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- W1842412829 abstract "CCl4 injury to the liver interfered with the normal metabolism of benzo[a]pyrene, particularly in relation to the derivatives of 3-hydroxybenzo[a]pyrene. The primary, though not exclusive, alteration in function was related to the reduction of one double bond and the conjugation of metabolites with glucuronic acid. Clearance of benzo[a]pyrene from sites of administration and the circulatory system was both delayed and diminished in the injured liver. Recovery of administered isotope in the form of carbon-labeled benzo[a]pyrene was reduced. The sites of localization of benzo[a]pyrene were undetermined; however, the organs concerned with metabolism and excretion revealed no abnormal concentration. Decreased flow of bile was eliminated as the primary explanation for our findings since abnormal metabolic products persisted even when bile flow was artificially maintained at a normal rate. Rats genetically deficient in glucuronic acid transferase yielded a pattern of metabolites similar in certain aspects to that observed after liver injury. Histologically, liver injury produced was typical of CCl4 intoxication. Pathologic and physiologic recovery was complete in 5 to 6 days with normal morphologic and metabolic findings. In bioassay studies an enhanced tumorigenic response resulted in mice given subcutaneous injections of CCl4 and benzo[a]pyrene in comparison to mice receiving benzo[a]pyrene alone subcutaneously." @default.
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- W1842412829 date "1962-03-01" @default.
- W1842412829 modified "2023-09-27" @default.
- W1842412829 title "Effect of Carbon Tetrachloride Intoxication on Metabolism of Benzo[<italic>a</italic>]pyrene in Rats and Mice<xref ref-type=fn rid=fn1>2</xref>" @default.
- W1842412829 doi "https://doi.org/10.1093/jnci/28.3.725" @default.
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