Matches in SemOpenAlex for { <https://semopenalex.org/work/W1839259001> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1839259001 endingPage "1679" @default.
- W1839259001 startingPage "1673" @default.
- W1839259001 abstract "Bendamustine hydrochloride is an alkylating antitumor agent with a good efficacy in the treatment of chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin's lymphoma (B-NHL). Under the stressed conditions, two degradant impurities in bendamustine hydrochloride drug product were detected by high-performance liquid chromatography. These two degradant impurities were isolated from preparative liquid chromatography, and were further characterized using Q-TOF/MS and nuclear magnetic resonance (NMR). Based on the MS and NMR spectral data, they were characterized as 4-[5-(2-chloro-ethylamino)-1-methyl-1H-benzoimidazol-2-yl] butyric acid hydrochloride (impurity-A) and 4-{5-[[2-(4-{5-[bis-(2-chloroethyl) amino]-1-methyl-1H-benzoimidazol-2-yl}-butyryloxy)-ethyl]-(2-chloroethyl)amino]-1-methyl-3a, 7a-dihydro-1H-benzoimidazol-2-yl} butyric acid hydrochloride (impurity-B). Isolation, structural elucidation of these two impurities by spectral data (Q-TOF/MS, (1)H NMR, (13)C NMR, D2O exchange NMR and two-dimensional NMR) and the probable formation mechanism of the impurities were discussed." @default.
- W1839259001 created "2016-06-24" @default.
- W1839259001 creator A5001633872 @default.
- W1839259001 creator A5002649486 @default.
- W1839259001 creator A5042346357 @default.
- W1839259001 creator A5058014567 @default.
- W1839259001 creator A5058533540 @default.
- W1839259001 creator A5072778953 @default.
- W1839259001 creator A5074592492 @default.
- W1839259001 creator A5080915473 @default.
- W1839259001 date "2015-06-07" @default.
- W1839259001 modified "2023-09-24" @default.
- W1839259001 title "Determination and Characterization of Two Degradant Impurities in Bendamustine Hydrochloride Drug Product" @default.
- W1839259001 cites W1967971213 @default.
- W1839259001 cites W2000380218 @default.
- W1839259001 cites W2008411776 @default.
- W1839259001 cites W2014631400 @default.
- W1839259001 cites W2014663307 @default.
- W1839259001 cites W2018372223 @default.
- W1839259001 cites W2027730577 @default.
- W1839259001 cites W2049228165 @default.
- W1839259001 cites W2054789032 @default.
- W1839259001 cites W2054811026 @default.
- W1839259001 cites W2080843764 @default.
- W1839259001 cites W2083329993 @default.
- W1839259001 cites W2102198701 @default.
- W1839259001 cites W2125517757 @default.
- W1839259001 cites W2128936398 @default.
- W1839259001 cites W2131998596 @default.
- W1839259001 cites W4251235745 @default.
- W1839259001 doi "https://doi.org/10.1093/chromsci/bmv070" @default.
- W1839259001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26052090" @default.
- W1839259001 hasPublicationYear "2015" @default.
- W1839259001 type Work @default.
- W1839259001 sameAs 1839259001 @default.
- W1839259001 citedByCount "1" @default.
- W1839259001 countsByYear W18392590012022 @default.
- W1839259001 crossrefType "journal-article" @default.
- W1839259001 hasAuthorship W1839259001A5001633872 @default.
- W1839259001 hasAuthorship W1839259001A5002649486 @default.
- W1839259001 hasAuthorship W1839259001A5042346357 @default.
- W1839259001 hasAuthorship W1839259001A5058014567 @default.
- W1839259001 hasAuthorship W1839259001A5058533540 @default.
- W1839259001 hasAuthorship W1839259001A5072778953 @default.
- W1839259001 hasAuthorship W1839259001A5074592492 @default.
- W1839259001 hasAuthorship W1839259001A5080915473 @default.
- W1839259001 hasBestOaLocation W18392590011 @default.
- W1839259001 hasConcept C103319777 @default.
- W1839259001 hasConcept C126322002 @default.
- W1839259001 hasConcept C13965031 @default.
- W1839259001 hasConcept C178790620 @default.
- W1839259001 hasConcept C185592680 @default.
- W1839259001 hasConcept C2776460385 @default.
- W1839259001 hasConcept C2777819327 @default.
- W1839259001 hasConcept C2777938653 @default.
- W1839259001 hasConcept C2778461978 @default.
- W1839259001 hasConcept C2781442060 @default.
- W1839259001 hasConcept C43617362 @default.
- W1839259001 hasConcept C66974803 @default.
- W1839259001 hasConcept C71240020 @default.
- W1839259001 hasConcept C71924100 @default.
- W1839259001 hasConcept C71987851 @default.
- W1839259001 hasConceptScore W1839259001C103319777 @default.
- W1839259001 hasConceptScore W1839259001C126322002 @default.
- W1839259001 hasConceptScore W1839259001C13965031 @default.
- W1839259001 hasConceptScore W1839259001C178790620 @default.
- W1839259001 hasConceptScore W1839259001C185592680 @default.
- W1839259001 hasConceptScore W1839259001C2776460385 @default.
- W1839259001 hasConceptScore W1839259001C2777819327 @default.
- W1839259001 hasConceptScore W1839259001C2777938653 @default.
- W1839259001 hasConceptScore W1839259001C2778461978 @default.
- W1839259001 hasConceptScore W1839259001C2781442060 @default.
- W1839259001 hasConceptScore W1839259001C43617362 @default.
- W1839259001 hasConceptScore W1839259001C66974803 @default.
- W1839259001 hasConceptScore W1839259001C71240020 @default.
- W1839259001 hasConceptScore W1839259001C71924100 @default.
- W1839259001 hasConceptScore W1839259001C71987851 @default.
- W1839259001 hasIssue "10" @default.
- W1839259001 hasLocation W18392590011 @default.
- W1839259001 hasLocation W18392590012 @default.
- W1839259001 hasOpenAccess W1839259001 @default.
- W1839259001 hasPrimaryLocation W18392590011 @default.
- W1839259001 hasRelatedWork W113047186 @default.
- W1839259001 hasRelatedWork W1559044741 @default.
- W1839259001 hasRelatedWork W2297616538 @default.
- W1839259001 hasRelatedWork W2359461102 @default.
- W1839259001 hasRelatedWork W2362541710 @default.
- W1839259001 hasRelatedWork W2372416972 @default.
- W1839259001 hasRelatedWork W2374932470 @default.
- W1839259001 hasRelatedWork W2388416129 @default.
- W1839259001 hasRelatedWork W2690833630 @default.
- W1839259001 hasRelatedWork W4319315687 @default.
- W1839259001 hasVolume "53" @default.
- W1839259001 isParatext "false" @default.
- W1839259001 isRetracted "false" @default.
- W1839259001 magId "1839259001" @default.
- W1839259001 workType "article" @default.