FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1838989517> ?p ?o ?g. }

• W1838989517 endingPage "13" @default.
• W1838989517 startingPage "13" @default.
• W1838989517 abstract "A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides. RNase H-active, chimeric methylphosphonodiester / phosphodiester antisense oligodeoxynucleotides targeting bases 1147–1166 of c-myc mRNA downregulated c-Myc protein and induced apoptosis and cell cycle arrest respectively in cultures of MOLT-4 and KYO1 human leukemia cells. In contrast, an RNase H-inactive, morpholino antisense oligonucleotide analogue 28-mer, simultaneously targeting the exon 2 splice acceptor site and initiation codon, reduced c-Myc protein to barely detectable levels but did not affect cell proliferation in these or other leukemia lines. The RNase H-active oligodeoxynucleotide 20-mers contained the phosphodiester linked motif CGTTG, which as an apoptosis inducing CpG oligodeoxynucleotide 5-mer of sequence type CGNNN (N = A, G, C, or T) had potent activity against MOLT-4 cells. The 5-mer mimicked the antiproliferative effects of the 20-mer in the absence of any antisense activity against c-myc mRNA, while the latter still reduced expression of c-myc in a subline of MOLT-4 cells that had been selected for resistance to CGTTA, but in this case the oligodeoxynucleotide failed to induce apoptosis or cell cycle arrest. We conclude that the biological activity of the chimeric c-myc antisense 20-mers resulted from a non-antisense mechanism related to the CGTTG motif contained within the sequence, and not through downregulation of c-myc. Although the oncogene may have been implicated in the etiology of the original leukemias, expression of c-myc is apparently no longer required to sustain continuous cell proliferation in these culture lines." @default.
• W1838989517 created "2016-06-24" @default.
• W1838989517 creator A5011733008 @default.
• W1838989517 creator A5020913751 @default.
• W1838989517 creator A5025297677 @default.
• W1838989517 creator A5037134461 @default.
• W1838989517 date "2001-01-01" @default.
• W1838989517 modified "2023-09-30" @default.
• W1838989517 cites W1480318984 @default.
• W1838989517 cites W1496573856 @default.
• W1838989517 cites W16491628 @default.
• W1838989517 cites W183337522 @default.
• W1838989517 cites W1953035097 @default.
• W1838989517 cites W1967028954 @default.
• W1838989517 cites W1969818257 @default.
• W1838989517 cites W2013172326 @default.
• W1838989517 cites W2033461855 @default.
• W1838989517 cites W2048324748 @default.
• W1838989517 cites W2056627100 @default.
• W1838989517 cites W2060546037 @default.
• W1838989517 cites W2103647561 @default.
• W1838989517 cites W2104373533 @default.
• W1838989517 cites W2113557330 @default.
• W1838989517 cites W2155463132 @default.
• W1838989517 cites W2156872475 @default.
• W1838989517 cites W2165756095 @default.
• W1838989517 cites W2170507464 @default.
• W1838989517 cites W2326831456 @default.
• W1838989517 cites W2326923413 @default.
• W1838989517 cites W2333643117 @default.
• W1838989517 cites W2339646853 @default.
• W1838989517 cites W2411749932 @default.
• W1838989517 cites W2413736157 @default.
• W1838989517 doi "https://doi.org/10.1186/1471-2199-2-13" @default.
• W1838989517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/60647" @default.
• W1838989517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11734062" @default.
• W1838989517 hasPublicationYear "2001" @default.
• W1838989517 type Work @default.
• W1838989517 sameAs 1838989517 @default.
• W1838989517 citedByCount "6" @default.
• W1838989517 countsByYear W18389895172017 @default.
• W1838989517 crossrefType "journal-article" @default.
• W1838989517 hasAuthorship W1838989517A5011733008 @default.
• W1838989517 hasAuthorship W1838989517A5020913751 @default.
• W1838989517 hasAuthorship W1838989517A5025297677 @default.
• W1838989517 hasAuthorship W1838989517A5037134461 @default.
• W1838989517 hasBestOaLocation W18389895171 @default.
• W1838989517 hasConcept C104317684 @default.
• W1838989517 hasConcept C10879258 @default.
• W1838989517 hasConcept C129312508 @default.
• W1838989517 hasConcept C136571751 @default.
• W1838989517 hasConcept C153911025 @default.
• W1838989517 hasConcept C173396325 @default.
• W1838989517 hasConcept C190283241 @default.
• W1838989517 hasConcept C29537977 @default.
• W1838989517 hasConcept C38441620 @default.
• W1838989517 hasConcept C54009773 @default.
• W1838989517 hasConcept C54355233 @default.
• W1838989517 hasConcept C552990157 @default.
• W1838989517 hasConcept C55493867 @default.
• W1838989517 hasConcept C67705224 @default.
• W1838989517 hasConcept C69766542 @default.
• W1838989517 hasConcept C81885089 @default.
• W1838989517 hasConcept C86803240 @default.
• W1838989517 hasConceptScore W1838989517C104317684 @default.
• W1838989517 hasConceptScore W1838989517C10879258 @default.
• W1838989517 hasConceptScore W1838989517C129312508 @default.
• W1838989517 hasConceptScore W1838989517C136571751 @default.
• W1838989517 hasConceptScore W1838989517C153911025 @default.
• W1838989517 hasConceptScore W1838989517C173396325 @default.
• W1838989517 hasConceptScore W1838989517C190283241 @default.
• W1838989517 hasConceptScore W1838989517C29537977 @default.
• W1838989517 hasConceptScore W1838989517C38441620 @default.
• W1838989517 hasConceptScore W1838989517C54009773 @default.
• W1838989517 hasConceptScore W1838989517C54355233 @default.
• W1838989517 hasConceptScore W1838989517C552990157 @default.
• W1838989517 hasConceptScore W1838989517C55493867 @default.
• W1838989517 hasConceptScore W1838989517C67705224 @default.
• W1838989517 hasConceptScore W1838989517C69766542 @default.
• W1838989517 hasConceptScore W1838989517C81885089 @default.
• W1838989517 hasConceptScore W1838989517C86803240 @default.
• W1838989517 hasIssue "1" @default.
• W1838989517 hasLocation W18389895171 @default.
• W1838989517 hasLocation W18389895172 @default.
• W1838989517 hasLocation W18389895173 @default.
• W1838989517 hasLocation W18389895174 @default.
• W1838989517 hasOpenAccess W1838989517 @default.
• W1838989517 hasPrimaryLocation W18389895171 @default.
• W1838989517 hasRelatedWork W2016147415 @default.
• W1838989517 hasRelatedWork W2032573377 @default.
• W1838989517 hasRelatedWork W2043026175 @default.
• W1838989517 hasRelatedWork W2054281456 @default.
• W1838989517 hasRelatedWork W2069307743 @default.
• W1838989517 hasRelatedWork W2135511750 @default.
• W1838989517 hasRelatedWork W2157888763 @default.
• W1838989517 hasRelatedWork W2162332760 @default.
• W1838989517 hasRelatedWork W2413736157 @default.
• W1838989517 hasRelatedWork W2951015646 @default.

• next