FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1843544875> ?p ?o ?g. }

• W1843544875 endingPage "2191" @default.
• W1843544875 startingPage "2183" @default.
• W1843544875 abstract "The hepatitis C virus (HCV) genome encodes two envelope glycoproteins (E1 and E2). These glycoproteins interact to formin a noncovalent heterodimeric complex which is retained in the endoplasmic reticulum (ER). To identify whether E1 and/or E2 contains an ER-targeting signal potentially involved in ER retention of the E1-E2 complex, these proteins were expressed alone and their intracellular localization was studied. Due to misfolding of E1 in the absence of E2, no conclusion on the localization of its native form could be drawn from the expression of E1 alone. E2 expressed in the absence of E1 was shown to be retained in the ER similarly to E1-E2 complex. Chimeric proteins in which E2 domains were exchanged with corresponding domains of a protein normally transported to the plasma membrane (CD4) were constructed to identify the sequence responsible for its ER retention. The transmembrane domain (TMD) of E2 (C-terminal 29 amino acids) was shown to be sufficient for retention of the ectodomain of CD4 in the ER compartment. Replacement of the E2 TMD by the anchor signal of CD4 or a glycosyl phosphatidylinositol (GPI) moiety led to its expression on the cell surface. In addition, replacement of the E2 TMD by the anchor signal of CD4 or a GPI moiety abolished the formation of E1-E2 complexes. Together, these results suggest that, besides having a role as a membrane anchor, the TMD of E2 is involved in both complex formation and intracellular localization." @default.
• W1843544875 created "2016-06-24" @default.
• W1843544875 creator A5003799959 @default.
• W1843544875 creator A5041483008 @default.
• W1843544875 creator A5045022092 @default.
• W1843544875 creator A5066170317 @default.
• W1843544875 creator A5087727909 @default.
• W1843544875 date "1998-03-01" @default.
• W1843544875 modified "2023-10-14" @default.
• W1843544875 title "A Retention Signal Necessary and Sufficient for Endoplasmic Reticulum Localization Maps to the Transmembrane Domain of Hepatitis C Virus Glycoprotein E2" @default.
• W1843544875 cites W1502884286 @default.
• W1843544875 cites W1512482605 @default.
• W1843544875 cites W1551504213 @default.
• W1843544875 cites W1597908522 @default.
• W1843544875 cites W1602629787 @default.
• W1843544875 cites W1635062911 @default.
• W1843544875 cites W168389016 @default.
• W1843544875 cites W170304149 @default.
• W1843544875 cites W1738645663 @default.
• W1843544875 cites W1886781491 @default.
• W1843544875 cites W1928740638 @default.
• W1843544875 cites W1970019795 @default.
• W1843544875 cites W1973504221 @default.
• W1843544875 cites W1991599869 @default.
• W1843544875 cites W2005411001 @default.
• W1843544875 cites W2005768267 @default.
• W1843544875 cites W2022125636 @default.
• W1843544875 cites W2022987420 @default.
• W1843544875 cites W2027733213 @default.
• W1843544875 cites W2037137513 @default.
• W1843544875 cites W2048510206 @default.
• W1843544875 cites W2060311116 @default.
• W1843544875 cites W2062044807 @default.
• W1843544875 cites W2062979587 @default.
• W1843544875 cites W2064304037 @default.
• W1843544875 cites W2075554603 @default.
• W1843544875 cites W2077173353 @default.
• W1843544875 cites W2077513922 @default.
• W1843544875 cites W2079854145 @default.
• W1843544875 cites W2082284995 @default.
• W1843544875 cites W2083337563 @default.
• W1843544875 cites W2094913735 @default.
• W1843544875 cites W2114857960 @default.
• W1843544875 cites W2125020009 @default.
• W1843544875 cites W2130661443 @default.
• W1843544875 cites W2133449590 @default.
• W1843544875 cites W2145478668 @default.
• W1843544875 cites W2146674279 @default.
• W1843544875 cites W2147202849 @default.
• W1843544875 cites W2152793674 @default.
• W1843544875 cites W2160425277 @default.
• W1843544875 cites W2161741847 @default.
• W1843544875 cites W2171698623 @default.
• W1843544875 cites W2172683288 @default.
• W1843544875 cites W2398253004 @default.
• W1843544875 cites W2408822320 @default.
• W1843544875 cites W2412567846 @default.
• W1843544875 cites W2964302381 @default.
• W1843544875 doi "https://doi.org/10.1128/jvi.72.3.2183-2191.1998" @default.
• W1843544875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/109514" @default.
• W1843544875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9499075" @default.
• W1843544875 hasPublicationYear "1998" @default.
• W1843544875 type Work @default.
• W1843544875 sameAs 1843544875 @default.
• W1843544875 citedByCount "243" @default.
• W1843544875 countsByYear W18435448752012 @default.
• W1843544875 countsByYear W18435448752013 @default.
• W1843544875 countsByYear W18435448752014 @default.
• W1843544875 countsByYear W18435448752015 @default.
• W1843544875 countsByYear W18435448752016 @default.
• W1843544875 countsByYear W18435448752017 @default.
• W1843544875 countsByYear W18435448752018 @default.
• W1843544875 countsByYear W18435448752019 @default.
• W1843544875 countsByYear W18435448752021 @default.
• W1843544875 countsByYear W18435448752022 @default.
• W1843544875 countsByYear W18435448752023 @default.
• W1843544875 crossrefType "journal-article" @default.
• W1843544875 hasAuthorship W1843544875A5003799959 @default.
• W1843544875 hasAuthorship W1843544875A5041483008 @default.
• W1843544875 hasAuthorship W1843544875A5045022092 @default.
• W1843544875 hasAuthorship W1843544875A5066170317 @default.
• W1843544875 hasAuthorship W1843544875A5087727909 @default.
• W1843544875 hasBestOaLocation W18435448751 @default.
• W1843544875 hasConcept C1009742 @default.
• W1843544875 hasConcept C104317684 @default.
• W1843544875 hasConcept C108625454 @default.
• W1843544875 hasConcept C118892022 @default.
• W1843544875 hasConcept C143065580 @default.
• W1843544875 hasConcept C158617107 @default.
• W1843544875 hasConcept C162740809 @default.
• W1843544875 hasConcept C170493617 @default.
• W1843544875 hasConcept C24530287 @default.
• W1843544875 hasConcept C2777459641 @default.
• W1843544875 hasConcept C2778043179 @default.
• W1843544875 hasConcept C515207424 @default.
• W1843544875 hasConcept C55493867 @default.
• W1843544875 hasConcept C86803240 @default.
• W1843544875 hasConcept C95444343 @default.

• next