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• W1840861722 abstract "J. Neurochem. (2010) 115, 1234–1244. Abstract d-Aspartate (d-Asp) is an endogenous molecule that is often detected in CNS and endocrine tissues. Using capillary electrophoresis and a variety of radionuclide detection techniques, we examine the synthesis, release, and uptake/accumulation of d-Asp in the CNS of the marine mollusk Aplysia californica. We observe the preferential synthesis and accumulation of d-Asp over l-aspartate (l-Asp) in neuron-containing ganglia compared to surrounding sheath tissues. Little conversion of d-Asp to l-Asp is detected. The Ca2+ ionophore ionomycin and elevated extracellular potassium stimulates release of d-Asp from the cerebral ganglia. Lastly, radioactive d-Asp in the extracellular media is efficiently taken up and accumulated by individual F-cluster neurons. These observations point to a role for d-Asp in cell-to-cell signaling with many characteristics similar to classical transmitters." @default.
• W1840861722 created "2016-06-24" @default.
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• W1840861722 date "2010-10-21" @default.
• W1840861722 modified "2023-09-23" @default.
• W1840861722 title "Synthesis, accumulation, and release of d-aspartate in the Aplysia californica CNS" @default.
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• W1840861722 doi "https://doi.org/10.1111/j.1471-4159.2010.07020.x" @default.
• W1840861722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2972370" @default.
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