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• W1844082008 abstract "This review aims at presenting a new concept pertaining to the development of antioxidants, namely, to evolve from disease-oriented therapy to mechanism-oriented therapy. Using as our illustrative example is DJ-1, a homodimeric protein that is ubiquitously expressed in a variety of mammalian tissues, including the brain, and is found in the matrix and the intermembrane space of the mitochondria. DJ-1 is known to be an endogenous antioxidant against cancer, neurodegeneration and cardiovascular diseases, of which oxidative stress plays a causal role. Interestingly, the mechanistic targets of DJ-1 as an antioxidant, including Daxx, Nrf2, thioredoxin, glutathione, α-synuclein, PTEN/PI3K/Akt, and Pink/Parkin are also associated with those oxidative stress-related diseases. Furthermore, activators of DJ-1 are available in the form of mortalin, phenylbutyrate and NAD(P)H:quinone oxidoreductase 1. It follows that activation of DJ-1 as a common endogenous antioxidant provides a new strategy against cancer, neurodegeneration and cardiovascular diseases. Since clinical trials on exogenous application of the known antioxidants have basically failed, an alternative approach would logically be to activate the endogenous antioxidants that are already present in the appropriate cellular locale where elevated oxidative stress is the culprit for the disease. At the same time, since oxidative stress is a common denominator among cancer, neurodegeneration and cardiovascular diseases, development of antioxidant therapy should target the reduction in reactive oxygen species. Instead of focusing on disease-oriented therapy, pharmaceutical companies should concentrate on developing agents and dosing schemes for effective activation of the endogenous antioxidants that are associated with a multitude of oxidative stress-related diseases (mechanism-oriented therapy)." @default.
• W1844082008 created "2016-06-24" @default.
• W1844082008 creator A5067438833 @default.
• W1844082008 creator A5080500932 @default.
• W1844082008 date "2015-12-01" @default.
• W1844082008 modified "2023-10-16" @default.
• W1844082008 title "Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1" @default.
• W1844082008 cites W1563044851 @default.
• W1844082008 cites W1678920698 @default.
• W1844082008 cites W1921965616 @default.
• W1844082008 cites W1967603366 @default.
• W1844082008 cites W1969268163 @default.
• W1844082008 cites W1973474734 @default.
• W1844082008 cites W1974843588 @default.
• W1844082008 cites W1977166619 @default.
• W1844082008 cites W1977990240 @default.
• W1844082008 cites W1981550027 @default.
• W1844082008 cites W1990847293 @default.
• W1844082008 cites W1991505929 @default.
• W1844082008 cites W1993961540 @default.
• W1844082008 cites W1993991849 @default.
• W1844082008 cites W1994367478 @default.
• W1844082008 cites W1995412458 @default.
• W1844082008 cites W1995731966 @default.
• W1844082008 cites W1999469282 @default.
• W1844082008 cites W2003386890 @default.
• W1844082008 cites W2005322339 @default.
• W1844082008 cites W2008825369 @default.
• W1844082008 cites W2010009570 @default.
• W1844082008 cites W2010728263 @default.
• W1844082008 cites W2010914316 @default.
• W1844082008 cites W2012112859 @default.
• W1844082008 cites W2020170893 @default.
• W1844082008 cites W2021294790 @default.
• W1844082008 cites W2022893194 @default.
• W1844082008 cites W2026841498 @default.
• W1844082008 cites W2027177342 @default.
• W1844082008 cites W2027287873 @default.
• W1844082008 cites W2028099760 @default.
• W1844082008 cites W2029854095 @default.
• W1844082008 cites W2031898930 @default.
• W1844082008 cites W2036660401 @default.
• W1844082008 cites W2037079848 @default.
• W1844082008 cites W2040305008 @default.
• W1844082008 cites W2046969478 @default.
• W1844082008 cites W2053784053 @default.
• W1844082008 cites W2056736498 @default.
• W1844082008 cites W2059209321 @default.
• W1844082008 cites W2063089997 @default.
• W1844082008 cites W2065710720 @default.
• W1844082008 cites W2066040432 @default.
• W1844082008 cites W2070766926 @default.
• W1844082008 cites W2074397899 @default.
• W1844082008 cites W2075660066 @default.
• W1844082008 cites W2078312014 @default.
• W1844082008 cites W2081340075 @default.
• W1844082008 cites W2087821811 @default.
• W1844082008 cites W2088869582 @default.
• W1844082008 cites W2091767225 @default.
• W1844082008 cites W2097767970 @default.
• W1844082008 cites W2097777783 @default.
• W1844082008 cites W2098689751 @default.
• W1844082008 cites W2104382960 @default.
• W1844082008 cites W2111752734 @default.
• W1844082008 cites W2119028277 @default.
• W1844082008 cites W2121646473 @default.
• W1844082008 cites W2122291732 @default.
• W1844082008 cites W2128348076 @default.
• W1844082008 cites W2129755489 @default.
• W1844082008 cites W2130792966 @default.
• W1844082008 cites W2133203435 @default.
• W1844082008 cites W2135912999 @default.
• W1844082008 cites W2138336750 @default.
• W1844082008 cites W2141122353 @default.
• W1844082008 cites W2141322891 @default.
• W1844082008 cites W2141918542 @default.
• W1844082008 cites W2143048992 @default.
• W1844082008 cites W2143843448 @default.
• W1844082008 cites W2145664571 @default.
• W1844082008 cites W2150634893 @default.
• W1844082008 cites W2151725579 @default.
• W1844082008 cites W2153706510 @default.
• W1844082008 cites W2154283765 @default.
• W1844082008 cites W2155017406 @default.
• W1844082008 cites W2160681852 @default.
• W1844082008 cites W2164298199 @default.
• W1844082008 cites W2164313332 @default.
• W1844082008 cites W2165201727 @default.
• W1844082008 cites W2167054321 @default.
• W1844082008 cites W2168709353 @default.
• W1844082008 cites W2169466661 @default.
• W1844082008 cites W2169467581 @default.
• W1844082008 cites W2170748127 @default.
• W1844082008 cites W2171222510 @default.
• W1844082008 cites W2171873547 @default.
• W1844082008 cites W2317201281 @default.
• W1844082008 cites W2327037425 @default.
• W1844082008 cites W2329808372 @default.

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