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• W1844193885 abstract "Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-neuronal communication in response to profibrotic factors." @default.
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• W1844193885 date "2015-06-29" @default.
• W1844193885 modified "2023-10-11" @default.
• W1844193885 title "Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions" @default.
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• W1844193885 doi "https://doi.org/10.1038/nn.4054" @default.
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