Matches in SemOpenAlex for { <https://semopenalex.org/work/W1839264865> ?p ?o ?g. }
- W1839264865 endingPage "2406" @default.
- W1839264865 startingPage "2399" @default.
- W1839264865 abstract "Antimicrobial peptides are effector molecules of the innate immune system. We have recently shown that peptides containing multiples of the heparin‐binding Cardin and Weintraub motifs AKKARA and ARKKAAKA exert antimicrobial activities. Here, we show that replacement of lysine and arginine in these motifs by histidine abrogates the antibacterial effects of these peptides. Antibacterial activity of the histidine‐rich peptides against the Gram‐positive bacterium Enterococcus faecalis was restored by the addition of Zn 2+ . Fluorescence microscopy experiments showed that Zn 2+ enabled binding of the histidine‐rich peptides to Enterococcus faecalis bacteria. Similar Zn 2+ ‐dependent antibacterial activities were shown for histatin 5 as well as histidine‐containing peptides derived from the Zn 2+ ‐ and heparin‐binding domain 5 of human kininogen. Thus, the results demonstrate a previously undisclosed Zn 2+ ‐dependent antibacterial activity of kininogen‐derived peptides and indicate an important role for Zn 2+ in regulating the antimicrobial activities of histidine‐rich peptides." @default.
- W1839264865 created "2016-06-24" @default.
- W1839264865 creator A5035664022 @default.
- W1839264865 creator A5078258056 @default.
- W1839264865 creator A5082123381 @default.
- W1839264865 date "2006-05-08" @default.
- W1839264865 modified "2023-10-17" @default.
- W1839264865 title "Zinc potentiates the antibacterial effects of histidine-rich peptides against Enterococcus faecalis" @default.
- W1839264865 cites W1483785017 @default.
- W1839264865 cites W1923665285 @default.
- W1839264865 cites W1940255949 @default.
- W1839264865 cites W1941206325 @default.
- W1839264865 cites W1970621669 @default.
- W1839264865 cites W1977976729 @default.
- W1839264865 cites W1983521156 @default.
- W1839264865 cites W1983977223 @default.
- W1839264865 cites W1999137479 @default.
- W1839264865 cites W2008968208 @default.
- W1839264865 cites W2010999630 @default.
- W1839264865 cites W2018290030 @default.
- W1839264865 cites W2022577580 @default.
- W1839264865 cites W2024477522 @default.
- W1839264865 cites W2056598617 @default.
- W1839264865 cites W2057421073 @default.
- W1839264865 cites W2057549168 @default.
- W1839264865 cites W2068434462 @default.
- W1839264865 cites W2069693899 @default.
- W1839264865 cites W2079231292 @default.
- W1839264865 cites W2079468421 @default.
- W1839264865 cites W2082833445 @default.
- W1839264865 cites W2089175291 @default.
- W1839264865 cites W2092751827 @default.
- W1839264865 cites W2110521774 @default.
- W1839264865 cites W2113390782 @default.
- W1839264865 cites W2125539176 @default.
- W1839264865 cites W2137915101 @default.
- W1839264865 cites W2142504461 @default.
- W1839264865 cites W2144274119 @default.
- W1839264865 cites W2161584016 @default.
- W1839264865 cites W2397978929 @default.
- W1839264865 cites W4321509151 @default.
- W1839264865 doi "https://doi.org/10.1111/j.1742-4658.2006.05246.x" @default.
- W1839264865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16704414" @default.
- W1839264865 hasPublicationYear "2006" @default.
- W1839264865 type Work @default.
- W1839264865 sameAs 1839264865 @default.
- W1839264865 citedByCount "50" @default.
- W1839264865 countsByYear W18392648652012 @default.
- W1839264865 countsByYear W18392648652013 @default.
- W1839264865 countsByYear W18392648652014 @default.
- W1839264865 countsByYear W18392648652015 @default.
- W1839264865 countsByYear W18392648652017 @default.
- W1839264865 countsByYear W18392648652018 @default.
- W1839264865 countsByYear W18392648652019 @default.
- W1839264865 countsByYear W18392648652020 @default.
- W1839264865 countsByYear W18392648652021 @default.
- W1839264865 crossrefType "journal-article" @default.
- W1839264865 hasAuthorship W1839264865A5035664022 @default.
- W1839264865 hasAuthorship W1839264865A5078258056 @default.
- W1839264865 hasAuthorship W1839264865A5082123381 @default.
- W1839264865 hasBestOaLocation W18392648651 @default.
- W1839264865 hasConcept C104317684 @default.
- W1839264865 hasConcept C185592680 @default.
- W1839264865 hasConcept C2778460671 @default.
- W1839264865 hasConcept C2779281246 @default.
- W1839264865 hasConcept C2779895986 @default.
- W1839264865 hasConcept C2780104969 @default.
- W1839264865 hasConcept C2993778972 @default.
- W1839264865 hasConcept C4937899 @default.
- W1839264865 hasConcept C515207424 @default.
- W1839264865 hasConcept C523546767 @default.
- W1839264865 hasConcept C540938839 @default.
- W1839264865 hasConcept C54355233 @default.
- W1839264865 hasConcept C547475151 @default.
- W1839264865 hasConcept C55493867 @default.
- W1839264865 hasConcept C86803240 @default.
- W1839264865 hasConcept C89423630 @default.
- W1839264865 hasConceptScore W1839264865C104317684 @default.
- W1839264865 hasConceptScore W1839264865C185592680 @default.
- W1839264865 hasConceptScore W1839264865C2778460671 @default.
- W1839264865 hasConceptScore W1839264865C2779281246 @default.
- W1839264865 hasConceptScore W1839264865C2779895986 @default.
- W1839264865 hasConceptScore W1839264865C2780104969 @default.
- W1839264865 hasConceptScore W1839264865C2993778972 @default.
- W1839264865 hasConceptScore W1839264865C4937899 @default.
- W1839264865 hasConceptScore W1839264865C515207424 @default.
- W1839264865 hasConceptScore W1839264865C523546767 @default.
- W1839264865 hasConceptScore W1839264865C540938839 @default.
- W1839264865 hasConceptScore W1839264865C54355233 @default.
- W1839264865 hasConceptScore W1839264865C547475151 @default.
- W1839264865 hasConceptScore W1839264865C55493867 @default.
- W1839264865 hasConceptScore W1839264865C86803240 @default.
- W1839264865 hasConceptScore W1839264865C89423630 @default.
- W1839264865 hasIssue "11" @default.
- W1839264865 hasLocation W18392648651 @default.
- W1839264865 hasLocation W18392648652 @default.
- W1839264865 hasLocation W18392648653 @default.
- W1839264865 hasLocation W18392648654 @default.