Matches in SemOpenAlex for { <https://semopenalex.org/work/W184286843> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W184286843 abstract "The distribution and metabolism of the toxic environmental pollutant, 2,3,7,8-tetrachlorodibenzofuran (TCDF) was studied after p.o. and i.v. administration of 14C-TCDF to male Hartley guinea pigs (0.02 μmoles/kg) and Fischer 344 rats (0.1 and 1.0 μmoles/kg), and after i.v. administration to male Rhesus monkeys (0.1 μmoles/kg). TCDF was readily and nearly completely absorbed from the gastrointestinal tract by rats and guinea pigs. Distribution was not affected by route of exposure. In each species examined, the liver was the initial major depot for TCDF, with lesser amounts in adipose tissue, skin and muscle, respectively. Rats, and to a lesser extent, monkeys, were able to metabolize and excrete TCDF-derived radioactivity. Guinea pigs were not able to metabolize TCDF and excreted only 6.5% of the dose in the feces as parent compound within 9 days. Toxicity was irreversible in the guinea pig and resulted in progressive weight loss and death. In contrast, the rat excreted metabolites of TCDF in the feces, which accounted for greater than 50% of the dose within 2 days, and recovered from symptoms of intoxication within one week. Rhesus monkeys showed an intermediate ability to metabolize TCDF and intermediate sensitivity to TCDF intoxication. The whole-body half-life of TCDF in guinea pigs, monkeys, and rats was estimated to be >20, 8, and <2 days, respectively. These studies indicate that metabolism of TCDF is a detoxification mechanism and that species which are able to metabolize and clear TCDF are more resistant to its acute toxicity." @default.
- W184286843 created "2016-06-24" @default.
- W184286843 creator A5023792841 @default.
- W184286843 creator A5038924107 @default.
- W184286843 creator A5091509523 @default.
- W184286843 date "1982-01-01" @default.
- W184286843 modified "2023-10-11" @default.
- W184286843 title "DISPOSITION OF 2,3,7,8-TETRACHLORODIBENZOFURAN IN GUINEA PIGS, RATS, AND MONKEYS" @default.
- W184286843 cites W1986598955 @default.
- W184286843 cites W2005520075 @default.
- W184286843 cites W2006844638 @default.
- W184286843 cites W2036422456 @default.
- W184286843 cites W2050136099 @default.
- W184286843 cites W2059376673 @default.
- W184286843 cites W2059643908 @default.
- W184286843 cites W2061427284 @default.
- W184286843 cites W2170250045 @default.
- W184286843 doi "https://doi.org/10.1016/b978-0-08-026256-7.50032-5" @default.
- W184286843 hasPublicationYear "1982" @default.
- W184286843 type Work @default.
- W184286843 sameAs 184286843 @default.
- W184286843 citedByCount "7" @default.
- W184286843 countsByYear W1842868432019 @default.
- W184286843 crossrefType "book-chapter" @default.
- W184286843 hasAuthorship W184286843A5023792841 @default.
- W184286843 hasAuthorship W184286843A5038924107 @default.
- W184286843 hasAuthorship W184286843A5091509523 @default.
- W184286843 hasConcept C126322002 @default.
- W184286843 hasConcept C134018914 @default.
- W184286843 hasConcept C151730666 @default.
- W184286843 hasConcept C171089720 @default.
- W184286843 hasConcept C185592680 @default.
- W184286843 hasConcept C195289149 @default.
- W184286843 hasConcept C2777056448 @default.
- W184286843 hasConcept C2778815084 @default.
- W184286843 hasConcept C2780512811 @default.
- W184286843 hasConcept C29730261 @default.
- W184286843 hasConcept C55493867 @default.
- W184286843 hasConcept C61716771 @default.
- W184286843 hasConcept C62231903 @default.
- W184286843 hasConcept C71924100 @default.
- W184286843 hasConcept C86803240 @default.
- W184286843 hasConceptScore W184286843C126322002 @default.
- W184286843 hasConceptScore W184286843C134018914 @default.
- W184286843 hasConceptScore W184286843C151730666 @default.
- W184286843 hasConceptScore W184286843C171089720 @default.
- W184286843 hasConceptScore W184286843C185592680 @default.
- W184286843 hasConceptScore W184286843C195289149 @default.
- W184286843 hasConceptScore W184286843C2777056448 @default.
- W184286843 hasConceptScore W184286843C2778815084 @default.
- W184286843 hasConceptScore W184286843C2780512811 @default.
- W184286843 hasConceptScore W184286843C29730261 @default.
- W184286843 hasConceptScore W184286843C55493867 @default.
- W184286843 hasConceptScore W184286843C61716771 @default.
- W184286843 hasConceptScore W184286843C62231903 @default.
- W184286843 hasConceptScore W184286843C71924100 @default.
- W184286843 hasConceptScore W184286843C86803240 @default.
- W184286843 hasLocation W1842868431 @default.
- W184286843 hasOpenAccess W184286843 @default.
- W184286843 hasPrimaryLocation W1842868431 @default.
- W184286843 hasRelatedWork W1847225907 @default.
- W184286843 hasRelatedWork W1869429806 @default.
- W184286843 hasRelatedWork W1972099520 @default.
- W184286843 hasRelatedWork W1982769345 @default.
- W184286843 hasRelatedWork W2000784355 @default.
- W184286843 hasRelatedWork W2011568519 @default.
- W184286843 hasRelatedWork W2029645215 @default.
- W184286843 hasRelatedWork W2032542284 @default.
- W184286843 hasRelatedWork W2050744405 @default.
- W184286843 hasRelatedWork W2055932133 @default.
- W184286843 hasRelatedWork W2060792860 @default.
- W184286843 hasRelatedWork W2074569726 @default.
- W184286843 hasRelatedWork W2148509162 @default.
- W184286843 hasRelatedWork W2152619272 @default.
- W184286843 hasRelatedWork W2333095540 @default.
- W184286843 hasRelatedWork W2404324216 @default.
- W184286843 hasRelatedWork W2411477349 @default.
- W184286843 hasRelatedWork W2414978216 @default.
- W184286843 hasRelatedWork W275798727 @default.
- W184286843 hasRelatedWork W59063062 @default.
- W184286843 isParatext "false" @default.
- W184286843 isRetracted "false" @default.
- W184286843 magId "184286843" @default.
- W184286843 workType "book-chapter" @default.