Matches in SemOpenAlex for { <https://semopenalex.org/work/W1842976670> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1842976670 endingPage "74" @default.
- W1842976670 startingPage "969" @default.
- W1842976670 abstract "The behavioral effects of MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo(a,d)cyclohepten-5,10-imin e], a proposed noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were compared to those of phencyclidine (PCP). In pigeons, MK-801 produced PCP-like catalepsy (i.e., loss of righting without eye closure and without muscle relaxation) and PCP-like discriminative stimulus effects. In rats, MK-801 produced PCP-like behavior (i.e., locomotion, sniffing, swaying and falling). In rhesus monkeys, like PCP, MK-801 produced 1) ketamine-like discriminative stimulus effects, 2) positive reinforcing effects and 3) ketamine-like anesthetic effects (i.e., anesthesia without eye closure and without respiratory depression, but with profuse salivation and with some muscle relaxation). Thus, MK-801 produced PCP-like behavioral effects in each species and with each procedure. MK-801 was 2 to 10 times more potent than PCP, depending on the effect measured and the species tested. Because MK-801 has been shown to have NMDA-antagonist properties, the findings of this study offer further support for the hypothesis that certain behavioral effects of PCP-like drugs may result from a reduction of neurotransmission at excitatory synapses utilizing NMDA-preferring receptors. The behavioral similarities between MK-801 and PCP make it relevant to evaluate PCP-like activity in clinical trials of MK-801." @default.
- W1842976670 created "2016-06-24" @default.
- W1842976670 creator A5033646990 @default.
- W1842976670 creator A5048828590 @default.
- W1842976670 creator A5080164174 @default.
- W1842976670 date "1988-06-01" @default.
- W1842976670 modified "2023-09-29" @default.
- W1842976670 title "MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys." @default.
- W1842976670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2838610" @default.
- W1842976670 hasPublicationYear "1988" @default.
- W1842976670 type Work @default.
- W1842976670 sameAs 1842976670 @default.
- W1842976670 citedByCount "107" @default.
- W1842976670 countsByYear W18429766702012 @default.
- W1842976670 countsByYear W18429766702014 @default.
- W1842976670 countsByYear W18429766702015 @default.
- W1842976670 countsByYear W18429766702016 @default.
- W1842976670 countsByYear W18429766702022 @default.
- W1842976670 countsByYear W18429766702023 @default.
- W1842976670 crossrefType "journal-article" @default.
- W1842976670 hasAuthorship W1842976670A5033646990 @default.
- W1842976670 hasAuthorship W1842976670A5048828590 @default.
- W1842976670 hasAuthorship W1842976670A5080164174 @default.
- W1842976670 hasConcept C112592302 @default.
- W1842976670 hasConcept C124315065 @default.
- W1842976670 hasConcept C131722271 @default.
- W1842976670 hasConcept C15744967 @default.
- W1842976670 hasConcept C169760540 @default.
- W1842976670 hasConcept C170493617 @default.
- W1842976670 hasConcept C17077164 @default.
- W1842976670 hasConcept C185592680 @default.
- W1842976670 hasConcept C200170125 @default.
- W1842976670 hasConcept C2776885963 @default.
- W1842976670 hasConcept C2777836312 @default.
- W1842976670 hasConcept C2778851735 @default.
- W1842976670 hasConcept C2780795376 @default.
- W1842976670 hasConcept C42219234 @default.
- W1842976670 hasConcept C55493867 @default.
- W1842976670 hasConcept C67018056 @default.
- W1842976670 hasConcept C71924100 @default.
- W1842976670 hasConcept C98274493 @default.
- W1842976670 hasConceptScore W1842976670C112592302 @default.
- W1842976670 hasConceptScore W1842976670C124315065 @default.
- W1842976670 hasConceptScore W1842976670C131722271 @default.
- W1842976670 hasConceptScore W1842976670C15744967 @default.
- W1842976670 hasConceptScore W1842976670C169760540 @default.
- W1842976670 hasConceptScore W1842976670C170493617 @default.
- W1842976670 hasConceptScore W1842976670C17077164 @default.
- W1842976670 hasConceptScore W1842976670C185592680 @default.
- W1842976670 hasConceptScore W1842976670C200170125 @default.
- W1842976670 hasConceptScore W1842976670C2776885963 @default.
- W1842976670 hasConceptScore W1842976670C2777836312 @default.
- W1842976670 hasConceptScore W1842976670C2778851735 @default.
- W1842976670 hasConceptScore W1842976670C2780795376 @default.
- W1842976670 hasConceptScore W1842976670C42219234 @default.
- W1842976670 hasConceptScore W1842976670C55493867 @default.
- W1842976670 hasConceptScore W1842976670C67018056 @default.
- W1842976670 hasConceptScore W1842976670C71924100 @default.
- W1842976670 hasConceptScore W1842976670C98274493 @default.
- W1842976670 hasIssue "3" @default.
- W1842976670 hasLocation W18429766701 @default.
- W1842976670 hasOpenAccess W1842976670 @default.
- W1842976670 hasPrimaryLocation W18429766701 @default.
- W1842976670 hasRelatedWork W1842976670 @default.
- W1842976670 hasRelatedWork W1870944445 @default.
- W1842976670 hasRelatedWork W1940282268 @default.
- W1842976670 hasRelatedWork W1974609764 @default.
- W1842976670 hasRelatedWork W2014693564 @default.
- W1842976670 hasRelatedWork W2016690333 @default.
- W1842976670 hasRelatedWork W2028568597 @default.
- W1842976670 hasRelatedWork W2053852097 @default.
- W1842976670 hasRelatedWork W2093803465 @default.
- W1842976670 hasRelatedWork W2395612880 @default.
- W1842976670 hasVolume "245" @default.
- W1842976670 isParatext "false" @default.
- W1842976670 isRetracted "false" @default.
- W1842976670 magId "1842976670" @default.
- W1842976670 workType "article" @default.