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• W1842692445 abstract "No AccessJournal of Urology1 Jul 1991Sympathetic Inhibition of Papaverine Induced Erection W. Diederichs, C.G. Stief, T.F. Lue, and E.A. Tanagho W. DiederichsW. Diederichs More articles by this author , C.G. StiefC.G. Stief More articles by this author , T.F. LueT.F. Lue More articles by this author , and E.A. TanaghoE.A. Tanagho More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37751-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We studied the effect of neurostimulation of the lumbar sympathetic trunks on papaverine-Induced penile erection in dogs and monkeys. The mean of 124cm. H20 intracavernous pressure after papaverine injection was reduced under sympathetic trunk stimulation to 40.6cm. H20 within a mean of 39sec. In addition the flow of the internal pudendal artery was reduced indicating a decrease of the Inflow to the penis. After the sympathetic stimulation was terminated, the Intracavernous pressure increased again to the same level as before. This pressure recovery time was delayed after several sympathetic stimulations from 134sec. (5min. after papaverine injection) to at least 362sec. (45minutes after papaverine injection). Stimulation of the Inferior hypogastric plexus had no effect on the intracavernous pressure. The neurostimulation range (3–4V; 20Hz) was most effective in reducing the papaverine action on penile smooth muscles. The effect of sympathetic trunk stimulation seems to antagonize the relaxing action of papaverine on the cavernous smooth muscles and the cavernous arterioles. Our results imply that high sympathetic tone In some patients with psychogenic Impotence may explain their poor response to intracavernous Injection of papaverine. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySimonsen U, Prieto D, Hernandez M, de Tejada I and Garcia-Sacristan A (2018) Prejunctional alpha sub 2-Adrenoceptors Inhibit Nitrergic Neurotransmission in Horse Penile Resistance ArteriesJournal of Urology, VOL. 157, NO. 6, (2356-2360), Online publication date: 1-Jun-1997.Cormio L, Nisen H, Selvaggi F and Ruutu M (2018) A Positive Pharmacological Erection Test Does not Rule Out Arteriogenic Erectile DysfunctionJournal of Urology, VOL. 156, NO. 5, (1628-1630), Online publication date: 1-Nov-1996.Stief C, Höppner H, Sauerwein D and Jonas U (2018) Single Potential Analysis of Cavernous Electrical Activity in Spinal Cord Injury patientsJournal of Urology, VOL. 151, NO. 2, (367-372), Online publication date: 1-Feb-1994.Giuliano F, Bernabe J, Jardin A and Paul Rousseau J (2018) Antierectile Role of the Sympathetic Nervous System in RatsJournal of Urology, VOL. 150, NO. 2 Part 1, (519-524), Online publication date: 1-Aug-1993.Djamilian M, Stief C, Hartmann U and Jonas U (2018) Predictive Value of Real-Time Rigiscan Monitoring for the Etiology of Organogenic ImpotenceJournal of Urology, VOL. 149, NO. 5 Part 2, (1269-1271), Online publication date: 1-May-1993. Volume 146Issue 1July 1991Page: 195-198 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordspenispapaverinepenile erectionMetricsAuthor Information W. Diederichs More articles by this author C.G. Stief More articles by this author T.F. Lue More articles by this author E.A. Tanagho More articles by this author Expand All Advertisement Loading ..." @default.
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• W1842692445 title "Sympathetic Inhibition of Papaverine Induced Erection" @default.
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