FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1840881871> ?p ?o ?g. }

• W1840881871 endingPage "940" @default.
• W1840881871 startingPage "931" @default.
• W1840881871 abstract "Glaucoma, a blinding neurodegenerative disease, whose risk factors include elevated intraocular pressure (IOP), age, and genetics, is characterized by accelerated and progressive retinal ganglion cell (RGC) death. Despite decades of research, the mechanism of RGC death in glaucoma is still unknown. Here, we demonstrate that the genetic effect of the SIX6 risk variant (rs33912345, His141Asn) is enhanced by another major POAG risk gene, p16INK4a (cyclin-dependent kinase inhibitor 2A, isoform INK4a). We further show that the upregulation of homozygous SIX6 risk alleles (CC) leads to an increase in p16INK4a expression, with subsequent cellular senescence, as evidenced in a mouse model of elevated IOP and in human POAG eyes. Our data indicate that SIX6 and/or IOP promotes POAG by directly increasing p16INK4a expression, leading to RGC senescence in adult human retinas. Our study provides important insights linking genetic susceptibility to the underlying mechanism of RGC death and provides a unified theory of glaucoma pathogenesis." @default.
• W1840881871 created "2016-06-24" @default.
• W1840881871 creator A5000068004 @default.
• W1840881871 creator A5001513312 @default.
• W1840881871 creator A5005424495 @default.
• W1840881871 creator A5007935489 @default.
• W1840881871 creator A5011388287 @default.
• W1840881871 creator A5015479816 @default.
• W1840881871 creator A5022962900 @default.
• W1840881871 creator A5024124240 @default.
• W1840881871 creator A5026057502 @default.
• W1840881871 creator A5028289735 @default.
• W1840881871 creator A5028880819 @default.
• W1840881871 creator A5031543598 @default.
• W1840881871 creator A5031936679 @default.
• W1840881871 creator A5036036576 @default.
• W1840881871 creator A5036660260 @default.
• W1840881871 creator A5043994887 @default.
• W1840881871 creator A5046171973 @default.
• W1840881871 creator A5047170729 @default.
• W1840881871 creator A5047976044 @default.
• W1840881871 creator A5049594879 @default.
• W1840881871 creator A5050968979 @default.
• W1840881871 creator A5053139475 @default.
• W1840881871 creator A5055970408 @default.
• W1840881871 creator A5057506229 @default.
• W1840881871 creator A5059601831 @default.
• W1840881871 creator A5062140609 @default.
• W1840881871 creator A5064101943 @default.
• W1840881871 creator A5064591852 @default.
• W1840881871 creator A5067541352 @default.
• W1840881871 creator A5068312783 @default.
• W1840881871 creator A5068365109 @default.
• W1840881871 creator A5069372801 @default.
• W1840881871 creator A5071258270 @default.
• W1840881871 creator A5074902671 @default.
• W1840881871 creator A5075883536 @default.
• W1840881871 creator A5079263990 @default.
• W1840881871 creator A5081266476 @default.
• W1840881871 creator A5083005519 @default.
• W1840881871 creator A5087081419 @default.
• W1840881871 date "2015-09-01" @default.
• W1840881871 modified "2023-10-12" @default.
• W1840881871 title "P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma" @default.
• W1840881871 cites W1486289153 @default.
• W1840881871 cites W1502620559 @default.
• W1840881871 cites W1967681080 @default.
• W1840881871 cites W1968210590 @default.
• W1840881871 cites W1991938143 @default.
• W1840881871 cites W2002698073 @default.
• W1840881871 cites W2003975744 @default.
• W1840881871 cites W2020684034 @default.
• W1840881871 cites W2031162730 @default.
• W1840881871 cites W2034742711 @default.
• W1840881871 cites W2039771390 @default.
• W1840881871 cites W2040250052 @default.
• W1840881871 cites W2049085719 @default.
• W1840881871 cites W2056008826 @default.
• W1840881871 cites W2056643682 @default.
• W1840881871 cites W2061952501 @default.
• W1840881871 cites W2069519394 @default.
• W1840881871 cites W2073429636 @default.
• W1840881871 cites W2076003960 @default.
• W1840881871 cites W2077772514 @default.
• W1840881871 cites W2092333751 @default.
• W1840881871 cites W2101276900 @default.
• W1840881871 cites W2102871449 @default.
• W1840881871 cites W2105683805 @default.
• W1840881871 cites W2106523452 @default.
• W1840881871 cites W2106901733 @default.
• W1840881871 cites W2114258524 @default.
• W1840881871 cites W2114677179 @default.
• W1840881871 cites W2122563776 @default.
• W1840881871 cites W2125578099 @default.
• W1840881871 cites W2136328165 @default.
• W1840881871 cites W2143025202 @default.
• W1840881871 cites W2145192598 @default.
• W1840881871 cites W2147183816 @default.
• W1840881871 cites W2150748567 @default.
• W1840881871 cites W2151459533 @default.
• W1840881871 cites W2161633633 @default.
• W1840881871 cites W2164044753 @default.
• W1840881871 cites W2166846288 @default.
• W1840881871 doi "https://doi.org/10.1016/j.molcel.2015.07.027" @default.
• W1840881871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4648709" @default.
• W1840881871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26365380" @default.
• W1840881871 hasPublicationYear "2015" @default.
• W1840881871 type Work @default.
• W1840881871 sameAs 1840881871 @default.
• W1840881871 citedByCount "57" @default.
• W1840881871 countsByYear W18408818712015 @default.
• W1840881871 countsByYear W18408818712016 @default.
• W1840881871 countsByYear W18408818712017 @default.
• W1840881871 countsByYear W18408818712018 @default.
• W1840881871 countsByYear W18408818712019 @default.
• W1840881871 countsByYear W18408818712020 @default.
• W1840881871 countsByYear W18408818712021 @default.
• W1840881871 countsByYear W18408818712022 @default.

• next