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• W1842778530 endingPage "e0141128" @default.
• W1842778530 startingPage "e0141128" @default.
• W1842778530 abstract "Inorganic phosphate (Pi) has central roles in metabolism, cell signaling and energy conversion. The distribution of Pi to each cell and cellular compartment of an animal must be tightly coordinated with its dietary supply and with the varied metabolic demands of individual cells. An analytical method for monitoring Pi dynamics with spatial and temporal resolution is therefore needed to gain a comprehensive understanding of mechanisms governing the transport and recycling of this essential nutrient. Here we demonstrate the utility of a genetically encoded FRET-based Pi sensor to assess cellular Pi levels in the nematode Caenorhabditis elegans. The sensor was expressed in different cells and tissues of the animal, including head neurons, tail neurons, pharyngeal muscle, and the intestine. Cytosolic Pi concentrations were monitored using ratiometric imaging. Injection of phosphate buffer into intestinal cells confirmed that the sensor was responsive to changes in Pi concentration in vivo. Live Pi imaging revealed cell-specific and developmental stage-specific differences in cytosolic Pi concentrations. In addition, cellular Pi levels were perturbed by food deprivation and by exposure to the respiratory inhibitor cyanide. These results suggest that Pi concentration is a sensitive indicator of metabolic status. Moreover, we propose that live Pi imaging in C. elegans is a powerful approach to discern mechanisms that govern Pi distribution in individual cells and throughout an animal." @default.
• W1842778530 created "2016-06-24" @default.
• W1842778530 creator A5030043827 @default.
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• W1842778530 date "2015-10-20" @default.
• W1842778530 modified "2023-10-16" @default.
• W1842778530 title "Imaging Cellular Inorganic Phosphate in Caenorhabditis elegans Using a Genetically Encoded FRET-Based Biosensor" @default.
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• W1842778530 doi "https://doi.org/10.1371/journal.pone.0141128" @default.
• W1842778530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4615621" @default.
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• W1842778530 hasPublicationYear "2015" @default.
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