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• W1842123981 endingPage "4725" @default.
• W1842123981 startingPage "4717" @default.
• W1842123981 abstract "The primary structures of interferon (IFN)-induced guanylate-binding proteins (GBPs) were deduced from cloned human and murine cDNAs. These proteins contained only two of the three sequence motifs typically found in GTP/GDP-binding proteins. The N(T)KXD motif, which is believed to confer guanine specificity in other nucleotide-binding proteins, was absent. Nevertheless, the IFN-induced GBPs exhibited a high degree of selectivity for binding to agarose-immobilized guanine nucleotides. An interesting feature of IFN-induced GBPs is that they strongly bound to GMP agarose in addition to GDP and GTP agaroses but failed to bind to ATP agarose and all other nucleotide agaroses tested. Both GTP and GMP, but not ATP, competed for binding of murine GBP-1 to agarose-immobilized GMP. The IFN-induced GBPs thus define a distinct novel family of proteins with GTP-binding activity. We further demonstrate that human and murine cells contain at least two genes encoding IFN-induced GBPs. The cloned murine cDNA codes for GBP-1, an IFN-induced protein previously shown to be absent from mice of Gbp-1b genotype." @default.
• W1842123981 created "2016-06-24" @default.
• W1842123981 creator A5014070689 @default.
• W1842123981 creator A5016636623 @default.
• W1842123981 creator A5025497504 @default.
• W1842123981 date "1991-09-01" @default.
• W1842123981 modified "2023-10-18" @default.
• W1842123981 title "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP." @default.
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• W1842123981 doi "https://doi.org/10.1128/mcb.11.9.4717" @default.
• W1842123981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/361367" @default.
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• W1842123981 hasPublicationYear "1991" @default.
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