FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1840363948> ?p ?o ?g. }

• W1840363948 abstract "The centromere-kinetochore complex can be divided into distinct domains based on structure and function. Previous work has used CREST auto-antibodies with various microscopic techniques to map the locations of proteins within the centromere-kinetochore complex and to analyze the maturation of prekinetochores before mitosis. Here we have focused on the centromere-specific histone Centromere Protein (CENP)-A and its spatial relationship to other histones and histone modifications found in condensed chromatin. We demonstrate that the phosphorylation of histone H3 is essentially excluded from a specific region of centromeric chromatin, defined by the presence of CENP-A. Interspersion of CENP-B with phosphorylated H3 in the inner centromere indicates that the exclusion of H3 modification is not a general property of alpha-satellite DNA. We also demonstrate that these regions are functionally distinct by fragmenting mitotic chromatin into motile centromere-kinetochore fragments that contain CENP-A with little or no phosphorylated H3 and nonmotile fragments that contain exclusively phosphorylated H3. The sequence of CENP-A diverges from H3 in a number of key residues involved in chromosome condensation and in transcription, potentially allowing a more specialized chromatin structure within centromeric heterochromatin, on which kinetochore plates may nucleate and mature. This specialized centromere subdomain would be predicted to have a very tight and static nucleosome structure as a result of the absence of H3 phosphorylation and acetylation." @default.
• W1840363948 created "2016-06-24" @default.
• W1840363948 creator A5017428450 @default.
• W1840363948 creator A5034689335 @default.
• W1840363948 creator A5052967210 @default.
• W1840363948 creator A5063372896 @default.
• W1840363948 creator A5070135589 @default.
• W1840363948 date "1999-12-01" @default.
• W1840363948 modified "2023-10-17" @default.
• W1840363948 title "The mammalian centromere: structural domains and the attenuation of chromatin modeling" @default.
• W1840363948 cites W1532980594 @default.
• W1840363948 cites W1601890318 @default.
• W1840363948 cites W1969588285 @default.
• W1840363948 cites W1982174395 @default.
• W1840363948 cites W1985064850 @default.
• W1840363948 cites W1987352006 @default.
• W1840363948 cites W1990511818 @default.
• W1840363948 cites W1992591418 @default.
• W1840363948 cites W1993220753 @default.
• W1840363948 cites W1996978236 @default.
• W1840363948 cites W1998220537 @default.
• W1840363948 cites W2008435997 @default.
• W1840363948 cites W2010649437 @default.
• W1840363948 cites W2015285602 @default.
• W1840363948 cites W2017920584 @default.
• W1840363948 cites W2019383556 @default.
• W1840363948 cites W2026443391 @default.
• W1840363948 cites W2035143633 @default.
• W1840363948 cites W2039428192 @default.
• W1840363948 cites W2048109276 @default.
• W1840363948 cites W2048410445 @default.
• W1840363948 cites W2051242796 @default.
• W1840363948 cites W2055486450 @default.
• W1840363948 cites W2066884369 @default.
• W1840363948 cites W2067153190 @default.
• W1840363948 cites W2068032875 @default.
• W1840363948 cites W2081736956 @default.
• W1840363948 cites W2081761746 @default.
• W1840363948 cites W2084413077 @default.
• W1840363948 cites W2086081150 @default.
• W1840363948 cites W2087200075 @default.
• W1840363948 cites W2098141162 @default.
• W1840363948 cites W2108688550 @default.
• W1840363948 cites W2112880795 @default.
• W1840363948 cites W2121989845 @default.
• W1840363948 cites W2138882380 @default.
• W1840363948 cites W2139736965 @default.
• W1840363948 cites W2145921551 @default.
• W1840363948 cites W2148430914 @default.
• W1840363948 cites W2155235554 @default.
• W1840363948 cites W2155716214 @default.
• W1840363948 cites W2314888598 @default.
• W1840363948 doi "https://doi.org/10.1096/fasebj.13.9002.s216" @default.
• W1840363948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10619130" @default.
• W1840363948 hasPublicationYear "1999" @default.
• W1840363948 type Work @default.
• W1840363948 sameAs 1840363948 @default.
• W1840363948 citedByCount "35" @default.
• W1840363948 countsByYear W18403639482012 @default.
• W1840363948 countsByYear W18403639482016 @default.
• W1840363948 countsByYear W18403639482017 @default.
• W1840363948 countsByYear W18403639482020 @default.
• W1840363948 crossrefType "journal-article" @default.
• W1840363948 hasAuthorship W1840363948A5017428450 @default.
• W1840363948 hasAuthorship W1840363948A5034689335 @default.
• W1840363948 hasAuthorship W1840363948A5052967210 @default.
• W1840363948 hasAuthorship W1840363948A5063372896 @default.
• W1840363948 hasAuthorship W1840363948A5070135589 @default.
• W1840363948 hasConcept C104317684 @default.
• W1840363948 hasConcept C141937037 @default.
• W1840363948 hasConcept C192838845 @default.
• W1840363948 hasConcept C2776745794 @default.
• W1840363948 hasConcept C30481170 @default.
• W1840363948 hasConcept C54355233 @default.
• W1840363948 hasConcept C552990157 @default.
• W1840363948 hasConcept C63491729 @default.
• W1840363948 hasConcept C64927066 @default.
• W1840363948 hasConcept C83640560 @default.
• W1840363948 hasConcept C84772758 @default.
• W1840363948 hasConcept C86803240 @default.
• W1840363948 hasConcept C95444343 @default.
• W1840363948 hasConceptScore W1840363948C104317684 @default.
• W1840363948 hasConceptScore W1840363948C141937037 @default.
• W1840363948 hasConceptScore W1840363948C192838845 @default.
• W1840363948 hasConceptScore W1840363948C2776745794 @default.
• W1840363948 hasConceptScore W1840363948C30481170 @default.
• W1840363948 hasConceptScore W1840363948C54355233 @default.
• W1840363948 hasConceptScore W1840363948C552990157 @default.
• W1840363948 hasConceptScore W1840363948C63491729 @default.
• W1840363948 hasConceptScore W1840363948C64927066 @default.
• W1840363948 hasConceptScore W1840363948C83640560 @default.
• W1840363948 hasConceptScore W1840363948C84772758 @default.
• W1840363948 hasConceptScore W1840363948C86803240 @default.
• W1840363948 hasConceptScore W1840363948C95444343 @default.
• W1840363948 hasFunder F4320332161 @default.
• W1840363948 hasFunder F4320337351 @default.
• W1840363948 hasIssue "9002" @default.
• W1840363948 hasLocation W18403639481 @default.
• W1840363948 hasLocation W18403639482 @default.
• W1840363948 hasOpenAccess W1840363948 @default.

• next