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- W1840897681 endingPage "438" @default.
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- W1840897681 abstract "In the treatment of HIV infections to prevent AIDS, the focus now is to discover substances that can interfere with the reproduction of HIV, and for which the virus have little propensity for resistance. Of course, the material must have appropriate features that favor its usage as a drug, including a deliverable formulation, reasonable bioavailability, attainment of effective plasma concentrations, low toxicity, and others. This chapter describes the various methods used to identify novel antiviral materials effective against HIV, studies to characterize a newly discovered active compound with respect to its range and mechanism of action, and in vitro studies employed to anticipate the pharmacological potential of the compound as a useful drug. The goal of developing an effective drug against HIV-1 and AIDS has been approached by several routes, with enough encouraging results to stimulate further efforts. Although the final test of a drug's efficacy comes in the clinical experience, submission of an antiviral compound to an in vitro developmental gauntlet can save much time, effort, expense, and human resource in the in vivo developmental regimen required prior to human use." @default.
- W1840897681 created "2016-06-24" @default.
- W1840897681 creator A5024503165 @default.
- W1840897681 creator A5087410485 @default.
- W1840897681 date "1995-01-01" @default.
- W1840897681 modified "2023-10-18" @default.
- W1840897681 title "Discovery and in Vitro Development of AIDS Antiviral Drugs as Biopharmaceuticals" @default.
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