Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844156986> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1844156986 endingPage "e368" @default.
- W1844156986 startingPage "e365" @default.
- W1844156986 abstract "Diabet. Med. 29, e365–e368 (2012) Aim Endothelial dysfunction is defined by reduced bioavailability of nitric oxide and has been shown to be associated with cardiovascular risk. The global arginine bioavailability ratio and the arginine to ornithine ratio have recently been shown to be associated with cardiovascular outcome in patients with coronary artery disease. The aim of our study was to investigate the impact of a multifactorial risk factor intervention in subjects with Type 2 diabetes on these two potential new cardiovascular surrogate parameters. Methods In a single-centre and prospective study, we investigated 41 patients with Type 2 diabetes not reaching treatment targets according to current local diabetes guidelines in two out of three of the following measurements: HbA1c LDL cholesterol 2.6 or blood pressure. Within 3 months, therapy was intensified according to current guidelines aiming to reach the treatment targets. At baseline and 3 months, arginine, ornithine and citrulline were chromatographically determined after pre-column-derivatization followed by fluorescent detection, and arginine bioavailability ratios were calculated. Results Intensified risk factor management significantly improved the global arginine bioavailability ratio (0.33 ± 0.12 at baseline vs. 0.38 ± 0.14 after 3 months; P = 0.018). A significant improvement was only seen in patients with short diabetes duration (< 5 years), whereas in patients with longer diabetes duration improvement did not reach statistical significance. Conclusion In patients with Type 2 diabetes, intensified risk factor management improves arginine bioavailability ratios. Duration of diabetes seems to be an important factor influencing the capacity of the global arginine bioavailability ratio improvement." @default.
- W1844156986 created "2016-06-24" @default.
- W1844156986 creator A5013407088 @default.
- W1844156986 creator A5023877066 @default.
- W1844156986 creator A5035066978 @default.
- W1844156986 creator A5054875590 @default.
- W1844156986 creator A5056821482 @default.
- W1844156986 creator A5067997007 @default.
- W1844156986 date "2012-09-18" @default.
- W1844156986 modified "2023-09-29" @default.
- W1844156986 title "Multifactorial risk factor intervention in patients with Type 2 diabetes improves arginine bioavailability ratios" @default.
- W1844156986 cites W172609984 @default.
- W1844156986 cites W2002525434 @default.
- W1844156986 cites W2003319782 @default.
- W1844156986 cites W2014759828 @default.
- W1844156986 cites W2019338486 @default.
- W1844156986 cites W2049292864 @default.
- W1844156986 cites W2123946565 @default.
- W1844156986 cites W2136055847 @default.
- W1844156986 cites W2139634859 @default.
- W1844156986 cites W2147663252 @default.
- W1844156986 cites W2166947330 @default.
- W1844156986 cites W2170271198 @default.
- W1844156986 cites W2171294019 @default.
- W1844156986 cites W2297753288 @default.
- W1844156986 cites W2311863050 @default.
- W1844156986 doi "https://doi.org/10.1111/j.1464-5491.2012.03743.x" @default.
- W1844156986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22803961" @default.
- W1844156986 hasPublicationYear "2012" @default.
- W1844156986 type Work @default.
- W1844156986 sameAs 1844156986 @default.
- W1844156986 citedByCount "23" @default.
- W1844156986 countsByYear W18441569862013 @default.
- W1844156986 countsByYear W18441569862014 @default.
- W1844156986 countsByYear W18441569862015 @default.
- W1844156986 countsByYear W18441569862016 @default.
- W1844156986 countsByYear W18441569862017 @default.
- W1844156986 countsByYear W18441569862018 @default.
- W1844156986 countsByYear W18441569862019 @default.
- W1844156986 countsByYear W18441569862020 @default.
- W1844156986 countsByYear W18441569862022 @default.
- W1844156986 countsByYear W18441569862023 @default.
- W1844156986 crossrefType "journal-article" @default.
- W1844156986 hasAuthorship W1844156986A5013407088 @default.
- W1844156986 hasAuthorship W1844156986A5023877066 @default.
- W1844156986 hasAuthorship W1844156986A5035066978 @default.
- W1844156986 hasAuthorship W1844156986A5054875590 @default.
- W1844156986 hasAuthorship W1844156986A5056821482 @default.
- W1844156986 hasAuthorship W1844156986A5067997007 @default.
- W1844156986 hasConcept C126322002 @default.
- W1844156986 hasConcept C134018914 @default.
- W1844156986 hasConcept C181389837 @default.
- W1844156986 hasConcept C185592680 @default.
- W1844156986 hasConcept C2777180221 @default.
- W1844156986 hasConcept C2777468819 @default.
- W1844156986 hasConcept C50440223 @default.
- W1844156986 hasConcept C515207424 @default.
- W1844156986 hasConcept C55493867 @default.
- W1844156986 hasConcept C555293320 @default.
- W1844156986 hasConcept C71924100 @default.
- W1844156986 hasConcept C90924648 @default.
- W1844156986 hasConcept C98274493 @default.
- W1844156986 hasConceptScore W1844156986C126322002 @default.
- W1844156986 hasConceptScore W1844156986C134018914 @default.
- W1844156986 hasConceptScore W1844156986C181389837 @default.
- W1844156986 hasConceptScore W1844156986C185592680 @default.
- W1844156986 hasConceptScore W1844156986C2777180221 @default.
- W1844156986 hasConceptScore W1844156986C2777468819 @default.
- W1844156986 hasConceptScore W1844156986C50440223 @default.
- W1844156986 hasConceptScore W1844156986C515207424 @default.
- W1844156986 hasConceptScore W1844156986C55493867 @default.
- W1844156986 hasConceptScore W1844156986C555293320 @default.
- W1844156986 hasConceptScore W1844156986C71924100 @default.
- W1844156986 hasConceptScore W1844156986C90924648 @default.
- W1844156986 hasConceptScore W1844156986C98274493 @default.
- W1844156986 hasIssue "10" @default.
- W1844156986 hasLocation W18441569861 @default.
- W1844156986 hasLocation W18441569862 @default.
- W1844156986 hasOpenAccess W1844156986 @default.
- W1844156986 hasPrimaryLocation W18441569861 @default.
- W1844156986 hasRelatedWork W1967095436 @default.
- W1844156986 hasRelatedWork W1982094574 @default.
- W1844156986 hasRelatedWork W1988703247 @default.
- W1844156986 hasRelatedWork W2009418740 @default.
- W1844156986 hasRelatedWork W2011792914 @default.
- W1844156986 hasRelatedWork W2014884254 @default.
- W1844156986 hasRelatedWork W2045993936 @default.
- W1844156986 hasRelatedWork W2111546536 @default.
- W1844156986 hasRelatedWork W2135910067 @default.
- W1844156986 hasRelatedWork W2168702221 @default.
- W1844156986 hasVolume "29" @default.
- W1844156986 isParatext "false" @default.
- W1844156986 isRetracted "false" @default.
- W1844156986 magId "1844156986" @default.
- W1844156986 workType "article" @default.