FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W184045013> ?p ?o ?g. }

• W184045013 endingPage "83" @default.
• W184045013 startingPage "79" @default.
• W184045013 abstract "Type-2 diabetes mellitus (T2DM) is a global disease and its resultant complication, diabetic nephropathy, is a leading cause of chronic renal failure. Microalbuminuria is an early indicator of diabetic nephropathy and is also an independent risk factor for cardiovascular morbidity. Data have shown that anti-hypertensives like Angiotensin receptor blockers (ARB), and Angiotensin converting enzyme inhibitors (ACEI) reduce microalbuminuria and retards the progression of renal disease effectively in hypertensive T2DM patients. But the effects ofARBs on preventing microalbuminuria and ensuing nephropathy in normotensive patients with T2DM is yet to be fully established. To assess the anti-microalbuminuric effects of losartan therapy in normotensive T2DM patients. Interventional Phase Two Clinical Trial was done. Study was done at Diabetic Clinic, Jinnah Hospital Lahore, Pakistan over 8 months. A total of 171 normotensive patients with T2DM and microalbuminuria were evaluated. After informed consent and baseline 24-hour urinary microalbuminuria quantification the selected patients were started on losartan 50 mg/day for a six-month period. Monthly follow-ups were done to monitor the blood pressure, glycemic control, urea/creatinine/potassium levels and any untoward effects of losartan therapy. Quantitative microalbuminuria was repeated at the end of study. Out of the 171 patients, 149 (87.1%) had significant albuminuria reduction >30.0% of their baseline and the variable of final outcome of intervention (urinary albumin in mg/dl) was significantly reduced (Mean 101.9 +/- SD 21.7 baseline and 47.5 +/- 12.9 post therapy) with p<0.001 and with minimal side-effects. These anti-albuminuric effects of losartan were reversible as seen on rechecking the urinary albumin two months after discontinuation of treatment. Losartan was well tolerated and demonstrated significant anti-proteinuric effects in patients with T2DM with early nephropathy independent of hypertension, warranting further long-term large-scale studies to prove its usefulness as preventive therapy for diabetic nephropathy." @default.
• W184045013 created "2016-06-24" @default.
• W184045013 creator A5038607815 @default.
• W184045013 creator A5053708903 @default.
• W184045013 creator A5079545326 @default.
• W184045013 date "2007-06-01" @default.
• W184045013 modified "2023-09-24" @default.
• W184045013 title "Use of losartan in reducing microalbuminuria in normotensive patients with type-2 diabetes mellitus." @default.
• W184045013 cites W1830527160 @default.
• W184045013 cites W1968446955 @default.
• W184045013 cites W1977075739 @default.
• W184045013 cites W1977269859 @default.
• W184045013 cites W1999917583 @default.
• W184045013 cites W2002080901 @default.
• W184045013 cites W2004164169 @default.
• W184045013 cites W2020267609 @default.
• W184045013 cites W2024635091 @default.
• W184045013 cites W2044773944 @default.
• W184045013 cites W2046809996 @default.
• W184045013 cites W2047680488 @default.
• W184045013 cites W2056976690 @default.
• W184045013 cites W2057105818 @default.
• W184045013 cites W2064568136 @default.
• W184045013 cites W2064927835 @default.
• W184045013 cites W2088462304 @default.
• W184045013 cites W2097288698 @default.
• W184045013 cites W2098154750 @default.
• W184045013 cites W2101337813 @default.
• W184045013 cites W2104916280 @default.
• W184045013 cites W2114026537 @default.
• W184045013 cites W2118286022 @default.
• W184045013 cites W2133568993 @default.
• W184045013 cites W2185279615 @default.
• W184045013 cites W2203067263 @default.
• W184045013 cites W2332607769 @default.
• W184045013 cites W2408042400 @default.
• W184045013 cites W2442062721 @default.
• W184045013 cites W2529012027 @default.
• W184045013 cites W2003670762 @default.
• W184045013 cites W2296903449 @default.
• W184045013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17899953" @default.
• W184045013 hasPublicationYear "2007" @default.
• W184045013 type Work @default.
• W184045013 sameAs 184045013 @default.
• W184045013 citedByCount "2" @default.
• W184045013 countsByYear W1840450132015 @default.
• W184045013 countsByYear W1840450132019 @default.
• W184045013 crossrefType "journal-article" @default.
• W184045013 hasAuthorship W184045013A5038607815 @default.
• W184045013 hasAuthorship W184045013A5053708903 @default.
• W184045013 hasAuthorship W184045013A5079545326 @default.
• W184045013 hasConcept C126322002 @default.
• W184045013 hasConcept C126894567 @default.
• W184045013 hasConcept C134018914 @default.
• W184045013 hasConcept C2776174234 @default.
• W184045013 hasConcept C2779922275 @default.
• W184045013 hasConcept C2780288358 @default.
• W184045013 hasConcept C2781203188 @default.
• W184045013 hasConcept C2908929049 @default.
• W184045013 hasConcept C2910068830 @default.
• W184045013 hasConcept C555293320 @default.
• W184045013 hasConcept C71924100 @default.
• W184045013 hasConcept C84393581 @default.
• W184045013 hasConceptScore W184045013C126322002 @default.
• W184045013 hasConceptScore W184045013C126894567 @default.
• W184045013 hasConceptScore W184045013C134018914 @default.
• W184045013 hasConceptScore W184045013C2776174234 @default.
• W184045013 hasConceptScore W184045013C2779922275 @default.
• W184045013 hasConceptScore W184045013C2780288358 @default.
• W184045013 hasConceptScore W184045013C2781203188 @default.
• W184045013 hasConceptScore W184045013C2908929049 @default.
• W184045013 hasConceptScore W184045013C2910068830 @default.
• W184045013 hasConceptScore W184045013C555293320 @default.
• W184045013 hasConceptScore W184045013C71924100 @default.
• W184045013 hasConceptScore W184045013C84393581 @default.
• W184045013 hasIssue "2" @default.
• W184045013 hasLocation W1840450131 @default.
• W184045013 hasLocation W1840450132 @default.
• W184045013 hasOpenAccess W184045013 @default.
• W184045013 hasPrimaryLocation W1840450131 @default.
• W184045013 hasRelatedWork W1975768263 @default.
• W184045013 hasRelatedWork W1980014931 @default.
• W184045013 hasRelatedWork W2000154505 @default.
• W184045013 hasRelatedWork W2017268330 @default.
• W184045013 hasRelatedWork W2034269429 @default.
• W184045013 hasRelatedWork W2059792416 @default.
• W184045013 hasRelatedWork W2073547343 @default.
• W184045013 hasRelatedWork W2091262290 @default.
• W184045013 hasRelatedWork W2110837983 @default.
• W184045013 hasRelatedWork W2113031087 @default.
• W184045013 hasRelatedWork W2113961225 @default.
• W184045013 hasRelatedWork W2119431414 @default.
• W184045013 hasRelatedWork W2292645742 @default.
• W184045013 hasRelatedWork W2359443551 @default.
• W184045013 hasRelatedWork W2372105123 @default.
• W184045013 hasRelatedWork W2513565107 @default.
• W184045013 hasRelatedWork W2622028093 @default.
• W184045013 hasRelatedWork W2954234894 @default.

• next