FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844332144> ?p ?o ?g. }

• W1844332144 endingPage "42129" @default.
• W1844332144 startingPage "42118" @default.
• W1844332144 abstract "// Chun-Hua Wang 1, 2, * , Min Li 1, 2, * , Li-Li Liu 1, 2 , Ruo-Yao Zhou 3 , Jia Fu 1, 2 , Chris Zhiyi Zhang 1, 2 , Jing-Ping Yun 1, 2 1 Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China 2 Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China 3 Okemos High School, Okemos MI 48864, USA * These authors have contributed equally to this work Correspondence to: Jing-Ping Yun, e-mail: yunjp@sysucc.org.cn Keywords: LRG1, prognosis, immunohistochemistry, hepatocellular carcinoma Received: March 27, 2015      Accepted: October 09, 2015      Published: October 19, 2015 ABSTRACT Leucine-rich-alpha-2-glycoprotein1 (LRG1) is a novel oncogene-associated protein which has been clarified vital to the progression of human cancers, but its role in hepatocellular carcinoma (HCC) remains unclear. Here, we showed that the expression of LRG1 was noticeably increased in HCC tissues, compared to the nontumorous tissues. High LRG1 expression was significantly associated with tumor size ( P = 0.004), tumor differentiation ( P = 0.010), TNM stage ( P < 0.001) and vascular invasion ( P = 0.019). Kaplan-Meier analysis showed that LRG1 expression was closely correlated to overall survival and disease-free survival in a training cohort of 474 patients with HCC. The correlation was further validated in an independent cohort of 303 HCC patients. The prognostic implication of LRG1 was confirmed by stratified survival analyses. Multivariate Cox regression model indicated LRG1 as an independent poor prognostic indicator for overall survival (Hazard ratio = 1.582, 95% confident interval: 1.345–1.862, P < 0.001) and disease-free survival (Hazard ratio = 1.280, 95% confident interval: 1.037–1.581, P = 0.022) in HCC. In vitro data showed that LRG1 markedly promoted cell migration but has no effect on cell proliferation. Collectively, our data show that LRG1 is markedly up-regulated and serves as an independent factor of poor outcomes in HCC. Our study therefore provides a promising biomarker for prognostic prediction in clinical management of HCC." @default.
• W1844332144 created "2016-06-24" @default.
• W1844332144 creator A5007049678 @default.
• W1844332144 creator A5032937513 @default.
• W1844332144 creator A5046589394 @default.
• W1844332144 creator A5055880436 @default.
• W1844332144 creator A5067173088 @default.
• W1844332144 creator A5072969391 @default.
• W1844332144 creator A5074054418 @default.
• W1844332144 date "2015-10-19" @default.
• W1844332144 modified "2023-10-05" @default.
• W1844332144 title "LRG1 expression indicates unfavorable clinical outcome in hepatocellular carcinoma" @default.
• W1844332144 cites W1498100050 @default.
• W1844332144 cites W1544285763 @default.
• W1844332144 cites W1971119095 @default.
• W1844332144 cites W1975487068 @default.
• W1844332144 cites W1976444087 @default.
• W1844332144 cites W1981045929 @default.
• W1844332144 cites W1984375778 @default.
• W1844332144 cites W1993899459 @default.
• W1844332144 cites W2021466957 @default.
• W1844332144 cites W2025310342 @default.
• W1844332144 cites W2030905683 @default.
• W1844332144 cites W2056035608 @default.
• W1844332144 cites W2062330494 @default.
• W1844332144 cites W2069219703 @default.
• W1844332144 cites W2076365126 @default.
• W1844332144 cites W2081214164 @default.
• W1844332144 cites W2081248563 @default.
• W1844332144 cites W2086607694 @default.
• W1844332144 cites W2118225297 @default.
• W1844332144 cites W2131193868 @default.
• W1844332144 cites W2131400752 @default.
• W1844332144 cites W2141736769 @default.
• W1844332144 cites W2152915643 @default.
• W1844332144 cites W2157161256 @default.
• W1844332144 cites W2163101954 @default.
• W1844332144 cites W2164443190 @default.
• W1844332144 cites W2329997650 @default.
• W1844332144 cites W2917837889 @default.
• W1844332144 cites W2992845875 @default.
• W1844332144 cites W4243246706 @default.
• W1844332144 cites W4312694002 @default.
• W1844332144 doi "https://doi.org/10.18632/oncotarget.5967" @default.
• W1844332144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4747214" @default.
• W1844332144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26517349" @default.
• W1844332144 hasPublicationYear "2015" @default.
• W1844332144 type Work @default.
• W1844332144 sameAs 1844332144 @default.
• W1844332144 citedByCount "34" @default.
• W1844332144 countsByYear W18443321442017 @default.
• W1844332144 countsByYear W18443321442018 @default.
• W1844332144 countsByYear W18443321442019 @default.
• W1844332144 countsByYear W18443321442020 @default.
• W1844332144 countsByYear W18443321442021 @default.
• W1844332144 countsByYear W18443321442022 @default.
• W1844332144 countsByYear W18443321442023 @default.
• W1844332144 crossrefType "journal-article" @default.
• W1844332144 hasAuthorship W1844332144A5007049678 @default.
• W1844332144 hasAuthorship W1844332144A5032937513 @default.
• W1844332144 hasAuthorship W1844332144A5046589394 @default.
• W1844332144 hasAuthorship W1844332144A5055880436 @default.
• W1844332144 hasAuthorship W1844332144A5067173088 @default.
• W1844332144 hasAuthorship W1844332144A5072969391 @default.
• W1844332144 hasAuthorship W1844332144A5074054418 @default.
• W1844332144 hasBestOaLocation W18443321441 @default.
• W1844332144 hasConcept C121608353 @default.
• W1844332144 hasConcept C126322002 @default.
• W1844332144 hasConcept C143998085 @default.
• W1844332144 hasConcept C146357865 @default.
• W1844332144 hasConcept C151730666 @default.
• W1844332144 hasConcept C204232928 @default.
• W1844332144 hasConcept C2778019345 @default.
• W1844332144 hasConcept C2781018059 @default.
• W1844332144 hasConcept C29537977 @default.
• W1844332144 hasConcept C71924100 @default.
• W1844332144 hasConcept C72563966 @default.
• W1844332144 hasConcept C86803240 @default.
• W1844332144 hasConceptScore W1844332144C121608353 @default.
• W1844332144 hasConceptScore W1844332144C126322002 @default.
• W1844332144 hasConceptScore W1844332144C143998085 @default.
• W1844332144 hasConceptScore W1844332144C146357865 @default.
• W1844332144 hasConceptScore W1844332144C151730666 @default.
• W1844332144 hasConceptScore W1844332144C204232928 @default.
• W1844332144 hasConceptScore W1844332144C2778019345 @default.
• W1844332144 hasConceptScore W1844332144C2781018059 @default.
• W1844332144 hasConceptScore W1844332144C29537977 @default.
• W1844332144 hasConceptScore W1844332144C71924100 @default.
• W1844332144 hasConceptScore W1844332144C72563966 @default.
• W1844332144 hasConceptScore W1844332144C86803240 @default.
• W1844332144 hasIssue "39" @default.
• W1844332144 hasLocation W18443321441 @default.
• W1844332144 hasLocation W18443321442 @default.
• W1844332144 hasLocation W18443321443 @default.
• W1844332144 hasLocation W18443321444 @default.
• W1844332144 hasOpenAccess W1844332144 @default.
• W1844332144 hasPrimaryLocation W18443321441 @default.
• W1844332144 hasRelatedWork W2138198379 @default.

• next