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- W184031805 abstract "The ability of the selective cyclic μ-opioid receptor antagonist, (CTOP), to inhibit the acute and chronic effects of morphine in vivo was studied in mice. Intracerebroventricular (i.c.v.) administration of CTOP antagonized the analgesic effect of morphine in a dose-dependent manner, as measured by the heat-irradiant (tail-flick) method. CTOP was more effective than naloxone in inhibiting analgesia on a molar basis. CTOP also antagonized the acute morphine-induced hypermotility. CTOP caused withdrawal hypothermia and a loss of body weight in morphine-dependent animals. After the development of morphine-induced chronic dependence, CTOP administered i.c.v. caused a dose-dependent loss of body weight and hypothermia, and was about 10–400 times more potent than naloxone. CTOP administered alone to drugnaive mice did not cause antinociception, changes in body weight or body temperature." @default.
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- W184031805 date "1988-06-01" @default.
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- W184031805 title "Central effects of the potent and highly selective μ opioid antagonist (CTOP) in mice" @default.
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- W184031805 doi "https://doi.org/10.1016/0014-2999(88)90018-0" @default.
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