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- W184261774 abstract "The host response to fungal infection is the result of a complex interaction between the pathogen and the host's innate and adaptive immune system. Cell-mediated immunity is widely considered to be critical for the successful outcome of fungal infections. However, in recent years numerous studies have established that certain antibodies may play an important role in host immunoprotection against pathogenic fungi, through interaction with different cellular targets, such as mannans, heat shock proteins, capsular polysaccharides, surface proteins, and yeast killer toxin receptors, with mechanisms of action sometimes still undefined. This review summarizes the latest findings on the role of different types of antibodies in the antifungal defense against infections caused by epidemiologically important fungi, such as Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and others. New perspectives of antibody-mediated therapy, based on the availability of monoclonal and recombinant antibodies as well as genetically engineered antibody fragments of defined specificity, will be also envisaged and discussed." @default.
- W184261774 created "2016-06-24" @default.
- W184261774 creator A5009136557 @default.
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- W184261774 date "2005-10-01" @default.
- W184261774 modified "2023-09-23" @default.
- W184261774 title "Antibody-mediated protective immunity in fungal infections." @default.
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- W184261774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16386014" @default.
- W184261774 hasPublicationYear "2005" @default.
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