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• W1844077757 abstract "Chemical exchange saturation transfer (CEST) is a contrast mechanism enhancing low-concentration molecules through saturation transfer from their exchangeable protons to bulk water. Often many scans are acquired to form a Z-spectrum, making the CEST method time-consuming. Here, an ultrafast localized CEST-spectroscopy with PRESS (UCEPR) is proposed to obtain the entire Z-spectrum of a voxel using only two scans, significantly accelerating CEST.The approach combines ultrafast nonlocalized CEST spectroscopy with localization using PRESS. A field gradient is applied concurrently with the saturation pulse producing simultaneous saturation of all Z-spectrum frequencies that are also spatially encoded. A readout gradient during data acquisition resolves the spatial dependence of the CEST responses into frequency. UCEPR was tested on a 3T scanner both in phantoms and in vivo.In phantoms, a fast Z-spectroscopy acquisition of multiple pH-variant iopamidol samples was achieved with four- to seven-fold acceleration as compared to the conventional CEST methods. In vivo, amide proton transfer (APT) in white matter of healthy human brain was measured rapidly in 48 s and with high frequency resolution (≤ 0.2 ppm).Compared with conventional CEST methods, UCEPR has the advantage of rapidly acquiring high-resolution Z-spectra. Potential in vivo applications include ultrafast localized Z-spectroscopy, quantitative, or dynamic CEST studies." @default.
• W1844077757 created "2016-06-24" @default.
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• W1844077757 date "2015-05-29" @default.
• W1844077757 modified "2023-09-28" @default.
• W1844077757 title "UCEPR: Ultrafast localized CEST-spectroscopy with PRESS in phantoms and in vivo" @default.
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• W1844077757 doi "https://doi.org/10.1002/mrm.25780" @default.
• W1844077757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4663188" @default.
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• W1844077757 hasPublicationYear "2015" @default.
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