FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1843613114> ?p ?o ?g. }

• W1843613114 endingPage "3741" @default.
• W1843613114 startingPage "3730" @default.
• W1843613114 abstract "Immunity to tumor Ags in patients is typically weak and not therapeutic. We have identified a new mechanism by which potentially immunogenic glycoprotein tumor Ags, such as MUC1, fail to stimulate strong immune responses. MUC1 is a heavily glycosylated membrane protein that is also present in soluble form in sera and ascites of cancer patients. We show that this soluble protein is readily taken up by dendritic cells (DC), but is not transported to late endosomes or MHC class II compartments for processing and binding to class II MHC. MUC1 uptake is mediated by the mannose receptor, and the protein is then retained long term in early endosomes without degradation. Long-term retention of MUC1 does not interfere with the ability of DC to process and present other Ags. We also demonstrate inhibited processing of another important glycoprotein tumor Ag, HER-2/neu. This may, therefore, be a frequent obstacle to presentation of tumor Ags and an important consideration in the design of cancer vaccines. It should be possible to overcome this obstacle by providing DC with a form of tumor Ag that can be better processed. For MUC1 we show that a 140-aa-long synthetic peptide is very efficiently processed by DC." @default.
• W1843613114 created "2016-06-24" @default.
• W1843613114 creator A5024170610 @default.
• W1843613114 creator A5035444874 @default.
• W1843613114 creator A5063419335 @default.
• W1843613114 creator A5072751145 @default.
• W1843613114 creator A5088924932 @default.
• W1843613114 date "2000-10-01" @default.
• W1843613114 modified "2023-09-30" @default.
• W1843613114 title "The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells" @default.
• W1843613114 cites W133195234 @default.
• W1843613114 cites W1513644368 @default.
• W1843613114 cites W1540025977 @default.
• W1843613114 cites W1554669092 @default.
• W1843613114 cites W1554895529 @default.
• W1843613114 cites W1579143707 @default.
• W1843613114 cites W1603697150 @default.
• W1843613114 cites W1608651908 @default.
• W1843613114 cites W1655423342 @default.
• W1843613114 cites W1707974959 @default.
• W1843613114 cites W18738890 @default.
• W1843613114 cites W1943191147 @default.
• W1843613114 cites W1968299218 @default.
• W1843613114 cites W1978070009 @default.
• W1843613114 cites W1978416272 @default.
• W1843613114 cites W1979397217 @default.
• W1843613114 cites W1987589866 @default.
• W1843613114 cites W1998733027 @default.
• W1843613114 cites W2000816527 @default.
• W1843613114 cites W2003042213 @default.
• W1843613114 cites W2008980266 @default.
• W1843613114 cites W2009481222 @default.
• W1843613114 cites W2012952808 @default.
• W1843613114 cites W2013686456 @default.
• W1843613114 cites W2013857975 @default.
• W1843613114 cites W2014359809 @default.
• W1843613114 cites W2016198585 @default.
• W1843613114 cites W2022331490 @default.
• W1843613114 cites W2025107135 @default.
• W1843613114 cites W2031458917 @default.
• W1843613114 cites W2035503573 @default.
• W1843613114 cites W2040209854 @default.
• W1843613114 cites W2061476447 @default.
• W1843613114 cites W2065648686 @default.
• W1843613114 cites W2071168946 @default.
• W1843613114 cites W2077927974 @default.
• W1843613114 cites W2087526889 @default.
• W1843613114 cites W2092312916 @default.
• W1843613114 cites W2095352046 @default.
• W1843613114 cites W2097009175 @default.
• W1843613114 cites W2098248666 @default.
• W1843613114 cites W2104603012 @default.
• W1843613114 cites W2111695773 @default.
• W1843613114 cites W2118111782 @default.
• W1843613114 cites W2131761283 @default.
• W1843613114 cites W2132932170 @default.
• W1843613114 cites W2140950597 @default.
• W1843613114 cites W2149938812 @default.
• W1843613114 cites W2159153404 @default.
• W1843613114 cites W2161249891 @default.
• W1843613114 cites W2163420537 @default.
• W1843613114 cites W2462089688 @default.
• W1843613114 doi "https://doi.org/10.4049/jimmunol.165.7.3730" @default.
• W1843613114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11034378" @default.
• W1843613114 hasPublicationYear "2000" @default.
• W1843613114 type Work @default.
• W1843613114 sameAs 1843613114 @default.
• W1843613114 citedByCount "157" @default.
• W1843613114 countsByYear W18436131142012 @default.
• W1843613114 countsByYear W18436131142013 @default.
• W1843613114 countsByYear W18436131142014 @default.
• W1843613114 countsByYear W18436131142015 @default.
• W1843613114 countsByYear W18436131142016 @default.
• W1843613114 countsByYear W18436131142017 @default.
• W1843613114 countsByYear W18436131142018 @default.
• W1843613114 countsByYear W18436131142019 @default.
• W1843613114 countsByYear W18436131142021 @default.
• W1843613114 countsByYear W18436131142022 @default.
• W1843613114 countsByYear W18436131142023 @default.
• W1843613114 crossrefType "journal-article" @default.
• W1843613114 hasAuthorship W1843613114A5024170610 @default.
• W1843613114 hasAuthorship W1843613114A5035444874 @default.
• W1843613114 hasAuthorship W1843613114A5063419335 @default.
• W1843613114 hasAuthorship W1843613114A5072751145 @default.
• W1843613114 hasAuthorship W1843613114A5088924932 @default.
• W1843613114 hasBestOaLocation W18436131141 @default.
• W1843613114 hasConcept C102747710 @default.
• W1843613114 hasConcept C108249834 @default.
• W1843613114 hasConcept C108625454 @default.
• W1843613114 hasConcept C147483822 @default.
• W1843613114 hasConcept C170493617 @default.
• W1843613114 hasConcept C170627219 @default.
• W1843613114 hasConcept C185592680 @default.
• W1843613114 hasConcept C202751555 @default.
• W1843613114 hasConcept C203014093 @default.
• W1843613114 hasConcept C206212055 @default.
• W1843613114 hasConcept C207936829 @default.
• W1843613114 hasConcept C2776090121 @default.

• next