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- W184293581 abstract "Publisher Summary This chapter focuses on advances made to date in an effort to link genetic individual variations and reward processing as a possible basis for addictive behaviors. Dopaminergic neurotransmission is widely recognized to be critical to the neurobiology of reward, motivation, and addiction. Genetic variation in several key dopaminergic subsystems, presumably resulting in altered central dopaminergic tone and neurotransmission, has been associated with various aspects of personality and temperament as well as susceptibility to addiction. However, enthusiasm for the potential of such genetic variation to addiction has been tempered by inconsistent results and failed attempts to replicate specific associations. Such inconsistency may reflect the underlying biological nature of the relationship between allelic variants in dopamine-related genes, each of presumably slight effect, and observable behaviors that as a rule reproduce complex functional interactions. Thus, functional polymorphisms in dopamine-related genes might have marked influence upon the functionality of these underlying neural systems and intermediate their final effect on behavior." @default.
- W184293581 created "2016-06-24" @default.
- W184293581 creator A5033792391 @default.
- W184293581 creator A5091144031 @default.
- W184293581 date "2009-01-01" @default.
- W184293581 modified "2023-10-18" @default.
- W184293581 title "The genetic basis of individual differences in reward processing and the link to addictive behavior" @default.
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- W184293581 doi "https://doi.org/10.1016/b978-0-12-374620-7.00016-9" @default.