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- W1844294423 abstract "Erectile dysfunction (ED) represents one of the most common long-term side effects in patients with clinically localized prostate cancer (PCa) undergoing nerve-sparing radical prostatectomy (RP).To analyze the role of penile rehabilitation in the recovery of erectile function (EF) after nerve-sparing RP.Penile rehabilitation is defined as the use of any intervention or combination with the goal not only to achieve erections sufficient for satisfactory sexual intercourses, but also to return EF to preoperative levels. The concept of rehabilitation is based on the implementation of protocols aimed at improving oxygenation, preserving endothelial structure, and preventing smooth muscle structural alterations. Nowadays, the most commonly adopted approaches for penile rehabilitation after nerve-sparing RP are represented by the administration of phosphodiesterase type-5 inhibitors (PDE5-Is), intracorporeal injection therapy, vacuum erection devices (VED), and the combination of these therapies. Several basic science studies support the rational for the adoption of penile rehabilitation protocols. Particularly, rehabilitation, set as early as possible, seems to be better than leaving the erectile tissues unassisted. On the other hand, results from solid prospective randomized trials finally assessing the long-term beneficial effects of PDE5-Is, intracavernosal injections, or VED on EF recovery after surgery are still lacking.Although preclinical evidences support the rationale for penile rehabilitation after nerve-sparing RP, clinical studies reported conflicting results regarding its efficacy on long-term EF recovery. Nowadays, which is the optimal rehabilitation program still represents a matter of debate." @default.
- W1844294423 created "2016-06-24" @default.
- W1844294423 creator A5023266580 @default.
- W1844294423 creator A5031550729 @default.
- W1844294423 creator A5058036624 @default.
- W1844294423 creator A5059157811 @default.
- W1844294423 creator A5061623935 @default.
- W1844294423 creator A5064914239 @default.
- W1844294423 creator A5071652086 @default.
- W1844294423 creator A5078919686 @default.
- W1844294423 creator A5079401169 @default.
- W1844294423 date "2015-04-01" @default.
- W1844294423 modified "2023-09-25" @default.
- W1844294423 title "Penile rehabilitation after radical prostatectomy: does it work?" @default.
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