073 cites W2099411299 @default.
• W1838973073 cites W2166060927 @default.
• W1838973073 doi "https://doi.org/10.1093/genetics/158.3.1321" @default.
• W1838973073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461708" @default.
• W1838973073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11454778" @default.
• W1838973073 hasPublicationYear "2001" @default.
• W1838973073 type Work @default.
• W1838973073 sameAs 1838973073 @default.
• W1838973073 citedByCount "161" @default.
• W1838973073 countsByYear W18389730732012 @default.
• W1838973073 countsByYear W18389730732013 @default.
• W1838973073 countsByYear W18389730732014 @default.
• W1838973073 countsByYear W18389730732015 @default.
• W1838973073 countsByYear W18389730732016 @default.
• W1838973073 countsByYear W18389730732017 @default.
• W1838973073 countsByYear W18389730732018 @default.
• W1838973073 countsByYear W18389730732019 @default.
• W1838973073 countsByYear W18389730732020 @default.
• W1838973073 countsByYear W18389730732021 @default.
• W1838973073 countsByYear W18389730732022 @default.
• W1838973073 countsByYear W18389730732023 @default.
• W1838973073 crossrefType "journal-article" @default.
• W1838973073 hasAuthorship W1838973073A5011224797 @default.
• W1838973073 hasAuthorship W1838973073A5043473700 @default.
• W1838973073 hasBestOaLocation W18389730732 @default.
• W1838973073 hasConcept C104317684 @default.
• W1838973073 hasConcept C105176652 @default.
• W1838973073 hasConcept C105795698 @default.
• W1838973073 hasConcept C141231307 @default.
• W1838973073 hasConcept C142259097 @default.
• W1838973073 hasConcept C154945302 @default.
• W1838973073 hasConcept C1570309 @default.
• W1838973073 hasConcept C166393388 @default.
• W1838973073 hasConcept C167683757 @default.
• W1838973073 hasConcept C189206191 @default.
• W1838973073 hasConcept C193252679 @default.
• W1838973073 hasConcept C2776214188 @default.
• W1838973073 hasConcept C33923547 @default.
• W1838973073 hasConcept C41008148 @default.
• W1838973073 hasConcept C54355233 @default.
• W1838973073 hasConcept C70721500 @default.
• W1838973073 hasConcept C78458016 @default.
• W1838973073 hasConcept C86803240 @default.
• W1838973073 hasConcept C89128539 @default.
• W1838973073 hasConcept C90132467 @default.
• W1838973073 hasConceptScore W1838973073C104317684 @default.
• W1838973073 hasConceptScore W1838973073C105176652 @default.
• W1838973073 hasConceptScore W1838973073C105795698 @default.
• W1838973073 hasConceptScore W1838973073C141231307 @default.
• W1838973073 hasConceptScore W1838973073C142259097 @default.
• W1838973073 hasConceptScore W1838973073C154945302 @default.
• W1838973073 hasConceptScore W1838973073C1570309 @default.
• W1838973073 hasConceptScore W1838973073C166393388 @default.
• W1838973073 hasConceptScore W1838973073C167683757 @default.
• W1838973073 hasConceptScore W1838973073C189206191 @default.
• W1838973073 hasConceptScore W1838973073C193252679 @default.
• W1838973073 hasConceptScore W1838973073C2776214188 @default.
• W1838973073 hasConceptScore W1838973073C33923547 @default.
• W1838973073 hasConceptScore W1838973073C41008148 @default.
• W1838973073 hasConceptScore W1838973073C54355233 @default.
• W1838973073 hasConceptScore W1838973073C70721500 @default.
• W1838973073 hasConceptScore W1838973073C78458016 @default.
• W1838973073 hasConceptScore W1838973073C86803240 @default.
• W1838973073 hasConceptScore W1838973073C89128539 @default.
• W1838973073 hasConceptScore W1838973073C90132467 @default.
• W1838973073 hasIssue "3" @default.
• W1838973073 hasLocation W18389730731 @default.
• W1838973073 hasLocation W18389730732 @default.
• W1838973073 hasOpenAccess W1838973073 @default.
• W1838973073 hasPrimaryLocation W18389730731 @default.
• W1838973073 hasRelatedWork W2074297028 @default.
• W1838973073 hasRelatedWork W2084020295 @default.
• W1838973073 hasRelatedWork W2091770942 @default.
• W1838973073 hasRelatedWork W2130436157 @default.
• W1838973073 hasRelatedWork W2167774246 @default.
• W1838973073 hasRelatedWork W2521866209 @default.
• W1838973073 hasRelatedWork W2608097890 @default.
• W1838973073 hasRelatedWork W3023271652 @default.
• W1838973073 hasRelatedWork W3166248435 @default.
• W1838973073 hasRelatedWork W4365142018 @default.

• next