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- W1843121572 abstract "Memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, is used for treatment of patients with Alzheimer's disease. The mechanisms of memantine in relieving cognitive and behavioral symptoms are unclear, and this study attempts to elucidate its action on network and synaptic functions of the hippocampus. The effects of memantine on electrographic activity and hippocampal long-term potentiation (LTP) were investigated in freely moving rats. Basal dendritic excitation on hippocampal CA1 pyramidal cells showed a robust LTP after theta-frequency primed bursts, and the LTP was higher after 5-10 mg/kg intraperitoneal (ip) memantine pretreatment, as compared with saline pretreatment. Injection of scopolamine (5 mg/kg ip) before memantine failed to block the LTP-enhancing effect of memantine. Memantine as compared with saline pretreatment did not affect the LTP after an afterdischarge induced by high-frequency (200-Hz) train stimulation. Memantine (5 or 10 mg/kg ip) significantly enhanced gamma oscillations in the hippocampal local field potentials of 40-100 Hz during walking and awake immobility. Memantine at 10 mg/kg ip, but not at 5 mg/kg ip, increased prepulse inhibition of the acoustic startle response, while both 5 and 10 mg/kg ip memantine enhanced the acoustic startle response as compared with saline-injected rats. These electrophysiological and behavioral effects of memantine are unique among N-methyl-D-aspartate receptor antagonists but are consistent with memantine's effects in improving cognitive and sensorimotor functions of Alzheimer's patients." @default.
- W1843121572 created "2016-06-24" @default.
- W1843121572 creator A5007508597 @default.
- W1843121572 creator A5060358648 @default.
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- W1843121572 date "2015-09-01" @default.
- W1843121572 modified "2023-09-24" @default.
- W1843121572 title "Effects of memantine on hippocampal long-term potentiation, gamma activity, and sensorimotor gating in freely moving rats" @default.
- W1843121572 cites W1498877627 @default.
- W1843121572 cites W169227183 @default.
- W1843121572 cites W1963782016 @default.
- W1843121572 cites W1966103992 @default.
- W1843121572 cites W1972237620 @default.
- W1843121572 cites W197594573 @default.
- W1843121572 cites W1977239057 @default.
- W1843121572 cites W1978192104 @default.
- W1843121572 cites W1980340730 @default.
- W1843121572 cites W1983949152 @default.
- W1843121572 cites W1984305433 @default.
- W1843121572 cites W1990560606 @default.
- W1843121572 cites W1995718400 @default.
- W1843121572 cites W1999027550 @default.
- W1843121572 cites W2002827758 @default.
- W1843121572 cites W2007495000 @default.
- W1843121572 cites W2018071275 @default.
- W1843121572 cites W2019110724 @default.
- W1843121572 cites W2019532214 @default.
- W1843121572 cites W2020068013 @default.
- W1843121572 cites W2020245695 @default.
- W1843121572 cites W2028884770 @default.
- W1843121572 cites W2029056592 @default.
- W1843121572 cites W2034309372 @default.
- W1843121572 cites W2036025389 @default.
- W1843121572 cites W2036433706 @default.
- W1843121572 cites W2037845177 @default.
- W1843121572 cites W2039607980 @default.
- W1843121572 cites W2047347093 @default.
- W1843121572 cites W2048920034 @default.
- W1843121572 cites W2050198757 @default.
- W1843121572 cites W2051805052 @default.
- W1843121572 cites W2052742260 @default.
- W1843121572 cites W2062858206 @default.
- W1843121572 cites W2063177210 @default.
- W1843121572 cites W2064188040 @default.
- W1843121572 cites W2065818161 @default.
- W1843121572 cites W2068627574 @default.
- W1843121572 cites W2072465507 @default.
- W1843121572 cites W2074069151 @default.
- W1843121572 cites W2074417504 @default.
- W1843121572 cites W2078980144 @default.
- W1843121572 cites W2084182228 @default.
- W1843121572 cites W2084956941 @default.
- W1843121572 cites W2095060637 @default.
- W1843121572 cites W2102170600 @default.
- W1843121572 cites W2106259210 @default.
- W1843121572 cites W2110350185 @default.
- W1843121572 cites W2113476104 @default.
- W1843121572 cites W2114163624 @default.
- W1843121572 cites W2120508643 @default.
- W1843121572 cites W2123244021 @default.
- W1843121572 cites W2125737923 @default.
- W1843121572 cites W2128216497 @default.
- W1843121572 cites W2128815184 @default.
- W1843121572 cites W2133958927 @default.
- W1843121572 cites W2138883123 @default.
- W1843121572 cites W2139603174 @default.
- W1843121572 cites W2140506009 @default.
- W1843121572 cites W2146060653 @default.
- W1843121572 cites W2146204489 @default.
- W1843121572 cites W2147654688 @default.
- W1843121572 cites W2152511855 @default.
- W1843121572 cites W2155844685 @default.
- W1843121572 cites W2156203011 @default.
- W1843121572 cites W2158137297 @default.
- W1843121572 cites W2161102922 @default.
- W1843121572 cites W2163032657 @default.
- W1843121572 cites W2166659328 @default.
- W1843121572 cites W2170085655 @default.
- W1843121572 cites W2325918644 @default.
- W1843121572 cites W2404313594 @default.
- W1843121572 cites W299646246 @default.
- W1843121572 cites W4234060991 @default.
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- W1843121572 doi "https://doi.org/10.1016/j.neurobiolaging.2015.05.017" @default.
- W1843121572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26119223" @default.
- W1843121572 hasPublicationYear "2015" @default.
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