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• W184233225 abstract "Although the digitalis glycosides are generally the most valuable drugs available for the treatment of heart failure, a relatively high incidence of toxic manifestations has accompanied the widespread employment and beneficial positive contractile action of these agents. Thus, digitalis intoxication appears to be among the most common adverse drug reactions and has been reported to occur in as many as 20% of patients receiving the glycosides (Stone and Fisch, 1969; Gotsman and Schrire, 1966; Gilfrich and Scholmerich, 1975; Doering et al., 1977a, b; Larbig et al., 1978). Although the most common and earliest side effects are related to the gastrointestinal tract owing to glycoside action on the central nervous system rather than local gastric irritation, disorders of cardiac rhythm are the first manifestations in one-third of patients. It has been estimated that arrhythmias and conduction disturbances are provoked in up to 80% of patients in whom toxic effects are observed (Chou, 1969; Fisch and Knoebel, 1970). Both retrospective and prospective clinical studies of digitalis overdose have demonstrated considerable variability of cardiac and extracardiac manifestations without predictability concerning the rhythm disorder produced, even with administration of the identical glycoside preparation in the same patient (Church et al., 1962; Dreifus et al., 1963). Hence, each of the digitalis glycosides is equally capable of producing the signs and symptoms of digitalis toxicity, and no special advantage is obtained with some preparations in regard to earlier onset of less hazardous extracardiac reactions or reduced incidence of arrhythmias." @default.
• W184233225 created "2016-06-24" @default.
• W184233225 creator A5018832071 @default.
• W184233225 creator A5043073307 @default.
• W184233225 date "1981-01-01" @default.
• W184233225 modified "2023-09-27" @default.
• W184233225 title "Side Effects and Intoxication of Cardiac Glycosides: Manifestations and Treatment" @default.
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• W184233225 doi "https://doi.org/10.1007/978-3-642-68166-0_13" @default.
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