FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1840783721> ?p ?o ?g. }

• W1840783721 endingPage "916" @default.
• W1840783721 startingPage "911" @default.
• W1840783721 abstract "(15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid (15-HETE) suppresses in ionophore-A23187-stimulated human polymorphonuclear leucocytes (PMN) the conversion of exogenous arachidonic acid into leukotriene B(4) (LTB4) and (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid (5-HETE). However, contrary to earlier suggestions, 15-HETE is not a genuine 5-lipoxygenase inhibitor under these conditions, but rather suppresses the 5-lipoxygenation of arachidonic acid by switching-over of substrate utilization, as judged from a sizeable formation of labelled (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetr aen oic acid (5,15-diHETE) from 15-[1(-14)C]HETE. Identical results were obtained with human recombinant 5-lipoxygenase. In PMN the formation of 5,15-diHETE is strongly stimulated by either hydroperoxypolyenoic fatty acids or arachidonic acid, suggesting a crucial role of the hydroperoxide tone of the cell. A comparison of a selection of hydroxypolyenoic fatty acids with respect to their capability of suppressing 5-lipoxygenation of arachidonic acid revealed that 15-mono-hydroxyeicosanoids throughout exhibit the highest inhibitory potencies, whereas the other HETEs, 5,15-diHETE as well as octadecanoids, are modest or poor inhibitors. The R and S enantiomers of 15-HETE do not differ from each other, excluding a receptor-like binding of the 15-hydroxy group." @default.
• W1840783721 created "2016-06-24" @default.
• W1840783721 creator A5012161402 @default.
• W1840783721 creator A5019799865 @default.
• W1840783721 creator A5034111332 @default.
• W1840783721 creator A5064301762 @default.
• W1840783721 date "1996-03-15" @default.
• W1840783721 modified "2023-10-16" @default.
• W1840783721 title "The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15<i>S</i>)-hydroxy-(5<i>Z</i>,8<i>Z</i>,11<i>Z</i>,13<i>E</i>)-eicosatetraenoic acid: structure-activity relationship and mechanism of action" @default.
• W1840783721 cites W1494579587 @default.
• W1840783721 cites W1517088677 @default.
• W1840783721 cites W1529804537 @default.
• W1840783721 cites W1602936320 @default.
• W1840783721 cites W1605709450 @default.
• W1840783721 cites W1615557421 @default.
• W1840783721 cites W1864533597 @default.
• W1840783721 cites W1942988316 @default.
• W1840783721 cites W1965254827 @default.
• W1840783721 cites W1978020663 @default.
• W1840783721 cites W1986703846 @default.
• W1840783721 cites W1994817640 @default.
• W1840783721 cites W2003890116 @default.
• W1840783721 cites W2009641749 @default.
• W1840783721 cites W2018883862 @default.
• W1840783721 cites W2019353213 @default.
• W1840783721 cites W2022321693 @default.
• W1840783721 cites W2023472160 @default.
• W1840783721 cites W2024176341 @default.
• W1840783721 cites W2024297591 @default.
• W1840783721 cites W2025100002 @default.
• W1840783721 cites W2025526159 @default.
• W1840783721 cites W2053561286 @default.
• W1840783721 cites W2059959435 @default.
• W1840783721 cites W2077966190 @default.
• W1840783721 cites W2086307811 @default.
• W1840783721 cites W2090805356 @default.
• W1840783721 cites W2094579931 @default.
• W1840783721 cites W2095435791 @default.
• W1840783721 cites W2121737195 @default.
• W1840783721 cites W2399878865 @default.
• W1840783721 cites W2403004569 @default.
• W1840783721 cites W2414835269 @default.
• W1840783721 cites W2418200004 @default.
• W1840783721 doi "https://doi.org/10.1042/bj3140911" @default.
• W1840783721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1217143" @default.
• W1840783721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8615788" @default.
• W1840783721 hasPublicationYear "1996" @default.
• W1840783721 type Work @default.
• W1840783721 sameAs 1840783721 @default.
• W1840783721 citedByCount "40" @default.
• W1840783721 countsByYear W18407837212012 @default.
• W1840783721 countsByYear W18407837212014 @default.
• W1840783721 countsByYear W18407837212015 @default.
• W1840783721 countsByYear W18407837212016 @default.
• W1840783721 countsByYear W18407837212017 @default.
• W1840783721 countsByYear W18407837212020 @default.
• W1840783721 countsByYear W18407837212021 @default.
• W1840783721 countsByYear W18407837212022 @default.
• W1840783721 countsByYear W18407837212023 @default.
• W1840783721 crossrefType "journal-article" @default.
• W1840783721 hasAuthorship W1840783721A5012161402 @default.
• W1840783721 hasAuthorship W1840783721A5019799865 @default.
• W1840783721 hasAuthorship W1840783721A5034111332 @default.
• W1840783721 hasAuthorship W1840783721A5064301762 @default.
• W1840783721 hasBestOaLocation W18407837212 @default.
• W1840783721 hasConcept C181199279 @default.
• W1840783721 hasConcept C185592680 @default.
• W1840783721 hasConcept C18903297 @default.
• W1840783721 hasConcept C203014093 @default.
• W1840783721 hasConcept C2776042228 @default.
• W1840783721 hasConcept C2776452501 @default.
• W1840783721 hasConcept C2776685179 @default.
• W1840783721 hasConcept C2776914184 @default.
• W1840783721 hasConcept C2777289219 @default.
• W1840783721 hasConcept C2778078955 @default.
• W1840783721 hasConcept C2779630222 @default.
• W1840783721 hasConcept C2780857362 @default.
• W1840783721 hasConcept C486523 @default.
• W1840783721 hasConcept C543025807 @default.
• W1840783721 hasConcept C55493867 @default.
• W1840783721 hasConcept C71240020 @default.
• W1840783721 hasConcept C86803240 @default.
• W1840783721 hasConcept C90342290 @default.
• W1840783721 hasConceptScore W1840783721C181199279 @default.
• W1840783721 hasConceptScore W1840783721C185592680 @default.
• W1840783721 hasConceptScore W1840783721C18903297 @default.
• W1840783721 hasConceptScore W1840783721C203014093 @default.
• W1840783721 hasConceptScore W1840783721C2776042228 @default.
• W1840783721 hasConceptScore W1840783721C2776452501 @default.
• W1840783721 hasConceptScore W1840783721C2776685179 @default.
• W1840783721 hasConceptScore W1840783721C2776914184 @default.
• W1840783721 hasConceptScore W1840783721C2777289219 @default.
• W1840783721 hasConceptScore W1840783721C2778078955 @default.
• W1840783721 hasConceptScore W1840783721C2779630222 @default.
• W1840783721 hasConceptScore W1840783721C2780857362 @default.
• W1840783721 hasConceptScore W1840783721C486523 @default.
• W1840783721 hasConceptScore W1840783721C543025807 @default.
• W1840783721 hasConceptScore W1840783721C55493867 @default.

• next