Matches in SemOpenAlex for { <https://semopenalex.org/work/W1843007579> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1843007579 endingPage "142" @default.
- W1843007579 startingPage "135" @default.
- W1843007579 abstract "1. Two hypotheses to account for general catabolite repression of the lactose enzymes in Escherichia coli were tested: the dilution model of Palmer & Moses (1967), and the specific catabolite repressor model of Loomis & Magasanik (1965, 1967). 2. The dilution model predicts that in mutants lacking the i–o regulation system the differential rate of β-galactosidase synthesis should increase when amino acid-synthesizing enzymes are repressed by the presence of amino acids in the medium. It also predicts that with such mutants the total absence of Pi from the medium should not result in the complete cessation of β-galactosidase synthesis that is observed with wild-type cells. 3. Neither prediction was confirmed experimentally, and it is concluded that this model cannot explain catabolite repression. 4. The specific repressor hypothesis depends on the properties of a strain of E. coli carrying the CR− mutation. It requires both that cells of this genotype should be totally resistant to general catabolite repression and that this resistance should be specific for the lactose enzymes. 5. In fact the synthesis of β-galactosidase by CR− cells, though showing resistance to catabolite repression by growth on glucose, was found to be repressed in several other circumstances. 6. Two other inducible enzymes, l-tryptophanase and d-serine deaminase, also showed resistance to repression by glucose in CR− cells. 7. It is concluded that this model, too, does not account for general catabolite repression. 8. Strains carrying deletions at either end of the lactose operon that extend into the structural genes of the operon continue to exhibit catabolite repression. 9. These experiments appear to eliminate the possibility that catabolite repression operates at the level of DNA transcription, and suggest that repression affects instead the translation of messenger RNA into protein." @default.
- W1843007579 created "2016-06-24" @default.
- W1843007579 creator A5039383019 @default.
- W1843007579 creator A5080639770 @default.
- W1843007579 date "1968-11-01" @default.
- W1843007579 modified "2023-10-16" @default.
- W1843007579 title "Catabolite repression in Escherichia coli. A study of two hypotheses" @default.
- W1843007579 cites W1523216517 @default.
- W1843007579 cites W1716587387 @default.
- W1843007579 cites W1775749144 @default.
- W1843007579 cites W1926561214 @default.
- W1843007579 cites W1936398220 @default.
- W1843007579 cites W1987404887 @default.
- W1843007579 cites W2023628640 @default.
- W1843007579 cites W2032619610 @default.
- W1843007579 cites W2091697103 @default.
- W1843007579 cites W2178141876 @default.
- W1843007579 cites W2314067827 @default.
- W1843007579 cites W2335730326 @default.
- W1843007579 cites W2341587500 @default.
- W1843007579 cites W2404673886 @default.
- W1843007579 cites W291463256 @default.
- W1843007579 cites W46105026 @default.
- W1843007579 doi "https://doi.org/10.1042/bj1100135" @default.
- W1843007579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1187118" @default.
- W1843007579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4881142" @default.
- W1843007579 hasPublicationYear "1968" @default.
- W1843007579 type Work @default.
- W1843007579 sameAs 1843007579 @default.
- W1843007579 citedByCount "12" @default.
- W1843007579 countsByYear W18430075792021 @default.
- W1843007579 crossrefType "journal-article" @default.
- W1843007579 hasAuthorship W1843007579A5039383019 @default.
- W1843007579 hasAuthorship W1843007579A5080639770 @default.
- W1843007579 hasBestOaLocation W18430075792 @default.
- W1843007579 hasConcept C100544194 @default.
- W1843007579 hasConcept C104317684 @default.
- W1843007579 hasConcept C143065580 @default.
- W1843007579 hasConcept C150194340 @default.
- W1843007579 hasConcept C158448853 @default.
- W1843007579 hasConcept C167431671 @default.
- W1843007579 hasConcept C170344550 @default.
- W1843007579 hasConcept C181199279 @default.
- W1843007579 hasConcept C186310378 @default.
- W1843007579 hasConcept C203075996 @default.
- W1843007579 hasConcept C2778724459 @default.
- W1843007579 hasConcept C2910736867 @default.
- W1843007579 hasConcept C43053761 @default.
- W1843007579 hasConcept C547475151 @default.
- W1843007579 hasConcept C55493867 @default.
- W1843007579 hasConcept C83941689 @default.
- W1843007579 hasConcept C86803240 @default.
- W1843007579 hasConceptScore W1843007579C100544194 @default.
- W1843007579 hasConceptScore W1843007579C104317684 @default.
- W1843007579 hasConceptScore W1843007579C143065580 @default.
- W1843007579 hasConceptScore W1843007579C150194340 @default.
- W1843007579 hasConceptScore W1843007579C158448853 @default.
- W1843007579 hasConceptScore W1843007579C167431671 @default.
- W1843007579 hasConceptScore W1843007579C170344550 @default.
- W1843007579 hasConceptScore W1843007579C181199279 @default.
- W1843007579 hasConceptScore W1843007579C186310378 @default.
- W1843007579 hasConceptScore W1843007579C203075996 @default.
- W1843007579 hasConceptScore W1843007579C2778724459 @default.
- W1843007579 hasConceptScore W1843007579C2910736867 @default.
- W1843007579 hasConceptScore W1843007579C43053761 @default.
- W1843007579 hasConceptScore W1843007579C547475151 @default.
- W1843007579 hasConceptScore W1843007579C55493867 @default.
- W1843007579 hasConceptScore W1843007579C83941689 @default.
- W1843007579 hasConceptScore W1843007579C86803240 @default.
- W1843007579 hasIssue "1" @default.
- W1843007579 hasLocation W18430075791 @default.
- W1843007579 hasLocation W18430075792 @default.
- W1843007579 hasLocation W18430075793 @default.
- W1843007579 hasLocation W18430075794 @default.
- W1843007579 hasOpenAccess W1843007579 @default.
- W1843007579 hasPrimaryLocation W18430075791 @default.
- W1843007579 hasRelatedWork W1484981399 @default.
- W1843007579 hasRelatedWork W1589078365 @default.
- W1843007579 hasRelatedWork W1629424959 @default.
- W1843007579 hasRelatedWork W1843007579 @default.
- W1843007579 hasRelatedWork W1865175546 @default.
- W1843007579 hasRelatedWork W1910000392 @default.
- W1843007579 hasRelatedWork W1923568694 @default.
- W1843007579 hasRelatedWork W2013447148 @default.
- W1843007579 hasRelatedWork W2123722285 @default.
- W1843007579 hasRelatedWork W2212710309 @default.
- W1843007579 hasVolume "110" @default.
- W1843007579 isParatext "false" @default.
- W1843007579 isRetracted "false" @default.
- W1843007579 magId "1843007579" @default.
- W1843007579 workType "article" @default.