Matches in SemOpenAlex for { <https://semopenalex.org/work/W184306073> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W184306073 endingPage "126" @default.
- W184306073 startingPage "123" @default.
- W184306073 abstract "We describe the use of a template for the recognition site of signal peptidase to give score predictions for cleavage at normal and aberrant sites in human and chicken preproalbumin. As expected, the highest score obtained for human preproalbumin was at the normal cleavage site between -7 Ser and -6 Arg. The mutation in preproalbumin Kaikoura (-2 Arg----Cys) introduced an aberrant cleavage site in the propeptide between the new -2 Cys and -1 Arg. Although the new site had a lower template score (6.88) than the normal site (9.99), it is cleaved in vivo about five times faster. The presence of minor proportions of des-Asp and des-Asp-Ala-albumin in normal human plasma was not found to correlate with possible aberrant signal peptidase cleavage. These truncated albumin species, therefore, appear to be generated through cleavage of mature albumin in circulation. Chicken preproalbumin had only one probably signal peptidase cleavage site, the one utilised in vivo. Template scores should be regarded as qualitative predictions rather than definitive quantitative indicators." @default.
- W184306073 created "2016-06-24" @default.
- W184306073 creator A5006756181 @default.
- W184306073 creator A5008620478 @default.
- W184306073 creator A5045078390 @default.
- W184306073 date "1991-08-01" @default.
- W184306073 modified "2023-09-23" @default.
- W184306073 title "Prediction of the site of signal peptidase cleavage in normal and variant human preproalbumin." @default.
- W184306073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1946330" @default.
- W184306073 hasPublicationYear "1991" @default.
- W184306073 type Work @default.
- W184306073 sameAs 184306073 @default.
- W184306073 citedByCount "1" @default.
- W184306073 crossrefType "journal-article" @default.
- W184306073 hasAuthorship W184306073A5006756181 @default.
- W184306073 hasAuthorship W184306073A5008620478 @default.
- W184306073 hasAuthorship W184306073A5045078390 @default.
- W184306073 hasConcept C104317684 @default.
- W184306073 hasConcept C10858879 @default.
- W184306073 hasConcept C151730666 @default.
- W184306073 hasConcept C153911025 @default.
- W184306073 hasConcept C167625842 @default.
- W184306073 hasConcept C175156509 @default.
- W184306073 hasConcept C207001950 @default.
- W184306073 hasConcept C2776125364 @default.
- W184306073 hasConcept C2779190341 @default.
- W184306073 hasConcept C43369102 @default.
- W184306073 hasConcept C54355233 @default.
- W184306073 hasConcept C55493867 @default.
- W184306073 hasConcept C86803240 @default.
- W184306073 hasConceptScore W184306073C104317684 @default.
- W184306073 hasConceptScore W184306073C10858879 @default.
- W184306073 hasConceptScore W184306073C151730666 @default.
- W184306073 hasConceptScore W184306073C153911025 @default.
- W184306073 hasConceptScore W184306073C167625842 @default.
- W184306073 hasConceptScore W184306073C175156509 @default.
- W184306073 hasConceptScore W184306073C207001950 @default.
- W184306073 hasConceptScore W184306073C2776125364 @default.
- W184306073 hasConceptScore W184306073C2779190341 @default.
- W184306073 hasConceptScore W184306073C43369102 @default.
- W184306073 hasConceptScore W184306073C54355233 @default.
- W184306073 hasConceptScore W184306073C55493867 @default.
- W184306073 hasConceptScore W184306073C86803240 @default.
- W184306073 hasIssue "2" @default.
- W184306073 hasOpenAccess W184306073 @default.
- W184306073 hasRelatedWork W1513011754 @default.
- W184306073 hasRelatedWork W1516951203 @default.
- W184306073 hasRelatedWork W1537103409 @default.
- W184306073 hasRelatedWork W1569857536 @default.
- W184306073 hasRelatedWork W1582717600 @default.
- W184306073 hasRelatedWork W1609819787 @default.
- W184306073 hasRelatedWork W1883375123 @default.
- W184306073 hasRelatedWork W1972307298 @default.
- W184306073 hasRelatedWork W1977588695 @default.
- W184306073 hasRelatedWork W2000007819 @default.
- W184306073 hasRelatedWork W2023906575 @default.
- W184306073 hasRelatedWork W2062888798 @default.
- W184306073 hasRelatedWork W2083956357 @default.
- W184306073 hasRelatedWork W2127624679 @default.
- W184306073 hasRelatedWork W2138511505 @default.
- W184306073 hasRelatedWork W2149270925 @default.
- W184306073 hasRelatedWork W2341864110 @default.
- W184306073 hasRelatedWork W309256353 @default.
- W184306073 hasRelatedWork W2825579482 @default.
- W184306073 hasRelatedWork W2864717376 @default.
- W184306073 hasVolume "4" @default.
- W184306073 isParatext "false" @default.
- W184306073 isRetracted "false" @default.
- W184306073 magId "184306073" @default.
- W184306073 workType "article" @default.