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- W1842188085 abstract "Abstract Genetic disorders are usually considered to be caused by harmful gene mutations, as well as by chromosomal aberrations, including small insertions, duplications and/or deletions. However, as infertile individuals often arise among the offspring of crosses between two fertile mouse strains, we postulate that a certain combination of ‘normal’ genes with neither gene mutations nor chromosomal aberrations can cause such serious phenotypic alterations as reproductive dysfunction. In this study, we show evidence that a combination of multiple normal genes from two different normal mouse strains manifests a wide range of male reproductive dysfunctions, from benign changes to complete infertility. These abnormal phenotypes are thought to have occurred by epistatic interactions of alleles." @default.
- W1842188085 created "2016-06-24" @default.
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- W1842188085 date "2012-11-26" @default.
- W1842188085 modified "2023-10-17" @default.
- W1842188085 title "Spermatogenic defects in F2 mice between normal mouse strains C3H and C57BL/6 without mutation" @default.
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- W1842188085 doi "https://doi.org/10.1111/j.1741-4520.2012.00379.x" @default.
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