Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844263858> ?p ?o ?g. }
- W1844263858 endingPage "148" @default.
- W1844263858 startingPage "124" @default.
- W1844263858 abstract "Publisher Summary This chapter focuses on research aimed at detecting age-related increases in oxidative damage to protein or lipid components of the mitochondrion. Aging has been associated with both an increase in oxidative damage to proteins and a decrease in protein turnover and repair. The age-related increase in protein modifications includes cross-linkages, fragmentation, carbonylation, glycation, and advanced glycation end-product formation. Several research support mitochondria as the primary source of reactive oxygen species (ROS). Hence, mitochondrial proteins—including the complexes of the electron transport chain and members of other metabolic pathways—are likely to be particularly susceptible to modifications as a result of oxidative damage. Certain cellular components are known to be sensitive to oxidative stress. Specifically, proteins containing iron-sulfur clusters (Fe–S proteins) are highly sensitive to superoxide. Polyunsaturated fatty acids of membrane lipids are susceptible to peroxidation by ROS. The lipid peroxides (lipid-OOH) formed can decompose in the presence of transition metals such as iron to give alkoxy (lipid-O) radicals. These lipid radicals may alter membrane fluidity and subsequently affect the activity of membrane-bound proteins and membrane permeability, ultimately leading to cell degeneration." @default.
- W1844263858 created "2016-06-24" @default.
- W1844263858 creator A5032465352 @default.
- W1844263858 creator A5036297723 @default.
- W1844263858 creator A5059066848 @default.
- W1844263858 creator A5074440927 @default.
- W1844263858 creator A5078541018 @default.
- W1844263858 date "2005-01-01" @default.
- W1844263858 modified "2023-10-16" @default.
- W1844263858 title "Mitochondrial" @default.
- W1844263858 cites W1482452656 @default.
- W1844263858 cites W1487552431 @default.
- W1844263858 cites W1489860413 @default.
- W1844263858 cites W1492322138 @default.
- W1844263858 cites W1503983308 @default.
- W1844263858 cites W1504584187 @default.
- W1844263858 cites W1506621956 @default.
- W1844263858 cites W1528834211 @default.
- W1844263858 cites W1536773986 @default.
- W1844263858 cites W1544851750 @default.
- W1844263858 cites W1544860636 @default.
- W1844263858 cites W1559173033 @default.
- W1844263858 cites W1559481538 @default.
- W1844263858 cites W1618846043 @default.
- W1844263858 cites W1737281046 @default.
- W1844263858 cites W1799692929 @default.
- W1844263858 cites W1802480460 @default.
- W1844263858 cites W1877873625 @default.
- W1844263858 cites W1930159471 @default.
- W1844263858 cites W1964299033 @default.
- W1844263858 cites W1964551999 @default.
- W1844263858 cites W1965009601 @default.
- W1844263858 cites W1965389195 @default.
- W1844263858 cites W1966800508 @default.
- W1844263858 cites W1967154926 @default.
- W1844263858 cites W1967291345 @default.
- W1844263858 cites W1968197570 @default.
- W1844263858 cites W1968262299 @default.
- W1844263858 cites W1969800514 @default.
- W1844263858 cites W1971104692 @default.
- W1844263858 cites W1972636956 @default.
- W1844263858 cites W1972850922 @default.
- W1844263858 cites W1973842058 @default.
- W1844263858 cites W1973851166 @default.
- W1844263858 cites W1974407610 @default.
- W1844263858 cites W1976273464 @default.
- W1844263858 cites W1979117383 @default.
- W1844263858 cites W1979516784 @default.
- W1844263858 cites W1979765208 @default.
- W1844263858 cites W1980137560 @default.
- W1844263858 cites W1980279798 @default.
- W1844263858 cites W1984552013 @default.
- W1844263858 cites W1985134135 @default.
- W1844263858 cites W1989818767 @default.
- W1844263858 cites W1991192746 @default.
- W1844263858 cites W1991238715 @default.
- W1844263858 cites W1993307171 @default.
- W1844263858 cites W1994517089 @default.
- W1844263858 cites W1995365852 @default.
- W1844263858 cites W1995530354 @default.
- W1844263858 cites W1996847332 @default.
- W1844263858 cites W1997842854 @default.
- W1844263858 cites W1997970054 @default.
- W1844263858 cites W1999232986 @default.
- W1844263858 cites W1999286267 @default.
- W1844263858 cites W2001210466 @default.
- W1844263858 cites W2004384294 @default.
- W1844263858 cites W2005261119 @default.
- W1844263858 cites W2005280808 @default.
- W1844263858 cites W2006132005 @default.
- W1844263858 cites W2009688381 @default.
- W1844263858 cites W2010376674 @default.
- W1844263858 cites W2012437147 @default.
- W1844263858 cites W2014887370 @default.
- W1844263858 cites W2015363963 @default.
- W1844263858 cites W2015411189 @default.
- W1844263858 cites W2016606318 @default.
- W1844263858 cites W2021078227 @default.
- W1844263858 cites W2021587119 @default.
- W1844263858 cites W2022982230 @default.
- W1844263858 cites W2025719835 @default.
- W1844263858 cites W2026525843 @default.
- W1844263858 cites W2026983299 @default.
- W1844263858 cites W2027321097 @default.
- W1844263858 cites W2029282672 @default.
- W1844263858 cites W2030135352 @default.
- W1844263858 cites W2031738386 @default.
- W1844263858 cites W2035973775 @default.
- W1844263858 cites W2036127346 @default.
- W1844263858 cites W2036988144 @default.
- W1844263858 cites W2037030851 @default.
- W1844263858 cites W2039198097 @default.
- W1844263858 cites W2042613416 @default.
- W1844263858 cites W2043603162 @default.
- W1844263858 cites W2043988673 @default.
- W1844263858 cites W2044897807 @default.
- W1844263858 cites W2046089054 @default.
- W1844263858 cites W2046589688 @default.