FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1843075121> ?p ?o ?g. }

• W1843075121 endingPage "543" @default.
• W1843075121 startingPage "531" @default.
• W1843075121 abstract "One of the goals of mechanosensitive channel (MSC) studies is to understand the underlying molecular and biophysical mechanisms of the mechano-gating process from force sensing to gate opening. We focus on the latter process and investigate the role of water in the bacterial MSC MscL, which is activated by membrane tension. We analyze the interplay between water and the gate-constituting amino acids, Leu19-Gly26, through molecular dynamics simulations. To highlight the role of water, specifically hydration of the gate, in MscL gating, we restrain lateral movements of the water molecules along the water-vapor interfaces at the top and bottom of the vapor bubble, plugging the closed gate. The gating behaviors in this model and the normal MscL model, in which water movements are unrestrained, are compared. In the normal model, increased membrane tension breaks the hydrogen bond between Leu19 and Val 23 of the inner helix, exposing the backbone carbonyl oxygen of Leu19 to the water-accessible lumen side of the gate. Associated with this activity, water comes to access the vapor region and stably interacts with the carbonyl oxygen to induce a dewetting to wetting transition that facilitates gate expansion toward channel opening. By contrast, in the water-restrained model, carbonyl oxygen is also exposed, but no further conformational changes occur at the gate. This suggests that gate opening relies on a conformational change initiated by wetting. The penetrated water weakens the hydrophobic interaction between neighboring transmembrane inner helices called the hydrophobic lock by wedging into the space between their interacting portions." @default.
• W1843075121 created "2016-06-24" @default.
• W1843075121 creator A5031274171 @default.
• W1843075121 creator A5064068441 @default.
• W1843075121 date "2015-08-02" @default.
• W1843075121 modified "2023-09-26" @default.
• W1843075121 title "Molecular dynamics study on protein–water interplay in the mechanogating of the bacterial mechanosensitive channel MscL" @default.
• W1843075121 cites W1074556531 @default.
• W1843075121 cites W1933841971 @default.
• W1843075121 cites W1963727244 @default.
• W1843075121 cites W1974549176 @default.
• W1843075121 cites W1983251302 @default.
• W1843075121 cites W1986668651 @default.
• W1843075121 cites W1988150205 @default.
• W1843075121 cites W1990958959 @default.
• W1843075121 cites W1993588987 @default.
• W1843075121 cites W2012608189 @default.
• W1843075121 cites W2014895510 @default.
• W1843075121 cites W2023405416 @default.
• W1843075121 cites W2027408247 @default.
• W1843075121 cites W2029667189 @default.
• W1843075121 cites W2036145275 @default.
• W1843075121 cites W2040923822 @default.
• W1843075121 cites W2043901383 @default.
• W1843075121 cites W2045540516 @default.
• W1843075121 cites W2048009063 @default.
• W1843075121 cites W2056248793 @default.
• W1843075121 cites W2067174909 @default.
• W1843075121 cites W2071195125 @default.
• W1843075121 cites W2080016998 @default.
• W1843075121 cites W2083517980 @default.
• W1843075121 cites W2086304639 @default.
• W1843075121 cites W2086354121 @default.
• W1843075121 cites W2089787695 @default.
• W1843075121 cites W2091722803 @default.
• W1843075121 cites W2097523022 @default.
• W1843075121 cites W2102978118 @default.
• W1843075121 cites W2103815459 @default.
• W1843075121 cites W2104129019 @default.
• W1843075121 cites W2110669138 @default.
• W1843075121 cites W2125942201 @default.
• W1843075121 cites W2131223624 @default.
• W1843075121 cites W2143291390 @default.
• W1843075121 cites W2147869016 @default.
• W1843075121 cites W2155797062 @default.
• W1843075121 cites W2159772052 @default.
• W1843075121 cites W2159958561 @default.
• W1843075121 cites W2165254952 @default.
• W1843075121 doi "https://doi.org/10.1007/s00249-015-1065-2" @default.
• W1843075121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4562998" @default.
• W1843075121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26233760" @default.
• W1843075121 hasPublicationYear "2015" @default.
• W1843075121 type Work @default.
• W1843075121 sameAs 1843075121 @default.
• W1843075121 citedByCount "11" @default.
• W1843075121 countsByYear W18430751212015 @default.
• W1843075121 countsByYear W18430751212016 @default.
• W1843075121 countsByYear W18430751212017 @default.
• W1843075121 countsByYear W18430751212018 @default.
• W1843075121 countsByYear W18430751212020 @default.
• W1843075121 countsByYear W18430751212021 @default.
• W1843075121 countsByYear W18430751212023 @default.
• W1843075121 crossrefType "journal-article" @default.
• W1843075121 hasAuthorship W1843075121A5031274171 @default.
• W1843075121 hasAuthorship W1843075121A5064068441 @default.
• W1843075121 hasBestOaLocation W18430751211 @default.
• W1843075121 hasConcept C112887158 @default.
• W1843075121 hasConcept C119049451 @default.
• W1843075121 hasConcept C12554922 @default.
• W1843075121 hasConcept C134514944 @default.
• W1843075121 hasConcept C147597530 @default.
• W1843075121 hasConcept C159467904 @default.
• W1843075121 hasConcept C159985019 @default.
• W1843075121 hasConcept C170493617 @default.
• W1843075121 hasConcept C171250308 @default.
• W1843075121 hasConcept C178790620 @default.
• W1843075121 hasConcept C185592680 @default.
• W1843075121 hasConcept C18903297 @default.
• W1843075121 hasConcept C192562407 @default.
• W1843075121 hasConcept C194544171 @default.
• W1843075121 hasConcept C2777339483 @default.
• W1843075121 hasConcept C2778530040 @default.
• W1843075121 hasConcept C2779965526 @default.
• W1843075121 hasConcept C32909587 @default.
• W1843075121 hasConcept C4001165 @default.
• W1843075121 hasConcept C41625074 @default.
• W1843075121 hasConcept C50254741 @default.
• W1843075121 hasConcept C55493867 @default.
• W1843075121 hasConcept C59593255 @default.
• W1843075121 hasConcept C71240020 @default.
• W1843075121 hasConcept C8010536 @default.
• W1843075121 hasConcept C86803240 @default.
• W1843075121 hasConceptScore W1843075121C112887158 @default.
• W1843075121 hasConceptScore W1843075121C119049451 @default.
• W1843075121 hasConceptScore W1843075121C12554922 @default.
• W1843075121 hasConceptScore W1843075121C134514944 @default.
• W1843075121 hasConceptScore W1843075121C147597530 @default.
• W1843075121 hasConceptScore W1843075121C159467904 @default.

• next