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• W1840677323 endingPage "1210" @default.
• W1840677323 startingPage "1201" @default.
• W1840677323 abstract "Maintaining accurate progression through the cell cycle requires the proper temporal expression and regulation of cyclins. The mammalian D-type cyclins promote G1-S transition. D1 cyclin protein stability is regulated through its ubiquitylation and resulting proteolysis catalyzed by the SCF E3 ubiquitin ligase complex containing the F-box protein, Fbx4. SCF E3-ligase-dependent ubiquitylation of D1 is trigged by an increase in the phosphorylation status of the cyclin. As inhibition of ubiquitin-dependent D1 degradation is seen in many human cancers, we set out to uncover how D-type cyclin phosphorylation is regulated. Here we show that in S. cerevisiae, a heterotrimeric protein phosphatase 2A (PP2A(Cdc55)) containing the mammalian PPP2R2/PR55 B subunit ortholog Cdc55 regulates the stability of the G1 cyclin Cln2 by directly regulating its phosphorylation state. Cells lacking Cdc55 contain drastically reduced Cln2 levels caused by degradation due to cdk-dependent hyperphosphorylation, as a Cln2 mutant unable to be phosphorylated by the yeast cdk Cdc28 is highly stable in cdc55-null cells. Moreover, cdc55-null cells become inviable when the SCF(Grr1) activity known to regulate Cln2 levels is eliminated or when Cln2 is overexpressed, indicating a critical relationship between SCF and PP2A functions in regulating cell cycle progression through modulation of G1-S cyclin degradation/stability. In sum, our results indicate that PP2A is absolutely required to maintain G1-S cyclin levels through modulating their phosphorylation status, an event necessary to properly transit through the cell cycle." @default.
• W1840677323 created "2016-06-24" @default.
• W1840677323 creator A5003550595 @default.
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• W1840677323 creator A5061116054 @default.
• W1840677323 creator A5088471454 @default.
• W1840677323 date "2013-04-15" @default.
• W1840677323 modified "2023-09-25" @default.
• W1840677323 title "PP2A^Cdc55regulates G₁cyclin stability" @default.
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• W1840677323 doi "https://doi.org/10.4161/cc.24231" @default.
• W1840677323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3674085" @default.
• W1840677323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23518505" @default.
• W1840677323 hasPublicationYear "2013" @default.
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