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• W1839418165 startingPage "7771" @default.
• W1839418165 abstract "The lepromatous leprosy granuloma is a dynamic entity requiring a steady influx of macrophages (Mphi) for its maintenance. We have developed an in vitro model to study the fate of Mycobacterium leprae in a LL lesion, with and without immunotherapeutic intervention. Target cells, consisting of granuloma Mphi harvested from the footpads of M. leprae-infected athymic nu/nu mice, were cocultured with normal or IFN-gamma-activated (ACT) effector Mphi. The bacilli were recovered and assessed for viability by radiorespirometry. M. leprae recovered from target Mphi possessed high metabolic activity, indicating a viable state in this uncultivable organism. M. leprae recovered from target Mphi incubated with normal effector Mphi exhibited significantly higher metabolism. In contrast, bacilli recovered from target Mphi cocultured with ACT effector Mphi displayed a markedly decreased metabolic activity. Inhibition by ACT Mphi required an E:T ratio of at least 5:1, a coculture incubation period of 3-5 days, and the production of reactive nitrogen intermediates, but not reactive oxygen intermediates. Neither IFN-gamma nor TNF-alpha were required during the cocultivation period. However, cell-to-cell contact between the target and effector Mphi was necessary for augmentation of M. leprae metabolism by normal effector Mphi as well as for inhibition of M. leprae by ACT effector Mphi. Conventional fluorescence microscopy and confocal fluorescence microscopy revealed that the bacilli from the target Mphi were acquired by the effector Mphi. Thus, the state of Mphi infiltrating the granuloma may markedly affect the viability of M. leprae residing in Mphi in the lepromatous lesion." @default.
• W1839418165 created "2016-06-24" @default.
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• W1839418165 date "2004-06-15" @default.
• W1839418165 modified "2023-09-25" @default.
• W1839418165 title "An In Vitro Model for the Lepromatous Leprosy Granuloma: Fate of<i>Mycobacterium leprae</i>from Target Macrophages after Interaction with Normal and Activated Effector Macrophages" @default.
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• W1839418165 cites W1760231445 @default.
• W1839418165 cites W1762483199 @default.
• W1839418165 cites W1795419448 @default.
• W1839418165 cites W1827266985 @default.
• W1839418165 cites W1935775261 @default.
• W1839418165 cites W1968130780 @default.
• W1839418165 cites W1969747018 @default.
• W1839418165 cites W1970935798 @default.
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• W1839418165 cites W2007921117 @default.
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• W1839418165 cites W2054582722 @default.
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• W1839418165 doi "https://doi.org/10.4049/jimmunol.172.12.7771" @default.
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