FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1844334486> ?p ?o ?g. }

• W1844334486 endingPage "2037" @default.
• W1844334486 startingPage "2031" @default.
• W1844334486 abstract "Abstract Inherited anemias with ineffective erythropoiesis, such as β-thalassemia, manifest inappropriately low hepcidin production and consequent excessive absorption of dietary iron, leading to iron overload. Erythroferrone (ERFE) is an erythroid regulator of hepcidin synthesis and iron homeostasis. Erfe expression was highly increased in the marrow and spleen of HbbTh3/+ mice (Th3/+), a mouse model of thalassemia intermedia. Ablation of Erfe in Th3/+ mice restored normal levels of circulating hepcidin at 6 weeks of age, suggesting ERFE could be a factor suppressing hepcidin production in β-thalassemia. We examined the expression of Erfe and the consequences of its ablation in thalassemic mice from 3 to 12 weeks of age. The loss of ERFE in thalassemic mice led to full restoration of hepcidin mRNA expression at 3 and 6 weeks of age, and significant reduction in liver and spleen iron content at 6 and 12 weeks of age. Ablation of Erfe slightly ameliorated ineffective erythropoiesis, as indicated by reduced spleen index, red cell distribution width, and mean corpuscular volume, but did not improve the anemia. Thus, ERFE mediates hepcidin suppression and contributes to iron overload in a mouse model of β-thalassemia." @default.
• W1844334486 created "2016-06-24" @default.
• W1844334486 creator A5034090271 @default.
• W1844334486 creator A5035815172 @default.
• W1844334486 creator A5036220506 @default.
• W1844334486 creator A5046694314 @default.
• W1844334486 creator A5052440137 @default.
• W1844334486 creator A5065597128 @default.
• W1844334486 creator A5072413981 @default.
• W1844334486 creator A5087563095 @default.
• W1844334486 date "2015-10-22" @default.
• W1844334486 modified "2023-10-16" @default.
• W1844334486 title "Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia" @default.
• W1844334486 cites W1604244149 @default.
• W1844334486 cites W1969230979 @default.
• W1844334486 cites W1975590431 @default.
• W1844334486 cites W1980042430 @default.
• W1844334486 cites W1983048915 @default.
• W1844334486 cites W1983551732 @default.
• W1844334486 cites W1992083687 @default.
• W1844334486 cites W1997846723 @default.
• W1844334486 cites W2001570896 @default.
• W1844334486 cites W2006046265 @default.
• W1844334486 cites W2020932850 @default.
• W1844334486 cites W2023209642 @default.
• W1844334486 cites W2051875442 @default.
• W1844334486 cites W2052473168 @default.
• W1844334486 cites W2066783828 @default.
• W1844334486 cites W2083838269 @default.
• W1844334486 cites W2083855314 @default.
• W1844334486 cites W2086284653 @default.
• W1844334486 cites W2087535882 @default.
• W1844334486 cites W2088903681 @default.
• W1844334486 cites W2091952666 @default.
• W1844334486 cites W2094155951 @default.
• W1844334486 cites W2095400049 @default.
• W1844334486 cites W2100184006 @default.
• W1844334486 cites W2107423980 @default.
• W1844334486 cites W2107894900 @default.
• W1844334486 cites W2115311848 @default.
• W1844334486 cites W2125118264 @default.
• W1844334486 cites W2163438420 @default.
• W1844334486 cites W2589417141 @default.
• W1844334486 cites W4234693960 @default.
• W1844334486 doi "https://doi.org/10.1182/blood-2015-07-658419" @default.
• W1844334486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4616236" @default.
• W1844334486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26276665" @default.
• W1844334486 hasPublicationYear "2015" @default.
• W1844334486 type Work @default.
• W1844334486 sameAs 1844334486 @default.
• W1844334486 citedByCount "224" @default.
• W1844334486 countsByYear W18443344862015 @default.
• W1844334486 countsByYear W18443344862016 @default.
• W1844334486 countsByYear W18443344862017 @default.
• W1844334486 countsByYear W18443344862018 @default.
• W1844334486 countsByYear W18443344862019 @default.
• W1844334486 countsByYear W18443344862020 @default.
• W1844334486 countsByYear W18443344862021 @default.
• W1844334486 countsByYear W18443344862022 @default.
• W1844334486 countsByYear W18443344862023 @default.
• W1844334486 crossrefType "journal-article" @default.
• W1844334486 hasAuthorship W1844334486A5034090271 @default.
• W1844334486 hasAuthorship W1844334486A5035815172 @default.
• W1844334486 hasAuthorship W1844334486A5036220506 @default.
• W1844334486 hasAuthorship W1844334486A5046694314 @default.
• W1844334486 hasAuthorship W1844334486A5052440137 @default.
• W1844334486 hasAuthorship W1844334486A5065597128 @default.
• W1844334486 hasAuthorship W1844334486A5072413981 @default.
• W1844334486 hasAuthorship W1844334486A5087563095 @default.
• W1844334486 hasBestOaLocation W18443344861 @default.
• W1844334486 hasConcept C126322002 @default.
• W1844334486 hasConcept C134018914 @default.
• W1844334486 hasConcept C2776768029 @default.
• W1844334486 hasConcept C2777799968 @default.
• W1844334486 hasConcept C2777940137 @default.
• W1844334486 hasConcept C2778248108 @default.
• W1844334486 hasConcept C2779703530 @default.
• W1844334486 hasConcept C2780844101 @default.
• W1844334486 hasConcept C2780931953 @default.
• W1844334486 hasConcept C71924100 @default.
• W1844334486 hasConcept C86803240 @default.
• W1844334486 hasConceptScore W1844334486C126322002 @default.
• W1844334486 hasConceptScore W1844334486C134018914 @default.
• W1844334486 hasConceptScore W1844334486C2776768029 @default.
• W1844334486 hasConceptScore W1844334486C2777799968 @default.
• W1844334486 hasConceptScore W1844334486C2777940137 @default.
• W1844334486 hasConceptScore W1844334486C2778248108 @default.
• W1844334486 hasConceptScore W1844334486C2779703530 @default.
• W1844334486 hasConceptScore W1844334486C2780844101 @default.
• W1844334486 hasConceptScore W1844334486C2780931953 @default.
• W1844334486 hasConceptScore W1844334486C71924100 @default.
• W1844334486 hasConceptScore W1844334486C86803240 @default.
• W1844334486 hasIssue "17" @default.
• W1844334486 hasLocation W18443344861 @default.
• W1844334486 hasLocation W18443344862 @default.
• W1844334486 hasLocation W18443344863 @default.
• W1844334486 hasOpenAccess W1844334486 @default.
• W1844334486 hasPrimaryLocation W18443344861 @default.

• next