FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1843014747> ?p ?o ?g. }

• W1843014747 endingPage "4427" @default.
• W1843014747 startingPage "4415" @default.
• W1843014747 abstract "Long non-coding RNAs (lncRNAs) transcribed extensively from the genome have been proposed to be key regulators of diverse biological processes. However, little is known about the role of lncRNAs in regulation of the cell-cycle G1/S checkpoint following DNA damage, a key step in the maintenance of genomic fidelity. Here we show that growth-arrested DNA damage-inducible gene 7 (gadd7), a DNA damage-inducible lncRNA, regulates the G1/S checkpoint in response to UV irradiation. Interestingly, UV-induced gadd7 directly binds to TAR DNA-binding protein (TDP-43) and interferes with the interaction between TDP-43 and cyclin-dependent kinase 6 (Cdk6) mRNA, resulting in Cdk6 mRNA degradation. These findings demonstrate a role for gadd7 in controlling cell-cycle progression and define a novel mechanism by which lncRNAs modulate mRNA expression at the post-transcriptional level by altering mRNA stability." @default.
• W1843014747 created "2016-06-24" @default.
• W1843014747 creator A5014963018 @default.
• W1843014747 creator A5031817044 @default.
• W1843014747 creator A5038851564 @default.
• W1843014747 creator A5070017335 @default.
• W1843014747 creator A5083607904 @default.
• W1843014747 date "2012-10-26" @default.
• W1843014747 modified "2023-10-02" @default.
• W1843014747 title "Long non-coding RNA<i>gadd7</i>interacts with TDP-43 and regulates<i>Cdk6</i>mRNA decay" @default.
• W1843014747 cites W1525431743 @default.
• W1843014747 cites W1570986231 @default.
• W1843014747 cites W1619082318 @default.
• W1843014747 cites W1966364136 @default.
• W1843014747 cites W1966682365 @default.
• W1843014747 cites W1967443709 @default.
• W1843014747 cites W1967932847 @default.
• W1843014747 cites W1974736226 @default.
• W1843014747 cites W1980913885 @default.
• W1843014747 cites W1984145170 @default.
• W1843014747 cites W1985955085 @default.
• W1843014747 cites W1992361112 @default.
• W1843014747 cites W1999746344 @default.
• W1843014747 cites W2008092626 @default.
• W1843014747 cites W2030047242 @default.
• W1843014747 cites W2039816251 @default.
• W1843014747 cites W2050099686 @default.
• W1843014747 cites W2060076138 @default.
• W1843014747 cites W2069139855 @default.
• W1843014747 cites W2075588816 @default.
• W1843014747 cites W2081420723 @default.
• W1843014747 cites W2087377443 @default.
• W1843014747 cites W2093836594 @default.
• W1843014747 cites W2095093723 @default.
• W1843014747 cites W2098516117 @default.
• W1843014747 cites W2101042581 @default.
• W1843014747 cites W2105292164 @default.
• W1843014747 cites W2105462242 @default.
• W1843014747 cites W2107754763 @default.
• W1843014747 cites W2112523914 @default.
• W1843014747 cites W2113722812 @default.
• W1843014747 cites W2114205900 @default.
• W1843014747 cites W2116086426 @default.
• W1843014747 cites W2116236561 @default.
• W1843014747 cites W2117047052 @default.
• W1843014747 cites W2121189598 @default.
• W1843014747 cites W2124050695 @default.
• W1843014747 cites W2127861463 @default.
• W1843014747 cites W2128817844 @default.
• W1843014747 cites W2132704668 @default.
• W1843014747 cites W2136949432 @default.
• W1843014747 cites W2137840425 @default.
• W1843014747 cites W2140798038 @default.
• W1843014747 cites W2146573461 @default.
• W1843014747 cites W2148253741 @default.
• W1843014747 cites W2153826038 @default.
• W1843014747 cites W2399166025 @default.
• W1843014747 doi "https://doi.org/10.1038/emboj.2012.292" @default.
• W1843014747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3512391" @default.
• W1843014747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23103768" @default.
• W1843014747 hasPublicationYear "2012" @default.
• W1843014747 type Work @default.
• W1843014747 sameAs 1843014747 @default.
• W1843014747 citedByCount "162" @default.
• W1843014747 countsByYear W18430147472012 @default.
• W1843014747 countsByYear W18430147472013 @default.
• W1843014747 countsByYear W18430147472014 @default.
• W1843014747 countsByYear W18430147472015 @default.
• W1843014747 countsByYear W18430147472016 @default.
• W1843014747 countsByYear W18430147472017 @default.
• W1843014747 countsByYear W18430147472018 @default.
• W1843014747 countsByYear W18430147472019 @default.
• W1843014747 countsByYear W18430147472020 @default.
• W1843014747 countsByYear W18430147472021 @default.
• W1843014747 countsByYear W18430147472022 @default.
• W1843014747 countsByYear W18430147472023 @default.
• W1843014747 crossrefType "journal-article" @default.
• W1843014747 hasAuthorship W1843014747A5014963018 @default.
• W1843014747 hasAuthorship W1843014747A5031817044 @default.
• W1843014747 hasAuthorship W1843014747A5038851564 @default.
• W1843014747 hasAuthorship W1843014747A5070017335 @default.
• W1843014747 hasAuthorship W1843014747A5083607904 @default.
• W1843014747 hasBestOaLocation W18430147472 @default.
• W1843014747 hasConcept C104317684 @default.
• W1843014747 hasConcept C105580179 @default.
• W1843014747 hasConcept C105696609 @default.
• W1843014747 hasConcept C124320809 @default.
• W1843014747 hasConcept C138885662 @default.
• W1843014747 hasConcept C143425029 @default.
• W1843014747 hasConcept C150194340 @default.
• W1843014747 hasConcept C153911025 @default.
• W1843014747 hasConcept C178169997 @default.
• W1843014747 hasConcept C179926584 @default.
• W1843014747 hasConcept C199649820 @default.
• W1843014747 hasConcept C29537977 @default.
• W1843014747 hasConcept C41895202 @default.
• W1843014747 hasConcept C54086632 @default.
• W1843014747 hasConcept C54355233 @default.

• next