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• W1844385719 abstract "A116 There has been no evidence showing that IL-1β gene polymorphisms (-511 and -31) are associated with small cell lung cancer (SCLC). Therefore, IL-1β gene polymorphisms were studied for their association with NSCLC and SCLC in Japanese. Our study involved 444 individuals of Japanese origin. The subjects were newly diagnosed lung cancer patients at Tohoku University Hospital and the Miyagi Cancer Center Research Institute in Miyagi prefecture between 2001 and 2004. Both patients with lung cancer and controls were recruited because they met our enrollment criteria, as follows; (1) newly diagnosed as patients with lung cancer by pathohistological diagnosis between 2001 and 2004, (2) patients without IL-1 beta related disease including gastric cancer, hepatocellular carcinoma, breast cancer, collagen diseases, and gastroduodenal ulcer, (3) age more than 50, (4) Japanese, and (5) informed consent regarding attendance for this study could be obtained. A Ninety-five of 220 patients had adenocarcinomas, 92 patients had squamous cell carcinoma, and 33 patients had small cell carcinoma. The 224 controls were recruited from Miyagi health screening 2001-2002. DNA was extracted from peripheral blood. IL-1β genotyping was carried out. The genotype distributions and frequencies of alleles were compared between lung cancer cases and control groups. The C allele at -511 SNP was of particularly higher risk for lung cancer with a relative risk of 1.9 (95% confidence interval = 1.3-2.7) . In this study, IL-1β -31 and -511 loci did not have complete linkage disequilibrium (D9=0.77, r2=0.58). There was no difference in the IL-1β -31 and genotyped frequency of IL-1β between lung cancer patients and controls.Next, the genotypes of IL-1β gene polymorphisms at loci -511 C-T were further analyzed in NSCLC cases, SCLC cases and healthy controls. The distribution of IL-1β -511 genotypes with SCLC or NSCLC cases was similar to lung cancer cases. The C allele at -511 SNP was also at particularly higher risk for cancer with a relative risk of 3.0 (95% CI = 1.1- 9.0) in SCLC cases and 1.9 (95% CI = 1.3 - 2.7) in NSCLC cases, but there were no differences in the homogeneous types of -31 SNP and the genotyped frequency of IL-1β between SCLC cases and controls. Herein, the IL-1β -511 C allele was demonstrated to be associated with onset risks in not only NSCLC but SCLC in Japanese, but the positive relationship between the IL-1β -31 SNP and NSCLC onset risk in this study is not consistent with previous reports from Central and Eastern Europe. The onset of chronic obstructive pulmonary disease (COPD) was reported to be associated with the IL-1β -511 C allele SNP in Japanese. Furthermore, an increased risk of lung cancer onset in Japanese patients with COPD was reported. This suggests that lung cancer risk may be increased in Japanese patients with chronic pulmonary inflammation regulated by IL-1β and may not be related with the IL-1β -31 T allele but with the IL-1" @default.
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• W1844385719 date "2006-10-01" @default.
• W1844385719 modified "2023-09-28" @default.
• W1844385719 title "Interleukin-1β gene polymorphisms associated with risk of lung cancer in Japanese" @default.
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