FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1839597246> ?p ?o ?g. }

• W1839597246 abstract "Abstract The oxygen affinity of hemoglobin in K562 cells induced by hemin and the relationship between levels of 2,3-diphosphoglycerate (2,3-DPG) and hemoglobin have been investigated. Absorption spectra of induced cells indicate that the hemoglobin is oxygenated; oxygen dissociation curves are symmetric, with a P50 of 20 +/- 0.9 mm Hg, Hill coefficient of 2.5, and a normal temperature dependence. The intracellular pH measured by phosphorus 31 nuclear magnetic resonance (NMR) was 7.3. The amount of 2,3-DPG was determined by an enzymatic method and by 31P NMR. The level of 2,3-DPG in uninduced K562 cells, containing 0.5 pg of hemoglobin per cell, was low (5 +/- 0.5 mumole/10(8) cells), but increased to 64 +/- 5 mumole/10(8) cells upon induction of hemoglobin accumulation (to a final level of 20 pg hemoglobin/cell). For several experiments, there was a closely coordinated relationship between 2,3-DPG and hemoglobin levels, at about 1:1 stoichiometry of the two molecules. The time course of induction of hemoglobin, and of 2,3-DPG levels, are very similar; both processes are reversible. These data suggest that induction of hemoglobin synthesis in K562 cells by hemin results in hemoglobin-containing cells with normal oxygenation properties and that 2,3-DPG and hemoglobin levels are coordinately controlled in these cells. Elucidation of the mechanism of this effect should be of importance in understanding the erythroid-like differentiation of these cells." @default.
• W1839597246 created "2016-06-24" @default.
• W1839597246 creator A5006789693 @default.
• W1839597246 creator A5018191939 @default.
• W1839597246 creator A5047048178 @default.
• W1839597246 creator A5049521998 @default.
• W1839597246 date "1984-06-01" @default.
• W1839597246 modified "2023-09-30" @default.
• W1839597246 title "Control of oxygen affinity of hemoglobin in K562 cells induced by hemin" @default.
• W1839597246 cites W130020229 @default.
• W1839597246 cites W1526138335 @default.
• W1839597246 cites W1970415954 @default.
• W1839597246 cites W1974873429 @default.
• W1839597246 cites W1979627561 @default.
• W1839597246 cites W1991102898 @default.
• W1839597246 cites W1995200391 @default.
• W1839597246 cites W2005288797 @default.
• W1839597246 cites W2018181392 @default.
• W1839597246 cites W2025206980 @default.
• W1839597246 cites W2025449990 @default.
• W1839597246 cites W2026969402 @default.
• W1839597246 cites W2032948375 @default.
• W1839597246 cites W2059360988 @default.
• W1839597246 cites W2059628610 @default.
• W1839597246 cites W2063895135 @default.
• W1839597246 cites W2063939932 @default.
• W1839597246 cites W2066960428 @default.
• W1839597246 cites W2068065077 @default.
• W1839597246 cites W2080766637 @default.
• W1839597246 cites W2089743545 @default.
• W1839597246 cites W2281483869 @default.
• W1839597246 cites W2412498207 @default.
• W1839597246 cites W2463624460 @default.
• W1839597246 cites W253845798 @default.
• W1839597246 cites W601011139 @default.
• W1839597246 doi "https://doi.org/10.1182/blood.v63.6.1447.1447" @default.
• W1839597246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6202345" @default.
• W1839597246 hasPublicationYear "1984" @default.
• W1839597246 type Work @default.
• W1839597246 sameAs 1839597246 @default.
• W1839597246 citedByCount "4" @default.
• W1839597246 countsByYear W18395972462016 @default.
• W1839597246 countsByYear W18395972462018 @default.
• W1839597246 crossrefType "journal-article" @default.
• W1839597246 hasAuthorship W1839597246A5006789693 @default.
• W1839597246 hasAuthorship W1839597246A5018191939 @default.
• W1839597246 hasAuthorship W1839597246A5047048178 @default.
• W1839597246 hasAuthorship W1839597246A5049521998 @default.
• W1839597246 hasBestOaLocation W18395972461 @default.
• W1839597246 hasConcept C12554922 @default.
• W1839597246 hasConcept C1491633281 @default.
• W1839597246 hasConcept C171122931 @default.
• W1839597246 hasConcept C178790620 @default.
• W1839597246 hasConcept C181199279 @default.
• W1839597246 hasConcept C185592680 @default.
• W1839597246 hasConcept C20705724 @default.
• W1839597246 hasConcept C2776217839 @default.
• W1839597246 hasConcept C2777393523 @default.
• W1839597246 hasConcept C2777723881 @default.
• W1839597246 hasConcept C2778917026 @default.
• W1839597246 hasConcept C540031477 @default.
• W1839597246 hasConcept C55493867 @default.
• W1839597246 hasConcept C79879829 @default.
• W1839597246 hasConcept C86803240 @default.
• W1839597246 hasConceptScore W1839597246C12554922 @default.
• W1839597246 hasConceptScore W1839597246C1491633281 @default.
• W1839597246 hasConceptScore W1839597246C171122931 @default.
• W1839597246 hasConceptScore W1839597246C178790620 @default.
• W1839597246 hasConceptScore W1839597246C181199279 @default.
• W1839597246 hasConceptScore W1839597246C185592680 @default.
• W1839597246 hasConceptScore W1839597246C20705724 @default.
• W1839597246 hasConceptScore W1839597246C2776217839 @default.
• W1839597246 hasConceptScore W1839597246C2777393523 @default.
• W1839597246 hasConceptScore W1839597246C2777723881 @default.
• W1839597246 hasConceptScore W1839597246C2778917026 @default.
• W1839597246 hasConceptScore W1839597246C540031477 @default.
• W1839597246 hasConceptScore W1839597246C55493867 @default.
• W1839597246 hasConceptScore W1839597246C79879829 @default.
• W1839597246 hasConceptScore W1839597246C86803240 @default.
• W1839597246 hasLocation W18395972461 @default.
• W1839597246 hasOpenAccess W1839597246 @default.
• W1839597246 hasPrimaryLocation W18395972461 @default.
• W1839597246 hasRelatedWork W1542074894 @default.
• W1839597246 hasRelatedWork W1567117273 @default.
• W1839597246 hasRelatedWork W1639516662 @default.
• W1839597246 hasRelatedWork W1989225176 @default.
• W1839597246 hasRelatedWork W1997911154 @default.
• W1839597246 hasRelatedWork W2029463447 @default.
• W1839597246 hasRelatedWork W2040827348 @default.
• W1839597246 hasRelatedWork W2054214128 @default.
• W1839597246 hasRelatedWork W2057042656 @default.
• W1839597246 hasRelatedWork W2074646812 @default.
• W1839597246 hasRelatedWork W2076532230 @default.
• W1839597246 hasRelatedWork W2081767926 @default.
• W1839597246 hasRelatedWork W2110108884 @default.
• W1839597246 hasRelatedWork W2241797150 @default.
• W1839597246 hasRelatedWork W2407673837 @default.
• W1839597246 hasRelatedWork W2415979530 @default.
• W1839597246 hasRelatedWork W2426981627 @default.
• W1839597246 hasRelatedWork W2479204128 @default.

• next