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• W1840806497 abstract "The role of the Na + /H + exchanger in rat hearts during ischemia and reperfusion was investigated by measurements of intracellular Na + concentration ([Na + ] i ) and intracellular and extracellular pH. Under our standard conditions (2-Hz stimulation), 10 min of ischemia caused no significant rise in [Na + ] i but an acidosis of 1.0 pH unit, suggesting that the Na + /H + exchanger was inactive during ischemia. This was confirmed by showing that the Na + /H + exchange inhibitor methylisobutyl amiloride (MIA) had no effect on [Na + ] i or on intracellular pH during ischemia. However, there was a short-lived increase in [Na + ] i of 8.2 ± 0.6 mM on reperfusion, which was reduced by MIA, showing that the Na + /H + exchanger became active on reperfusion. To investigate the role of metabolic changes, we measured [Na + ] i during anoxia. The [Na + ] i did not change during 10 min of anoxia, but there was a small, transient rise of [Na + ] i on reoxygenation, which was inhibited by MIA. In addition, we show that the Na + /H + exchanger, tested by sodium lactate exposure, was inhibited during anoxia. These results show that the Na + /H + exchanger is inhibited during ischemia and anoxia, probably by an intracellular metabolic mechanism. The exchanger activates rapidly on reperfusion and can cause a rapid rise in [Na + ] i ." @default.
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• W1840806497 date "1999-05-01" @default.
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• W1840806497 title "Changes in intracellular Na⁺and pH in rat heart during ischemia: role of Na⁺/H⁺exchanger" @default.
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• W1840806497 doi "https://doi.org/10.1152/ajpheart.1999.276.5.h1581" @default.
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