FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1841303832> ?p ?o ?g. }

• W1841303832 endingPage "20" @default.
• W1841303832 startingPage "10" @default.
• W1841303832 abstract "The increased production of amyloid β-peptide (Aβ) in Alzheimer's disease is acknowledged to be a key pathogenic event. In this study, we examined the response of primary human and rat brain cortical cultures to Aβ administration and found a marked increase in the tyrosine phosphorylation content of numerous neuronal proteins, including tau and putative microtubule-associated protein 2c (MAP2c). We also found that paired helical filaments of aggregated and hyperphosphorylated tau are tyrosine phosphorylated, indicating that changes in the phosphotyrosine content of cytoplasmic proteins in response to Aβ are potentially an important process. Increased tyrosine phosphorylation of cytoskeletal and other neuronal proteins was specific to fibrillar Aβ 25–35 and Aβ 1–42 . The tyrosine phosphorylation was blocked by addition of the Src family tyrosine kinase inhibitor 4-amino-5-(4-chlorophenyl)-7( t -butyl)pyrazol(3,4- d )pyramide (PP2) and the phosphatidylinositol 3-kinase inhibitor LY 294002. Tyrosine phosphorylation of tau and MAP2c was concomitant with an increase in the tyrosine phosphorylation and subsequent putative activation of the non-receptor kinase, focal adhesion kinase (FAK). Immunoprecipitation of Fyn, a member of the Src family, from Aβ 25–35 -treated neurons showed an increased association of Fyn with FAK. Aβ treatment of cells also stimulated the sustained activation of extracellular regulated kinase-2, which was blocked by addition of PP2 and LY 294002, suggesting that FAK/Fyn/PI3-kinase association is upstream of mitogen-activated protein (MAP) kinase signaling in Aβ-treated neurons. This cascade of signaling events contains the earliest biochemical changes in neurons to be described in response to Aβ exposure and may be critical for subsequent neurodegenerative changes." @default.
• W1841303832 created "2016-06-24" @default.
• W1841303832 creator A5006993794 @default.
• W1841303832 creator A5007919150 @default.
• W1841303832 creator A5014856664 @default.
• W1841303832 creator A5021794854 @default.
• W1841303832 creator A5029067531 @default.
• W1841303832 creator A5039123896 @default.
• W1841303832 creator A5042096844 @default.
• W1841303832 creator A5045468904 @default.
• W1841303832 creator A5049509802 @default.
• W1841303832 creator A5085226790 @default.
• W1841303832 creator A5085630029 @default.
• W1841303832 date "2002-01-01" @default.
• W1841303832 modified "2023-10-18" @default.
• W1841303832 title "Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases" @default.
• W1841303832 cites W1519184577 @default.
• W1841303832 cites W1530865401 @default.
• W1841303832 cites W1554056120 @default.
• W1841303832 cites W1569078050 @default.
• W1841303832 cites W1575367484 @default.
• W1841303832 cites W1577397450 @default.
• W1841303832 cites W1608295855 @default.
• W1841303832 cites W1704204892 @default.
• W1841303832 cites W1785533687 @default.
• W1841303832 cites W1899552864 @default.
• W1841303832 cites W1963687683 @default.
• W1841303832 cites W1963754791 @default.
• W1841303832 cites W1965232330 @default.
• W1841303832 cites W1969063564 @default.
• W1841303832 cites W1970300315 @default.
• W1841303832 cites W1973774127 @default.
• W1841303832 cites W1974068776 @default.
• W1841303832 cites W1982947429 @default.
• W1841303832 cites W1984482388 @default.
• W1841303832 cites W1985090720 @default.
• W1841303832 cites W1988560523 @default.
• W1841303832 cites W1992274803 @default.
• W1841303832 cites W1996917933 @default.
• W1841303832 cites W2001432072 @default.
• W1841303832 cites W2006520473 @default.
• W1841303832 cites W2008354106 @default.
• W1841303832 cites W2009688542 @default.
• W1841303832 cites W2012799785 @default.
• W1841303832 cites W2013052548 @default.
• W1841303832 cites W2016683201 @default.
• W1841303832 cites W2019834014 @default.
• W1841303832 cites W2025391374 @default.
• W1841303832 cites W2033825402 @default.
• W1841303832 cites W2045012491 @default.
• W1841303832 cites W2046299498 @default.
• W1841303832 cites W2050687441 @default.
• W1841303832 cites W2052794643 @default.
• W1841303832 cites W2058085247 @default.
• W1841303832 cites W2062101237 @default.
• W1841303832 cites W2066896236 @default.
• W1841303832 cites W2073660848 @default.
• W1841303832 cites W2076649773 @default.
• W1841303832 cites W2079115900 @default.
• W1841303832 cites W2081998222 @default.
• W1841303832 cites W2082429191 @default.
• W1841303832 cites W2082963940 @default.
• W1841303832 cites W2084461848 @default.
• W1841303832 cites W2088497083 @default.
• W1841303832 cites W2090501101 @default.
• W1841303832 cites W2094173028 @default.
• W1841303832 cites W2095750495 @default.
• W1841303832 cites W2101077392 @default.
• W1841303832 cites W2104962877 @default.
• W1841303832 cites W2108549874 @default.
• W1841303832 cites W2121366141 @default.
• W1841303832 cites W2128635872 @default.
• W1841303832 cites W2137985055 @default.
• W1841303832 cites W2138523588 @default.
• W1841303832 cites W2142579731 @default.
• W1841303832 cites W2148560401 @default.
• W1841303832 cites W2153658878 @default.
• W1841303832 cites W2154721456 @default.
• W1841303832 cites W2158676848 @default.
• W1841303832 cites W2158748165 @default.
• W1841303832 cites W2164296549 @default.
• W1841303832 cites W2165021720 @default.
• W1841303832 cites W2313081412 @default.
• W1841303832 cites W2341558723 @default.
• W1841303832 cites W4246732600 @default.
• W1841303832 cites W4249092084 @default.
• W1841303832 cites W4293247451 @default.
• W1841303832 cites W4293775696 @default.
• W1841303832 doi "https://doi.org/10.1523/jneurosci.22-01-00010.2002" @default.
• W1841303832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757621" @default.
• W1841303832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11756483" @default.
• W1841303832 hasPublicationYear "2002" @default.
• W1841303832 type Work @default.
• W1841303832 sameAs 1841303832 @default.
• W1841303832 citedByCount "209" @default.
• W1841303832 countsByYear W18413038322012 @default.
• W1841303832 countsByYear W18413038322013 @default.
• W1841303832 countsByYear W18413038322014 @default.

• next