FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844276506> ?p ?o ?g. }

• W1844276506 endingPage "345" @default.
• W1844276506 startingPage "338" @default.
• W1844276506 abstract "Maturation of dendritic cells (DC) is critical to their development into potent APCs. Upon maturation, DC up-regulate the expression of MHC class II as well as costimulatory and adhesion molecules, all of which are important in Ag presentation. In addition, they undergo structural changes characterized by the expression of numerous long dendrites. Fascin is an actin-bundling protein that has been reported to be important for the development of dendrites. In this study, we evaluated fascin expression and function during DC maturation into potent APC. In vitro, treatment of bone marrow-derived DC (BM-DC) with GM-CSF resulted in increased levels of fascin expression. This increase correlated directly with an increase in MHC class II and B7-2 expression. Fascin expression was decreased by the addition of TGF-ss and increased by the addition TNF-alpha to the culture. These cytokines suppress or enhance DC maturation, respectively. Increased levels of fascin expression were found to correlate with increased APC activity in a one-way MLR. Specific inhibition of fascin expression, using antisense oligonucleotides, markedly reduced this APC allostimulatory activity. These data demonstrate that fascin expression correlates with DC maturation into APC, and it plays a significant role in the ability of DC to function as APC. This observation is the first evidence linking fascin-mediated dendrite formation with the APC activity of DC." @default.
• W1844276506 created "2016-06-24" @default.
• W1844276506 creator A5009477531 @default.
• W1844276506 creator A5013510546 @default.
• W1844276506 creator A5022837013 @default.
• W1844276506 creator A5085492328 @default.
• W1844276506 date "2001-01-01" @default.
• W1844276506 modified "2023-10-17" @default.
• W1844276506 title "Fascin Is Involved in the Antigen Presentation Activity of Mature Dendritic Cells" @default.
• W1844276506 cites W1510470032 @default.
• W1844276506 cites W1515963037 @default.
• W1844276506 cites W1516680782 @default.
• W1844276506 cites W1562981354 @default.
• W1844276506 cites W1661544713 @default.
• W1844276506 cites W1964931837 @default.
• W1844276506 cites W1976045232 @default.
• W1844276506 cites W1976409729 @default.
• W1844276506 cites W1987616397 @default.
• W1844276506 cites W1989914829 @default.
• W1844276506 cites W1996564646 @default.
• W1844276506 cites W1999239244 @default.
• W1844276506 cites W2010350911 @default.
• W1844276506 cites W2019286212 @default.
• W1844276506 cites W2019546595 @default.
• W1844276506 cites W2030463167 @default.
• W1844276506 cites W2037038285 @default.
• W1844276506 cites W2038481383 @default.
• W1844276506 cites W2046842929 @default.
• W1844276506 cites W2047007045 @default.
• W1844276506 cites W2049432379 @default.
• W1844276506 cites W2067464003 @default.
• W1844276506 cites W2077654197 @default.
• W1844276506 cites W2084093106 @default.
• W1844276506 cites W2092235636 @default.
• W1844276506 cites W2096152012 @default.
• W1844276506 cites W2100200230 @default.
• W1844276506 cites W2111275724 @default.
• W1844276506 cites W2120831204 @default.
• W1844276506 cites W2121604038 @default.
• W1844276506 cites W2126947721 @default.
• W1844276506 cites W2128137492 @default.
• W1844276506 cites W2132552157 @default.
• W1844276506 cites W2134004551 @default.
• W1844276506 cites W2135272173 @default.
• W1844276506 cites W2136841975 @default.
• W1844276506 cites W2146520700 @default.
• W1844276506 cites W2157069655 @default.
• W1844276506 cites W2163295981 @default.
• W1844276506 cites W2166676682 @default.
• W1844276506 cites W2166982025 @default.
• W1844276506 cites W2170293184 @default.
• W1844276506 cites W2171173320 @default.
• W1844276506 cites W2177327503 @default.
• W1844276506 cites W2263082259 @default.
• W1844276506 cites W90568390 @default.
• W1844276506 doi "https://doi.org/10.4049/jimmunol.166.1.338" @default.
• W1844276506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11123310" @default.
• W1844276506 hasPublicationYear "2001" @default.
• W1844276506 type Work @default.
• W1844276506 sameAs 1844276506 @default.
• W1844276506 citedByCount "127" @default.
• W1844276506 countsByYear W18442765062012 @default.
• W1844276506 countsByYear W18442765062013 @default.
• W1844276506 countsByYear W18442765062014 @default.
• W1844276506 countsByYear W18442765062015 @default.
• W1844276506 countsByYear W18442765062016 @default.
• W1844276506 countsByYear W18442765062017 @default.
• W1844276506 countsByYear W18442765062018 @default.
• W1844276506 countsByYear W18442765062019 @default.
• W1844276506 countsByYear W18442765062020 @default.
• W1844276506 countsByYear W18442765062021 @default.
• W1844276506 countsByYear W18442765062022 @default.
• W1844276506 countsByYear W18442765062023 @default.
• W1844276506 crossrefType "journal-article" @default.
• W1844276506 hasAuthorship W1844276506A5009477531 @default.
• W1844276506 hasAuthorship W1844276506A5013510546 @default.
• W1844276506 hasAuthorship W1844276506A5022837013 @default.
• W1844276506 hasAuthorship W1844276506A5085492328 @default.
• W1844276506 hasBestOaLocation W18442765061 @default.
• W1844276506 hasConcept C125705527 @default.
• W1844276506 hasConcept C147483822 @default.
• W1844276506 hasConcept C185592680 @default.
• W1844276506 hasConcept C203014093 @default.
• W1844276506 hasConcept C207936829 @default.
• W1844276506 hasConcept C2776090121 @default.
• W1844276506 hasConcept C2778170410 @default.
• W1844276506 hasConcept C2778814158 @default.
• W1844276506 hasConcept C2778934503 @default.
• W1844276506 hasConcept C83464605 @default.
• W1844276506 hasConcept C86803240 @default.
• W1844276506 hasConcept C8891405 @default.
• W1844276506 hasConcept C95444343 @default.
• W1844276506 hasConceptScore W1844276506C125705527 @default.
• W1844276506 hasConceptScore W1844276506C147483822 @default.
• W1844276506 hasConceptScore W1844276506C185592680 @default.
• W1844276506 hasConceptScore W1844276506C203014093 @default.
• W1844276506 hasConceptScore W1844276506C207936829 @default.
• W1844276506 hasConceptScore W1844276506C2776090121 @default.

• next